HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Personal Folders Download to citation manager Author home page(s): Gregory A Thomas Larry W Stephenson Permission Requests Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Thomas, G. A. Articles by Stephenson, L. W. Search for Related Content PubMed PubMed Citation Articles by Thomas, G. A. Articles by Stephenson, L. W.

Ann Thorac Surg 2001;71:1736-1737
© 2001 The Society of Thoracic Surgeons

---

Update

Update 2001: Skeletal muscle ventricles: left ventricular apex to aorta configuration

^a Division of Cardiothoracic Surgery, Wayne State University School of Medicine, Detroit, Michigan, USA

^* Address reprint requests to Dr Stephenson, Cardiothoracic Surgery, Suite 2102, Harper Professional Building, 3990 John R St, Detroit, MI 48201

As Originally Published in 1993: Skeletal Muscle Ventricles: Left Ventricular Apex to Aorta Configuration

Huiping Lu, MD, Robert Fietsam, Jr, MD, Robert L. Hammond, MD, Hidehiro Nakajima, MD, Frank W. Mocek, MD, Gregory A. Thomas, MD, Renato Ruggiero, MD, Hisako Nakajima, MD, Michael Colson, MS, and Larry W. Stephenson, MD

Division of Cardiothoracic Surgery, Department of Surgery, Wayne State University, Detroit, Michigan, and Medtronics, Inc, Minneapolis, Minnesota

Abstract—Skeletal muscle ventricles (SMVs) were constructed from the latissimus dorsi muscle in 6 dogs. After 3 weeks of vascular delay followed by 6 weeks of 2-Hz continuous electrical conditioning, a valved conduit was placed between the left ventricular apex and the SMV and a second valved conduit, between the SMV and the aorta. The SMV was stimulated to contract during diastole at a 1:2 ratio with the heart. The SMV pumped 47% of the systemic blood flow initially (0.73 ± 0.23 versus 1.54 ± 0.42 L/min) and 40% after 3 hours. Skeletal muscle ventricle stimulation resulted in a 58% increase in mean diastolic pressure initially (52 ± 9 to 82 ± 11 mm Hg; p < 0.05) and a 73% increase (45 ± 7 to 78 ± 8 mm Hg) after 3 hours of continuous pumping. This was associated with a 68% increase in the endocardial viability ratio initially and a 63% increase at 3 hours. The systolic tension-time index decreased by 26% initially and 25% at 3 hours. This study indicates that the SMV configuration of left ventricular apex to aorta may be particularly suitable for left ventricular assist.