ATS
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Abstract Freely available
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to Personal Folders
Right arrow Download to citation manager
Right arrow Permission Requests
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Ellis, E. N.
Right arrow Articles by Conti, V. R.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Ellis, E. N.
Right arrow Articles by Conti, V. R.

Ann Thorac Surg 1983;36:167-172
© 1983 The Society of Thoracic Surgeons

Articles

Renal Function in Children Undergoing Cardiac Operations

Eileen N. Ellis, M.D., Ben H. Brouhard, M.D.*, Vincent R. Conti, M.D.

Departments of Pediatrics and Surgery, University of Texas Medical Branch, Galveston, TX

Accepted for publication October 3, 1982.

* Address reprint requests to Dr. Brouhard, Division of Pediatric Nephrology, University of Texas Medical Branch, Galveston, TX 77550


   Abstract
Top
 Abstract
Footnotes
 References
 
Because we sometimes observed large amounts of uric acid crystals in the urine of infants and children after open-heart operations and since renal insufficiency from any cause can be a serious complication of cardiac procedures, 8 acyanotic and 5 cyanotic children were studied prospectively by comparing several preoperative and postoperative measures of renal function. There were no significant differences between the acyanotic and cyanotic groups in terms of age, time on cardiopulmonary bypass, or other preoperative variables. Postoperatively, children in both groups had a wide range of free water clearances (CH2O), with some values in the range reported to be diagnostic of renal insufficiency in adults. Since none of these children had renal insufficiency by other criteria, CH2O may not be as reliable an indicator of renal insufficiency in children. The major difference between the cyanotic and acyanotic groups was seen in postoperative serum uric acid levels (SUA); the mean SUA levels in the acyanotic and cyanotic groups were 5.3 ± 0.5 mg/dl (± standard error of the mean) and 10.4 ± 1.7 mg/dl (range, 8.0 to 15.5 mg/dl), respectively. Since the hyperuricemia in the cyanotic children could not be related to increased exogenous administration or decreased renal excretion, it is probably caused by increased endogenous production and may be related to the resolution of the cyanotic state.


   Footnotes
Top
 Abstract
 Footnotes
References
 
The authors would like to thank Jan Taucer, M.T., for her valuable technical assistance.


   References
Top
 Abstract
 Footnotes
 References
 

  1. Abel RM, Buckley MJ, Austen WG, et al. Etiology, incidence and prognosis of renal failure following cardiac operations J Thorac Cardiovasc Surg 1976;71:323.[Abstract]
  2. Bhat JG, Gluck MC, Lowenstein J, Baldwin OS. Renal failure after open heart surgery Ann Intern Med 1976;84:677.[Medline]
  3. Gailuinas P, Chawla R, Lazarus JM, et al. Acute renal failure following cardiac operations J Thorac Cardiovasc Surg 1980;79:241.[Abstract]
  4. Casali R, Simmons RL, Najarian JS, et al. Acute renal insufficiency complicating major cardiovascular surgery Ann Surg 1975;181:370.[Medline]
  5. Hilberman M, Myers BD, Carrie BJ, et al. Acute failure following cardiac surgery J Thorac Cardiovasc Surg 1979;77:880.[Abstract]
  6. Chesney RW, Kaplan BS, Freedom RM, et al. Acute renal failure: an important complication of cardiac surgery in infants J Pediatr 1975;87:381.[Medline]
  7. Bove EL, Behrendt DM. Open-heart surgery in the first week of life Ann Thorac Surg 1980;29:130.[Abstract/Free Full Text]
  8. Holper K, Shuck E, Sebening F. The diagnosis of acute renal failure (ARF) following cardiac surgery with cardio-pulmonary bypass Thorac Cardiovasc Surg 1979;27:231.[Medline]
  9. Landes RG, Lillehei RC, Lindsay WG, Nicoloff DM. Free-water clearance and the early recognition of acute renal insufficiency after cardiopulmonary bypass Ann Thorac Surg 1976;22:41.[Abstract/Free Full Text]
  10. Heimann T, Brau S, Sakurai H, Pierce II EC. Urinary osmolal changes in renal dysfunction following open-heart operations Ann Thorac Surg 1976;22:44.[Abstract/Free Full Text]
  11. Baek SM, Brown RS, Shoemaker WC. Early prediction of acute renal failure and recovery: sequential measurements of free water clearance Ann Surg 1973;177:253.[Medline]
  12. Heimann T, Brau S, Sakurai H, Pierce EC. Acid base changes in renal dysfunction following open heart surgery Mt Sinai J Med NY 1978;45:471.[Medline]
  13. Bourgeois BFD, Donath A, Paunier L, Rouge JC. Effects of cardiac surgery on renal function in children J Thorac Cardiovasc Surg 1979;77:283.[Abstract]
  14. Brans YW, Dweck HS, Harris HB, et al. Effect of open heart surgery on the body composition of infants and young children Pediatr Res 1981;15:1024.[Medline]
  15. Hilberman M, Derby GC, Spenar RJ, Stinson EB. Sequential pathophysiological changes characterizing the progression from renal dysfunction to acute renal failure following cardiac operation J Thorac Cardiovasc Surg 1980;79:838.[Abstract]
  16. Edelmann CM. Pediatric Kidney Disease. Boston: Little, Brown; 1978. pp. 219.
  17. Passwell J, Orda S, Bush M, Boichis H. Uric acid excretion in infancy Adv Exp Med Biol 1974;41B:753.[Medline]
  18. Harkness RA, Nicol AD. Plasma uric acid levels in children Arch Dis Child 1969;44:773.[Free Full Text]
  19. Brenner BM, Rector FC. The Kidney. Second edition. Philadelphia: Saunders; 1981. pp. 582-584pp 1023–1045.
  20. Woolliscroft JO, Colfer H, Fox IH. Hyperuricemia in acute illness: a poor prognostic sign Am J Med 1982;72:58.[Medline]
  21. Yu T. Secondary gout associated with myeloproliferative diseases Arthritis Rheum 1965;8:765.[Medline]
  22. Gold MS, Williams JC, Spivack M, Grann V. Sickle cell anemia and hyperuricemia JAMA 1968;206:1572.[Medline]
  23. Diamond HS, Meisee A, Sharon E, et al. Hyperuricosuria and increased tubular secretion of urate in sickle cell anemia Am J Med 1975;59:796.[Medline]



This article has been cited by other articles:


Home page
 Eur J Heart FailHome page
L. E. Spieker, F. T. Ruschitzka, T. F. Luscher, and G. Noll
The management of hyperuricemia and gout in patients with heart failure
Eur J Heart Fail, August 1, 2002; 4(4): 403 - 410.
[Full Text] [PDF]

This Article
Right arrow Abstract Freely available
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to Personal Folders
Right arrow Download to citation manager
Right arrow Permission Requests
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Ellis, E. N.
Right arrow Articles by Conti, V. R.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Ellis, E. N.
Right arrow Articles by Conti, V. R.