Ann Thorac Surg 1995;59:759-761
© 1995 The Society of Thoracic Surgeons
Articles
Fungal pulmonary abscess in an adult secondary to hyperimmunoglobulin E (Job's) syndrome
MD R. Alan Hall,
MD Kevin E. Salhany,
MD Elise Lebel,
MD Joseph E. Bavaria,
MD Larry R. Kaiser*
Department of Surgery, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania, USA
Accepted for publication July 14, 1994.
* Address reprint requests to Dr Kaiser, Hospital of the University of Pennsylvania, 34th and Spruce Sts, 4 Silverstein, Philadelphia, PA 19104.
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Abstract
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Job's syndrome is characterized by recurring bacterial infections of the skin and sinopulmonary tract. Laboratory evaluation reveals consistent elevation of circulating immunoglobulin E levels. The syndrome has been reported as a rare cause of bacterial pulmonary abscess and pneumatocele formation in childhood; here we present a case of cavitating fungal abscess in an adult with Job's syndrome.
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References
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- Davis SD, Schaller J, Wedgwood RJ. Job's syndrome: recurrent "cold" staphylococcal abscesses Lancet 1966;1:1013-1015.[Medline]
- Buckley RH, Wray BB, Belmaker EZ. Extreme hyperimmunoglobulinemia E and undue susceptibility to infection Pediatrics 1972;49:59-70.[Abstract/Free Full Text]
- Clark RA, Root RK, Kimball HR, Kirkpatrick CH. Defective neutrophil chemotaxis and cellular immunity in a child with recurrent infections Ann Intern Med 1973;78:515-519.[Medline]
- Gallin JI. Disorders of phagocyte chemotaxis Ann Intern Med 1980;92:520-538.[Medline]
- Gallin JI. Abnormal phagocyte chemotaxis: pathophysiology, clinical manifestations and management of patients Rev Inf Dis 1981;3:1196-1220.[Medline]
- Hill HR, Quie PG. Raised serum IgE levels and defective neutrophil chemotaxis in three children with eczema and recurrent bacterial infections Lancet 1974;1:183-187.[Medline]
- Hill HR, Quie PG, Pabst HF, et al. Defect in neutrophil granulocyte chemotaxis in Job's syndrome of recurrent "cold" staphylococcal abscesses Lancet 1974;2:617-619.[Medline]
- Donabedian H, Gallin JI. The hyperimmunoglobulin E recurrent-infection (Job's) syndrome: a review of the NIH experience and the literature Medicine 1983;62:195-208.[Medline]
- Shamberger RC, Wohl ME, Perez-Atayde A, Hendren WH. Pneumatocele complicating hyperimmunoglobulin E syndrome (Job's syndrome) Ann Thorac Surg 1992;54:1206-1208.[Abstract/Free Full Text]
- Vercelli D, Jabara HH, Cunningham-Rundles C, et al. Regulation of immunoglobulin (Ig)E synthesis in the hyper-IgE syndrome J Clin Invest 1990;85:1666-1671.[Medline]
- Donabedian H, Gallin JI. Mononuclear cells from the patients with the hyperimmunoglobulin E-recurrent infection syndrome produce an inhibitor of leukocyte chemotaxis J Clin Invest 1982;69:1155-1163.[Medline]
- Nielsen H, Valerius NH, Schaffalitzky OB. Selective defect of phagocyte responsiveness to N-f-Met-Leu-Phe in a familial syndrome of recurrent cold abscesses J Infect Dis 1986;153:1184-1186.[Free Full Text]
- Lindenbaum C, Chatwani A, Dyer R. Hyperimmunoglobulinemia E and pregnancy: a case report Am J Obstet Gynecol 1987;157:1273-1274.[Medline]
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