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William H. Frist
James R. Stewart
Daryl P. Pearlstein
Steven P. Key
Walter H. Merrill
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Ann Thorac Surg 1995;60:268-271
© 1995 The Society of Thoracic Surgeons

Articles

MRI complements standard assessment of right ventricular function after lung transplantation

MD William H. Frist*, PhD Christine H. Lorenz, MD Eloisa S. Walker, MD James E. Loyd, MD James R. Stewart, MD Thomas P. Graham, Jr, BA Daryl P. Pearlstein, MD Steven P. Key, MD Walter H. Merrill

Departments of Cardiac and Thoracic Surgery, Radiology and Radiological Sciences, Divisions of Pulmonary and Critical Care Medicine, Pediatric Cardiology, and the Vanderbilt Transplant Center, Vanderbilt University Medical Center, Nashville, Tennessee, USA

* Address reprint requests to Dr Frist, c/o Daryl P. Pearlstein, 344 Village at Vanderbilt, Nashville, TN 37212.

Background.: Changes in right ventricular mass and ejection fraction after single-lung transplantation for pulmonary hypertension are poorly understood.

Methods.: To complement functional data provided by echocardiography, radionuclide ventriculography, and right heart catheterization, magnetic resonance imaging was used to assess right ventricular function in 5 single-lung transplant recipients with preoperative pulmonary hypertension and right ventricular dysfunction (right ventricular ejection fraction, 0.21 ± 0.09). The right and left ventricular mass, ejection fraction, and mass ratio (left ventricular mass/right ventricular mass) were calculated from the magnetic resonance images.

Results.: The mean pulmonary artery pressure fell from 72 ± 18 to 21 ± 8 mm Hg after transplantation. At 3 months after transplantation both the left ventricular and right ventricular ejection fractions approached normal values, as shown by both radionuclide ventriculography and magnetic resonance imaging, but the right ventricular mass remained abnormally high with slightly low mass ratios. By 1 year both the left ventricular and right ventricular masses had regressed to normal with near-normal mass ratios.

Conclusions.: Right ventricular performance returns to nearly normal early after transplantation, but the right ventricular mass regresses over a more prolonged time. Cine magnetic resonance imaging provides a noninvasive means of assessing changes in right ventricular function and mass after lung transplantation.




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