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Carlos Blanche
Ivan Aleksic
Johanna J.M. Takkenberg
Alfredo Trento
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Ann Thorac Surg 1995;60:1406-1409
© 1995 The Society of Thoracic Surgeons

Articles

Heart transplantation for chagas' cardiomyopathy

MD Carlos Blanche*, MD Ivan Aleksic, MD Johanna J.M. Takkenberg, MD Lawrence S.C. Czer, MD Michael C. Fishbein, MD Alfredo Trento

Department of Cardiothoracic Surgery, Cedars-Sinai Medical Center, Los Angeles, California, USA

Accepted for publication April 28, 1995.

* Address reprint requests to Dr Blanche, Heart Transplant Program, Cedars-Sinai Medical Center, 8700 Beverly Blvd, Suite 6215, Los Angeles, CA 90048.

We present 2 patients who underwent orthotopic heart transplantation for end-stage Chagas' cardiomyopathy. Despite immunosuppressive therapy, postoperative prophylaxis with nifurtimox appeared to prevent Trypanosoma cruzi reactivation. Neither patient has shown signs of Chagas' myocarditis, and both are clinically well 12 and 72 months after transplantation. The successful outcome of our patients suggests that heart transplantation is a reasonable therapeutic option in patients with end-stage Chagas' cardiomyopathy.




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