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Ann Thorac Surg 1995;59:759-761
© 1995 The Society of Thoracic Surgeons


Articles

Fungal pulmonary abscess in an adult secondary to hyperimmunoglobulin E (Job's) syndrome

MD R. Alan Hall, MD Kevin E. Salhany, MD Elise Lebel, MD Joseph E. Bavaria, MD Larry R. Kaiser*

Department of Surgery, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania, USA

Accepted for publication July 14, 1994.

* Address reprint requests to Dr Kaiser, Hospital of the University of Pennsylvania, 34th and Spruce Sts, 4 Silverstein, Philadelphia, PA 19104.


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Job's syndrome is characterized by recurring bacterial infections of the skin and sinopulmonary tract. Laboratory evaluation reveals consistent elevation of circulating immunoglobulin E levels. The syndrome has been reported as a rare cause of bacterial pulmonary abscess and pneumatocele formation in childhood; here we present a case of cavitating fungal abscess in an adult with Job's syndrome.


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  1. Davis SD, Schaller J, Wedgwood RJ. Job's syndrome: recurrent "cold" staphylococcal abscesses Lancet 1966;1:1013-1015.[Medline]
  2. Buckley RH, Wray BB, Belmaker EZ. Extreme hyperimmunoglobulinemia E and undue susceptibility to infection Pediatrics 1972;49:59-70.[Abstract/Free Full Text]
  3. Clark RA, Root RK, Kimball HR, Kirkpatrick CH. Defective neutrophil chemotaxis and cellular immunity in a child with recurrent infections Ann Intern Med 1973;78:515-519.[Medline]
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  8. Donabedian H, Gallin JI. The hyperimmunoglobulin E recurrent-infection (Job's) syndrome: a review of the NIH experience and the literature Medicine 1983;62:195-208.[Medline]
  9. Shamberger RC, Wohl ME, Perez-Atayde A, Hendren WH. Pneumatocele complicating hyperimmunoglobulin E syndrome (Job's syndrome) Ann Thorac Surg 1992;54:1206-1208.[Abstract/Free Full Text]
  10. Vercelli D, Jabara HH, Cunningham-Rundles C, et al. Regulation of immunoglobulin (Ig)E synthesis in the hyper-IgE syndrome J Clin Invest 1990;85:1666-1671.[Medline]
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  12. Nielsen H, Valerius NH, Schaffalitzky OB. Selective defect of phagocyte responsiveness to N-f-Met-Leu-Phe in a familial syndrome of recurrent cold abscesses J Infect Dis 1986;153:1184-1186.[Free Full Text]
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This Article
Right arrow Abstract Freely available
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Right arrow Articles by Hall, R. A.
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PubMed
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Right arrow Articles by Hall, R. A.
Right arrow Articles by Kaiser, L. R.