Ann Thorac Surg 1986;41:507-510
© 1986 The Society of Thoracic Surgeons
Development of Circulating Antiheart Antibodies as a Result of Coronary Bypass Surgery
James R. Baker, Jr., M.D., MAJ, MC, USA,
David J. Cohen, M.D., LTC, MC, USA,
Harold D. Head, M.D., COL, MC, USA,
James L. DeShong, Sp5, USA,
Geoffrey M. Graeber, M.D., LTC, MC, USA*
Departments of Transplant Immunology and Thoracic Surgery, Walter Reed Army Medical Center, the Division of Surgery, Walter Reed Army Institute of Research, Washington, DC, and the Department of Surgery, The Uniformed Services University of the Health Sciences, Bethesda, MD
Accepted for publication July 29, 1985.
* Address reprint requests to Dr. Graeber, Division of Surgery, Walter Reed Army Institute of Research, Walter Reed Army Medical Center, Washington, DC 20307-5100
Antiheart antibodies have been implicated as a marker of postcardiotomy syndrome in patients undergoing coronary artery bypass. To assess the frequency of and contributory factors in the development of antiheart antibodies after coronary bypass procedures, 33 patients were examined for evidence of antiheart antibodies before and for seven days after routine coronary artery bypass operations. Overall titers of antiheart antibodies rose in approximately 66% of the patients. However, this rise was not accompanied by any major clinical symptoms. History of previous myocardial infarction or myocardial injury did not correlate with a higher frequency of development of antibodies. Antiheart antibodies appear to be a common consequence of coronary artery bypass operations and are not routinely associated with the development of postcardiotomy syndrome.
The opinions and assertions contained herein are the private views of the authors and are not to be construed as official or as reflecting the views of the Department of the Army or the Department of Defense.
The authors thank Mrs. Linda G. Ellis for preparation of the manuscript, and Ms. Reneal B. Furguson for technical assistance with the immunofluorescence studies.
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