Ann Thorac Surg 1991;52:886-895
© 1991 The Society of Thoracic Surgeons
Articles
Cardiac tumors: Clinical experience and surgical results in 74 patients
Albert Miralles, MD,
Luis Bracamonte, MD,
Halim Soncul, MD,
Roberto Diaz del Castillo, MD,
Rama Akhtar, MD,
Valería Bors, MD,
Alain Pavie, MD,
Iradj Gandjbackhch, MD,
Christian Cabrol, MD*
Department of Thoracic and Cardiovascular Surgery, Hopital de la Pitie, Paris, France
* Address reprint requests to Dr Cabrol, Service de Chirurgie Thoracique et Cardiovasculaire, Hopital de la Pitie, 83, Boulevard de l'Hopital, 75013 Paris, France.
 |
Abstract
|
|---|
A series of 75 cardiac tumors in 74 patients were operated on at La Pitie Hospital between 1972 and 1989. There were 73 primary and 2 metastatic tumors. Among the benign neoplasms, 58 were myxomas; seven of the nine malignant tumors were primary heart tumors. The mean age of the patients was 48 years (range, 9 to 75 years); 46 patients were female and 28 male. Fifty-seven percent of the patients had congestive heart failure, 13% had chest pain, 17% had neurological symptoms, and only 1 patient was totally asymptomatic. The cardiac tumors were incidental findings in 3 patients. Complete resection was carried out in 66 benign lesions and only four of the malignant tumors. All patients survived operation, although 4 died in the early postoperative period. Longterm results were excellent in patients with benign lesions, and no recurrences were found. In patients with malignant tumors, surgical procedures were only palliative and aimed at prolonging life; hence, prognosis remained unchanged.
 |
References
|
|---|
- Straus R, Merliss R. Primary tumors of the heart Arch Pathol 1945;39:74-78.
- Bisel HF, Wroblewski F, LaDue JS. Incidence and clinical presentation of cardiac metastases JAMA 1953;153:712-715.[Medline]
- McAllister HA, Fenoglio JJ. Tumors of the cardiovascular system Atlas of tumor pathology. Washington DC: Armed Forces Institute of Pathology; 1978Fascicle 15, Series 2.
- Bulkley BH, Hutchins GM. Atrial myxoma: a fifty year review Am Heart J 1979;97:639-643.[Medline]
- Reece IJ, Cooley DA, Frazier OH, Hallman GL, Powers PL, Montero CG. Cardiac tumors. Clinical spectrum and prognosis of lesions other than classical benign myxomas in 20 patients J Thorac Cardiovasc Surg 1984;88:439-446.[Abstract]
- Pavie A, Gandjbakhch I, Hallali P, et al. Traitement chirurgical des masses intracardiaques Couer 1984;15:1Pavie A, Gandjbakhch I, Hallali P, et al. Traitement chirurgical des masses intracardiaques Couer 1984;15:31-41.
- Dein JR, Frist WH, Stinson EB, et al. Primary cardiac neoplasms: early and late results of surgical treatment in 42 patients J Thorac Cardiovasc Surg 1987;93:502-511.[Abstract]
- Silvermann NA. Primary cardiac tumors Ann Surg 1980;191:127-138.[Medline]
- Larrieu AJ, Jamieson WRE, Tyers GFO, et al. Primary cardiac tumors J Thorac Cardiovasc Surg 1982;83:339-348.[Abstract]
- Poupeville J. Les tumeurs malignes du coeurParis: These Medecine; 1959.
- Desousa AL, Muller J, Campbell R, Batnitzky S, Rankin L. Atrial myxoma: a review of the neurological complications, metastases and recurrences J Neurol Neurosurg Psychiatry 1978;41:1119.[Abstract/Free Full Text]
- Tipton BK, Robertson JT, Robertson JH. Embolism to the central nervous system from cardiac myxoma: report of two cases J Neurosurg 1977;47:937-940.[Medline]
- Gonzalez A, Altieri PI, Marques E, Cox RA, Castillo M. Massive pulmonary embolism associated with a right ventricular myxoma Am J Med 1980;69:795.[Medline]
- Meller J, Teichholz LE, Pickard AD. Left ventricular myxoma: echocardiographic diagnosis and review of the literature Am J Med 1977;63:816.[Medline]
- Schlosser V, Siebers JW, Kasper W, Bohm N. Vascular tumor in the heart J Cardiovasc Surg 1987;28:132-134.[Medline]
- Goodwin JF. The spectrum of cardiac tumors Am J Cardiol 1968;21:307-314.[Medline]
- Goodwin JF. Diagnosis of left atrial myxoma Lancet 1963;1:464-468.[Medline]
- Haskell RJ, French WJ. Cardiac tamponade as the initial presentation of malignancy Chest 1985;88:70-73.[Medline]
- Wolfe SB, Popp RL, Feigenbaum H. Diagnosis of atrial tumors by ultrasound Circulation 1969;39:615-617.[Abstract/Free Full Text]
- Shumaker Jr HB. Discussion of: Symbas P, Hatcher CR, Gravanis MB. Myxoma of the heart: clinical and experimental observations Ann Surg 1976;18:470-475.
- Donahoo JS, Weiss JL, Gardner TJ. Current management of atrial myxoma with emphasis on a new diagnostic technique Ann Surg 1979;189:763-768.[Medline]
- Boxer RA, La Corte MA, Singh S, et al. Diagnosis of cardiac tumors in infants by magnetic resonance imagine Am J Cardiol 1985;56:831-832.[Medline]
- Pizarello RA, Goldberg SM, Goldman MA, et al. Tumors of the heart diagnosed by magnetic resonance imagine J Am Coll Cardiol 1985:989-991.
