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Ann Thorac Surg 1980;30:230-239
© 1980 The Society of Thoracic Surgeons


Articles

Stresses of Natural versus Prosthetic Aortic Valve Leaflets in Vivo

Mano Thubrikar, Ph.D.*, William C. Piepgrass, M.D., J. David Deck, Ph.D., Stanton P. Nolan, M.D.

From the Departments of Surgery and Anatomy, University of Virginia Medical Center, Charlottesville, VA

Accepted for publication January 30, 1980.

* Address reprint requests to Dr. Thubrikar, Box 263, Surgical Research Laboratory, University of Virginia Medical Center, Charlottesville, VA 22908


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During normal function of the aortic valve, the aortic leaflets undergo not only cyclic loading and unloading but also cyclic reversal of their curvature. The stresses induced in the leaflet due to these variations have been computed using a new concept based on the structure of the leaflet. Membrane stresses have been related to the pressure difference across the leaflet and bending stresses to the leaflet curvature. Total stresses were obtained by adding the two stresses. Total stresses in bioprosthetic and synthetic leaflets also were computed using the same approach. In systole, the natural leaflet is subjected to much lower total stress than a bioprosthetic or a synthetic leaflet. The natural leaflet is not subjected to compressive stresses during the cardiac cycle, whereas bioprosthetic and synthetic leaflets must sustain compressive stresses during systole. The differences in stress patterns of these leaflets indicate that there is a difference in their longevity.


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Supported by Grants HL-17969 and HL-16935 from the National Institutes of Health.

Presented at the 31st Annual Conference on Engineering in Medicine and Biology, Oct 21–25, 1978, Atlanta, GA.


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  1. Broom ND. Fatigue-induced damage in glutaraldehyde-preserved heart valve tissue J Thorac Cardiovasc Surg 1978;76:202.[Abstract]
  2. Cataloglu A, Clark RE, Gould PL. Stress analysis of aortic valve leaflets with smoothed geometrical data J Biomech 1977;10:153.[Medline]
  3. Chong KP, Wieting DW, Hwang WHC, Kennedy JH. Stress analysis of normal human aortic valve leaflets during diastole Biomater Med Devices Artif Organs 1973;1:307.
  4. Driscol TE, Eckstein RW. Systolic pressure gradients across the aortic valve and in the ascending aorta Am J Physiol 1965;209:557.[Abstract/Free Full Text]
  5. Ghista DN, Reul H, Ray G, Chandran KB. Optimal design of aortic leaflet prosthesis J Engineering Mechanics Division 1978;104:97.
  6. Harvey JF. Theory and Design of Modern Pressure Vessels. New York: Van Nostrand Reinhold; 1974. pp. 32.
  7. Harvey JF. Theory and Design of Modern Pressure Vessels. New York: Van Nostrand Reinhold; 1974. pp. 93-95.
  8. Swanson WM, Clark RE: Motion and stresses in aortic valve leaflets during systole. Am Soc Mechanical Engineers Publication No. 72-WA/BHF-5, Nov, 1972.
  9. Swanson WM, Clark RE. Dimensions and geometric relationships of the human aortic valve as a function of pressure Circ Res 1974;35:871.[Abstract/Free Full Text]
  10. Thubrikar M, Bosher LP, Nolan SP. The mechanism of opening of the aortic valve J Thorac Cardiovasc Surg 1979;77:863.[Abstract]
  11. Thubrikar M, Harry RR, Nolan SP. Normal aortic valve function in dogs Am J Cardiol 1977;40:563.[Medline]
  12. Thubrikar M, Piepgrass WC, Bosher LP, Nolan SP: The elastic modulus of canine aortic valve leaflets in vivo and in vitro. Circ Res (in press).



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