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Ann Thorac Surg 1979;27:17-23
© 1979 The Society of Thoracic Surgeons

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Articles

III. Local Cardiac Hypothermia: Experimental Comparison of Shumway's Technique and Perfusion Cooling

Cardiac Research Unit, Killingbeck Hospital, Leeds, United Kingdom

Accepted for publication February 15, 1978.

^* Address reprint requests to Dr. Rosenfeldt, The Baker Medical Research Institute, Commercial Rd, Prahran, Victoria 3181, Australia.

	Abstract

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A model of the thermal conditions of the heart during ischemic arrest was used to study the efficiency of Shumway's technique of topical hypothermia. Cooling was improved by increasing the flow of cold saline to 350 ml per minute, reducing the saline temperature, lifting the posterior left ventricular wall away from the pericardium, and irrigating the left ventricular cavity. Perfusing the coronary circulation with cold fluid cooled the heart eight times faster than did surface irrigations by Shumway's technique.

	Footnotes

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Supported by the National Heart Research Fund of Great Britain.

We wish to thank Professor S. Dugdale, Department of Physics, Leeds University, for much help with the thermodynamic interpretation of the data, and Mr. P. Deverell, F.R.C.S., and Mr. M. V. Braimbridge, F.R.C.S., for advice. Particular thanks is due to Mrs. S. Fortune for technical assistance.

	References

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3. Bretschneider HJ, Hubener G, Knoll D, et al. Myocardial resistance and tolerance to ischemia: physiological and biochemical basis J Cardiovasc Surg 1975;16:241.[Medline]
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7. Hearse DJ, Stewart DA, Braimbridge MV. Cellular protection during myocardial ischemia: the development and characterization of a procedure for the induction of reversible ischemic arrest Circulation 1976;54:193.[Abstract/Free Full Text]
8. Kirsch U, Rodewald G, Kalmar P. Induced ischemic arrest J Cardiovasc Surg 1972;63:121.
9. Mulder DG, Olinger GN, McConnell DH, et al. Myocardial protection during aortic valve replacement Ann Thorac Surg 1976;21:123.[Abstract/Free Full Text]
10. Nelson RL, Goldstein MS, McConnell DH, et al. Improved myocardial performance after aortic cross-clamping by combining pharmacological arrest with topical hypothermia Circulation 1976;51(Suppl 3):111-112.
11. Rosenfeldt FL, Watson DA: Development of an in vitro model of myocardial cooling: a study of the effect of cardiac size on cooling rate. Ann Thorac Surg, pp 7-12, this issue.
12. Rosenfeldt FL, Watson DA: Interference with local myocardial cooling by heat gain during aortic cross-clamping. Ann Thorac Surg, pp 13-16, this issue.
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