- Tsuchiya F, Kohno A, Saitoh R, Shigeta A. CT findings of atrial myxoma Radiology 1984;151:139.[Abstract/Free Full Text]
- Chaloupka JC, Fishman EK, Siegelman SS. Use of CT in the evaluation of primary cardiac tumors Cardiovasc Intervent Radiol 1986;9:132-135.[Medline]
- Attar S, Yu-Chen L, Singleton R, Scherlis L, David R, McLaughlin JS. Cardiac myxoma Ann Thorac Surg 1980;29:397-405.[Abstract/Free Full Text]
- Thomas EK, Winchell CP, Varco RL. Diagnostic and surgical aspects of left atrial tumors J Thorac Cardiovasc Surg 1967;53:535-548.[Medline]
- Hanson EC, Gill CC, Razavi M, Loop FD. The surgical treatment of the atrial myxomas J Thorac Cardiovasc Surg 1985;89:298-303.[Abstract]
- McCarthy PM, Piehler JM, Schaff HV, et al. The significance of multiple, recurrent, and complex cardiac myxomas J Thorac Cardiovasc Surg 1986;91:389-396.[Abstract]
- Kirklin JW, Barratt-Boyes BG. Cardiac surgery. Morphology, diagnostic criteria, natural history, techniques, results and indicationsNew York: Churchill Livingstone; 1988. pp. 1398.
- Bortolotti U, Mazzucco A, Valfre C, Valente M, Pennelli N, Gallucci V. Right ventricular myxoma: review of the literature and report of two patients Ann Thorac Surg 1982;33:277-284.[Abstract/Free Full Text]
- Gerbode F, Kerth WJ, Hill JD. Surgical management of tumors of the heart Surgery 1967;61:94-101.[Medline]
- Read RC, White HJ, Murphy ML, Williams D, Sun CN, Flanagan WH. The malignant potentiality of the left atrial myxoma J Thorac Cardiovasc Surg 1974;68:857-867.[Medline]
- Read RC. Cardiac myxoma and surgical history Ann Thorac Surg 1980;29(5):395-396.[Free Full Text]
- St. John Sutton MG, Lise-Andre M, Guiliani ER, Lie JT. Atrial myxomas. A review of clinical experience in 40 patients6th ed. Mayo Clin Proc. 55. 1980. pp. 371-376.
- Nakazawa S, Yamazaki Y, Yokosawa T, et al. Successful resection of cardiac fibroma with ventricular tachycardia J Cardiovasc Surg 1989;30:44-46.[Medline]
- Williams DB, Danielson GK, McGoon DC, Feldt RH, Edwards WD. Cardiac fibroma. Long-term survival after excision J Thorac Cardiovasc Surg 1982;84:230-236.[Abstract]
- Reyes CV, Jablokow VR. Lipomatous hypertrophy of the interatrial septum Am J Clin Pathol 1979;72:785.[Medline]
- Arciniegas E, Hakimi M, Farooki ZQ, Truccone NJ, Green EW. Primary cardiac tumors in children J Thorac Cardiovasc Surg 1980;79:582-591.[Abstract]
- Maurer ER. Successful removal of tumor of the heart J Thorac Cardiovasc Surg 1952;23:479-485.[Medline]
- Soberman MS, Plauth WH, Winn KJ, Forest GC, Hatcher CR, Sink JD. Hemangioma of the right ventricle causing outflow tract obstruction J Thorac Cardiovasc Surg 1988;96:307-309.[Abstract]
- Janigan DT, Husain A, Robinson NA. Cardiac angiosarcomas. A review and a case report Cancer 1986;57:852-859.[Medline]
- Bearman RM. Primary leiomyosarcoma of the heart Arch Pathol 1974;98:62.[Medline]
- Boggio RR. Primary fibrosarcoma of the heart Arch Pathol Lab Med 1984;108:533.[Medline]
- Kern SE, Cowen ME, Abrams GD. Malignant fibrous histiocytoma of the heart presenting as unilateral pulmonary thromboembolism and infarct Hum Pathol 1985;16:1279-1281.[Medline]
- Laya MB, Maillard JA, Bewtra C, Levin HS. Malignant fibrous histiocytoma of the heart. A case report and review of the literature Cancer 1987;59:1026-1031.[Medline]
- Hall RJ, Cooley DA. Neoplastic heart disease. Malignant primary tumors of the heartIn: Hurst JW, editor. The heart. 6th ed. New York: McGraw-Hill; 1986. pp. 1294-1305.
- Pillai R, Blauth C, Peckham M, Hendry W, Barrett A, Goldstraw P. Intracardiac metastases from malignant teratoma of the testis J Thorac Cardiovasc Surg 1986;92:118-120.[Abstract]
- Becker RC, Loeffler JS, Leopold KA, Underwoor DA. Primary tumors of the heart: a review with emphasis on diagnosis and potential treatment modalities Semin Surg Oncol 1985;1:165-170.
- Kralstein J, Frishman W. Malignant pericardial diseases: diagnosis and treatment Am Heart J 1987;113:785-790.[Medline]
- Longino LA, Meeker IA. Primary cardiac tumors in infancy J Pediatr 1953;43:724-731.[Medline]
- Cham WC, Freiman AH, Carstens PHB, Chu FC. Radiation therapy of cardiac and pericardial metastases Radiology 1975;114:701-704.[Abstract/Free Full Text]
- Figuera D, Pradas G, Burgos R, et al. Es el angiosarcoma primitivo de corazon una indication de trasplante? Presented at the Tenth Congreso National de la Sociedad Espanola de Cirugia Cardiovascular. 1990.
- Sorlie D, Myhre ESP, Stalsberg H. Angiosarcoma of the heart: unusual presentation and survival after treatment Br Heart J 1984;51:94.[Abstract/Free Full Text]
- Rossi NP, Kioschos JM, Aschenbrener CA, Ehrenhaft JL. Primary angiosarcoma of the heart Cancer 1976;37:891.[Medline]
This article has been cited by other articles:

