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Ann Thorac Surg 1980;30:281-284
© 1980 The Society of Thoracic Surgeons


Articles

Positive End-Expiratory Pressure in the Management of the Patient with a Postoperative Bleeding Heart

Patricio A. Ilabaca, M.D., John L. Ochsner, M.D.*, Noel L. Mills, M.D.

From the Department of Surgery, Ochsner Medical Institutions, New Orleans, LA

Accepted for publication February 25, 1980.

* Address reprint requests to Dr. Ochsner, Ochsner Clinic, 1514 Jefferson Hwy, New Orleans, LA 70121


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 Abstract
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This prospective study involves 406 consecutive adults who had heart operation with extracorporeal circulation. Fifteen patients (3.7%) bled at the rate of 200 ml per hour or more in the postoperative period. Thirteen of the 15 patients who bled had undergone coronary artery operation.

After all clotting factors and, when applicable, hypertension had been checked and corrected, positive end-expiratory pressure (PEEP) was used in managing the bleeding of these patients. Before institution of PEEP, the average bleeding was 330 ml per hour for one to five hours. After PEEP was instituted in the 11 patients in whom bleeding was controlled, an average output of 25 ml per hour for one to ten hours was recorded. Patients were kept on PEEP for five to ten hours.

In 7 patients hemorrhage was controlled with 10 cm H2O of PEEP; 4 required 15 cm of PEEP to stop bleeding; 3 were explored for continuous bleeding on 15 cm of PEEP; and 1 was explored because of hypotension on 15 cm of PEEP. In 11 of the 15 patients who bled postoperatively (73%), operation was avoided by judicious use of PEEP. We believe that PEEP increases mediastinal pressure and that the overdistended lung can obliterate some bleeding in the mediastinum, thus controlling bleeding in many of these patients.


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  1. Bachmann F, McKenna R, Cole ER, et al. The hemostatic mechanisms after open heart surgery: I. Studies on plasma coagulation factors and fibrinolysis in 52 patients after ECC J Thorac Cardiovasc Surg 1975;70:76.[Abstract]
  2. Bick RL, Arbegast N, Crawford L, et al. Hemostatic defects induced by cardiopulmonary bypass Vasc Surg 1975;9:228.[Medline]
  3. Blomback M, Noren I, Senning Å. Coagulation disturbances during extracorporeal circulation and the postoperative period Acta Chir Scand 1964;127:433.[Medline]
  4. Falke KJ, Pontoppidan H, Kumar A, et al. Ventilation with end expiratory pressure in acute lung disease J Clin Invest 1972;51:2315.[Medline]
  5. Kevy SV, Glickman RM, Bernhard WF, et al. The pathogenesis and control of the hemorrhagic defect in open heart surgery Surg Gynecol Obstet 1966;123:313.[Medline]
  6. Mammen EF. Natural proteinase inhibitors in extracorporeal circulation Ann NY Acad Sci 1968;146:754.[Medline]
  7. Mills NL, Ochsner JL. Technique of internal mammary-to-coronary artery bypass Ann Thorac Surg 1974;17:237.[Abstract/Free Full Text]
  8. Powers SR, Mannal R, Neclerio M, et al. Physiologic consequences of positive end expiratory pressure (PEEP) ventilation Ann Surg 1973;178:265.[Medline]
  9. Sugarman HJ, Rogers RM, Miller LD. Positive end-expiratory pressure (PEEP): indications and physiologic considerations Chest 1972;62:865.
  10. Trimble AS, Herst R, Grady M, et al. Blood loss in open heart surgery Arch Surg 1966;93:323.[Medline]
  11. Wright TA, Darte J, Mustard WT. Postoperative bleeding after extracorporeal circulation Can J Surg 1959;2:142.[Medline]



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