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Ann Thorac Surg 1993;55:276-282
© 1993 The Society of Thoracic Surgeons

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Articles

Univentricular and biventricular thoratec VAD support as a bridge to transplantation

Department of Cardiovascular Surgery, California Pacific Medical Center, San Francisco, California USA

^_* Address reprint requests to Dr Farrar, Department of Cardiovascular Surgery, California Pacific Medical Center, PO Box 7999, San Francisco, CA 94120.

	Abstract

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As of October 1991, the Thoratec ventricular assist device (VAD) system has been used in 154 transplant candidates who were in imminent risk of dying before donor heart procurement at 39 medical centers in 10 countries. The VAD system consists of a prosthetic ventricle with a 65-mL pumping chamber made from Thoratec's BPS-215M polyurethane, cannulas for atrial or ventricular inflow and arterial outflow connections, and a pneumatic drive console. The devices can be used for partial or complete support of the pulmonary, systemic, or both circulations. In all patients (average age, 42 years; range, 11 to 64 years), the pumps were placed in a paracorporeal position on the anterior abdominal wall and connected to the heart and great vessels by cannulas crossing the chest wall. Biventricular support was used in 120 patients (78%) and isolated left VADs were used in 34. Average flow rate was 5.0 ± 0.9 L/min for the left VAD and 4.3 ± 0.8 L/min for the right VAD. The most frequent complications were bleeding (42% incidence, 7% mortality) and infection (36% incidence, 8% mortality). Ninety-eight patients (65%) recovered sufficiently to undergo heart transplantation after 8 hours to 226 days of support (average, 17.5 days), and 3 are waiting on VADs for transplantation. Eighty-two patients who received transplants have been discharged. This is an 84% early posttransplantation survival and a 54% overall survival. The actuarial survival 1 year after transplantation is 82%, comparable with that of conventional heart transplantation. We conclude that these heterotopic prosthetic devices provide an effective method of maintaining blood flow to vital organs until a donor heart can be procured.

	Footnotes

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Presented at the Circulatory Support 1991 Symposium of The Society of Thoracic Surgeons, San Francisco, CA, Nov 16–17, 1991.

¹ Dr Farrar is a part-time employee of Thoratec Laboratories.

	References

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1. Hill JD. Bridging to cardiac transplantation Ann Thorac Surg 1989;47:167-171.[Abstract/Free Full Text]
2. Pennington DG, Swartz MT. Assisted circulation and the mechanical heartIn: Braunwald E, editor. Heart disease: a textbook of cardiovascular medicine. Philadelphia: Saunders; 1991. pp. 535-550.
3. Farrar DJ, Hill JD, Gray Jr LA, et al. Heterotopic prosthetic ventricles as a bridge to cardiac transplantation: a multicenter study in 29 patients N Engl J Med 1988;318:333-340.[Medline]
4. Farrar DJ, Lawson JH, Litwak P, Cederwall G. Thoratec VAD system as a bridge to heart transplantation J Heart Transplant 1990;9:415-423.[Medline]
5. Farrar DJ, Compton PG, Lawson JH, et al. In vivo evaluations of a new thromboresistant polyurethane for artificial heart blood pumps J Thorac Cardiovasc Surg 1988;95:191-200.[Abstract]
6. Farrar DJ, Litwak P, Lawson JH, Hershon JJ, Hill JD. Control modes of a clinical ventricular assist device IEEE Eng Med Biol 1986;5:19-25.[Medline]
7. Ganzel BL, Gray Jr LA, Slater AD, Mavroudis C. Surgical techniques for the implantation of heterotopic prosthetic ventricles Ann Thorac Surg 1989;47:113-120.[Abstract/Free Full Text]
8. Kriett JM, Kaye MP. The Registry of the International Society for Heart and Lung Transplantation: eighth official report—1991 J Heart Transplant 1991;10:491-498.
9. Pennington DG, Reedy JE, Swartz MT, et al. Univentricular vs biventricular assist device support J Heart Transplant 1991;10:258-263.
10. Pennington DG, McBride LR, Swartz MT, et al. Use of the Pierce-Donachy ventricular assist device in patients with cardiogenic shock after cardiac operations Ann Thorac Surg 1989;47:130-135.[Abstract/Free Full Text]
11. Holman WL, Bourge RC, Kirklin JK. Circulatory support for seventy days with resolution of acute heart failure J Thorac Cardiovasc Surg 1991;102:932-934.[Medline]
12. Gray LA, Ganzel BL, Mavroudis C, Slater AD. The Pierce-Donachy ventricular assist device as a bridge to cardiac transplantation Ann Thorac Surg 1989;48:222-227.[Abstract/Free Full Text]
13. Reedy J, Swartz M, Lohmann D, et al. The importance of patient mobility with ventricular assist device (VAD) support ASAIO J 1992;38:M151-M153.[Medline]
14. Elsesser CC, Smith BJ. Implementing a ventricular assist device program: a partnership between nursing and clinical engineering. Focus on Critical Care AACN 1991;18:14-22.
15. Ley SJ. The Thoratec ventricular assist device: nursing guidelines AACN Clinical Issues in Critical Care Nursing 1991;2:529-544.[Medline]

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