|
 |

|
 |
 
P. Carmona, J. Lazaro, J. Llagunes, and S. Canovas
Primary cardiac neuroendocrine carcinoma and minimally invasive cardiac surgery
Asian Cardiovascular and Thoracic Annals,
December 1, 2012;
20(6):
721 - 723.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
A. B. Animasahun, O. Y. Kushimo, F. A. Fajuyile, and O. F. Njokanma
Atrial Myxoma in 2 Nigerian Children: Case Reports and Review of the Literature
World Journal for Pediatric and Congenital Heart Surgery,
October 1, 2010;
1(3):
397 - 399.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
H. Nishi, M. Mitsuno, M. Ryomoto, H. Hao, S. Hirota, and Y. Miyamoto
Giant Cardiac Lipoma in the Ventricular Septum Involving the Tricuspid Valve
Ann. Thorac. Surg.,
October 1, 2009;
88(4):
1337 - 1339.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
A. W. ElBardissi, J. A. Dearani, R. C. Daly, C. J. Mullany, T. A. Orszulak, F. J. Puga, and H. V. Schaff
Analysis of benign ventricular tumors: Long-term outcome after resection
J. Thorac. Cardiovasc. Surg.,
May 1, 2008;
135(5):
1061 - 1068.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
J.-C. M. Walkes, W. R. Smythe, and M. J. Reardon
Cardiac Neoplasms
,
January 1, 2008;
3(2008):
1479 - 1510.
[Full Text]
|
 |
|

