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Ann Thorac Surg 1991;52:541-543
© 1991 The Society of Thoracic Surgeons

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Articles

Complement activation during bypass in acquired C1 esterase inhibitor deficiency

The Brompton Hospital and King's College Hospital, London, United Kingdom

Accepted for publication January 16, 1991.

^_* Address reprint requests to Mr Bonser, Queen Elizabeth Hospital, Queen Elizabeth Medical Centre, Birmingham B15 2TH, United Kingdom.

	Abstract

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Serial complement estimations during cardiopulmonary bypass are reported in a patient with acquired C1 esterase inhibitor deficiency. Although the extent of classic and alternative pathway activation appeared appropriate, exaggerated common pathway activation with massive increase in the C3d:C3 ratio occurred. A fatal hemostatic disorder, pulmonary edema, and circulatory collapse ensued despite prophylaxis and therapy.

	References

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This Article Abstract Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Personal Folders Download to citation manager Permission Requests Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Bonser, R. S. Articles by Vergani, D. Search for Related Content PubMed PubMed Citation Articles by Bonser, R. S. Articles by Vergani, D.