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Ann Thorac Surg 1995;59:1015-1017
© 1995 The Society of Thoracic Surgeons

Articles

Liposomal amphotericin B for postoperative Aspergillus fumigatus endocarditis

MD Martin C.K. Hosking*, MD Noni E. MacDonald, MB, BS Garry Cornel

Divisions of Cardiology, Infectious Diseases and Cardiovascular Surgery, Childrens Hospital of Eastern Ontario, Ottawa, Ontario, Canada

Accepted for publication August 19, 1994.

* Address reprint requests to Dr Hosking, Division of Cardiology, Childrens Hospital of Eastern Ontario, 401 Smyth Rd, Ottawa, Ont Canada K1H 8L1.

A 10-month-old infant girl presented with Aspergillus fumigatus endocarditis localized to a Gore-Tex patch used as part of the repair for double-outlet right ventricle. A new liposomal preparation of amphotericin B combined with surgical vegectomy resulted in a successful outcome with no evidence of disease recurrence at 15 months' follow-up. Echocardiography provided an optimal modality for ongoing evaluation of therapeutic outcome.




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