|
 |

|
 |
 
M. Guden, B. Akpinar, M. U. Ergenoglu, E. Sagbas, I. Sanisoglu, and U. Ozbek
Combined Radiofrequency Ablation and Myxoma Resection Through a Port Access Approach
Ann. Thorac. Surg.,
October 1, 2004;
78(4):
1470 - 1472.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
N. Sata, Y. Moriyama, N. Hamada, T. Horinouchi, and K. Miyahara
Recurrent Pericardial Tamponade from Atrial Hemangioma
Ann. Thorac. Surg.,
October 1, 2004;
78(4):
1472 - 1475.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
L.-M. Stevens, H. Lapierre, M. Pellerin, I. El-Hamamsy, D. Bouchard, M. Carrier, and L. P. Perrault
Atrial versus biatrial approaches for cardiac myxomas
Interact CardioVasc Thorac Surg,
December 1, 2003;
2(4):
521 - 525.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
S. Schrepfer, T. Deuse, C. Detter, H. Treede, A. Koops, D. H. Boehm, S. Willems, F. Lacour-Gayet, and H. Reichenspurner
Successful resection of a symptomatic right ventricular lipoma
Ann. Thorac. Surg.,
October 1, 2003;
76(4):
1305 - 1307.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
M. J. Reardon and W. R. Smythe
Cardiac Neoplasms
,
January 1, 2003;
2(2003):
1373 - 1400.
[Full Text]
|
 |
|

|
 |

|
 |
 
J. Jougon, M. N. Laborde, M. Parrens, and T. MacBride
Cystic lymphangioma of the heart mimicking a mediastinal tumor
Eur J Cardiothorac Surg,
September 1, 2002;
22(3):
476 - 478.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
J.-C. Chachques, P. G. Argyriadis, C. Latremouille, N. D'Attellis, P. Fornes, P. Bruneval, J.-P. Couetil, and A. F. Carpentier
Cardiomyoplasty: Ventricular reconstruction after tumor resection
J. Thorac. Cardiovasc. Surg.,
May 1, 2002;
123(5):
889 - 894.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
P.-J. Ko, C.-H. Chang, P. J. Lin, J.-J. Chu, F.-C. Tsai, C. Hsueh, and M.-W. Yang
Video-assisted minimal access in excision of left atrial myxoma
Ann. Thorac. Surg.,
October 1, 1998;
66(4):
1301 - 1305.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
Y.-S. Chang, C.-H. Chang, P. J. Lin, J.-J. Chu, H.-P. Liu, H.-C. Hsieh, F.-C. Tsai, and M.-W. Yang
Video-assisted cardiac surgery for intracardiac tumors
Eur J Cardiothorac Surg,
October 1, 1998;
14(Supplement_1):
S160 - S165.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
A. Bhan, R. Mehrotra, S. K. Choudhary, R. Sharma, D. Prabhakar, B. Airan, A. S. Kumar, and P. Venugopal
Surgical experience with intracardiac myxomas: long-term follow-up
Ann. Thorac. Surg.,
September 1, 1998;
66(3):
810 - 813.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
N. Chakfe, J.-G. Kretz, P. Valentin, B. Geny, H. Petit, S. Popescu, S. Edah-Tally, and G. Massard
Clinical Presentation and Treatment Options for Mitral Valve Myxoma
Ann. Thorac. Surg.,
September 1, 1997;
64(3):
872 - 877.
[Abstract]
[Full Text]
|
 |
|

|
 |

|
 |
 
K. V. N. Kamalakar, S. Jaishankar, T. N. C. Padmanabhan, D. S. Rao, C. Sundaram, G. S. Prakash, A. V. Kumar, P. A. A. A. Jiwani, P. Rajagopal, and A. D. Rakshak
Cardiac Tumors: Eight-Year Experience
Asian Cardiovascular and Thoracic Annals,
March 1, 1997;
5(1):
39 - 42.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
R. K. Suri, R. S. Manjari, N. K. Jha, V. Kim, R. Juneja, and M. Singh
Malignant Fibrous Histiocytoma of the Left Atrium
Asian Cardiovascular and Thoracic Annals,
December 1, 1996;
4(4):
230 - 232.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
L. Lang-Lazdunski, M. Oroudji, Y. Pansard, C. Vissuzaine, and U. Hvass
Successful resection of giant intrapericardial lipoma
Ann. Thorac. Surg.,
July 1, 1994;
58(1):
238 - 241.
[Abstract]
[PDF]
|
 |
|