ATS
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Abstract Freely available
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to Personal Folders
Right arrow Download to citation manager
Right arrow Permission Requests
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Dennis, R. C.
Right arrow Articles by Valeri, C. R.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Dennis, R. C.
Right arrow Articles by Valeri, C. R.

Ann Thorac Surg 1978;26:17-26
© 1978 The Society of Thoracic Surgeons

Articles

Transfusion of 2,3 DPG-Enriched Red Blood Cells to Improve Cardiac Function

Richard C. Dennis, M.D., Herbert B. Hechtman, M.D., Robert L. Berger, M.D.*, Louis Vito, M.D., Richard D. Weisel, M.D., C. Robert Valeri, CAPT, MC, USNR

Department of Surgery, Boston University Medical Center, and The Naval Blood Research Laboratory, Boston, MA

Accepted for publication December 2, 1977.

* Address reprint requests to Dr. Berger, University Hospital, 75 E Newton St, Boston, MA 02118


   Abstract
Top
 Abstract
Footnotes
 References
 
Attempts were made to enhance oxygen availability in patients undergoing coronary artery bypass operations by transfusing red blood cells enriched in 2,3 diphosphoglycerate (2,3 DPG) to 150% of normal. In this study of 22 patients, 11 received red blood cells with high 2,3 DPG levels and 11 received red blood cells with 70% of normal 2,3 DPG levels (control).

Immediately following cardiopulmonary bypass the 11 patients who received high 2,3 DPG red blood cells had a P50 value of 31.6 mm Hg; the value in control patients was 28.3 mm Hg (p < 0.05). Oxygen consumption values were 135 and 106 ml/min/m2, respectively (p < 0.05). Mixed venous oxygen tensions were similar in the two groups, but the arteriovenous content difference was higher in the high 2,3 DPG group (p < 0.05). Cardiac indices increased significantly in response to a fluid load in the high 2,3 DPG group compared with controls at comparable filling pressures. We believe the improved myocardial performance in response to a fluid challenge is a result of increased oxygen availability.


   Footnotes
Top
 Abstract
 Footnotes
References
 
The opinions or assertions contained herein are those of the authors and are not to be construed as official or reflecting the views of the Navy Department or Naval Service at large.

Supported by the US Navy (Naval Medical Research and Development Command Research Task No. MR041.02.01-0017A2GE), National Institute of General Medical Sciences Grant #5P01-GM-17366-05, and the Norwich Thoracic Surgical Fund.

We gratefully acknowledge the assistance of HM3 James C. Sammons, USN, Stephanie Schwartz, Carolyn Malin, Marilyn Sullivan, Jan Noone, Linda Pivacek, and Marie Rogers.


   References
Top
 Abstract
 Footnotes
 References
 

  1. Bertman NA. Temperature coefficients for pCO2 and pO2 in bloods with varying acid-base states J Appl Physiol 1968;24:225.[Free Full Text]
  2. Bordiuk JM, McKenna PJ, Giannelli Jr S, et al. Alterations in 2,3 diphosphoglycerate and O2 hemoglobin affinity in patients undergoing open-heart surgery Circulation 1971;43:141.
  3. Cooper N, Brazier JR, Hottenrott C, et al. Myocardial depression following citrated blood transfusion Arch Surg 1973;107:756.[Medline]
  4. Ebert PA, Greenfield LJ, Austen WG, et al. Experimental comparison of methods for protecting the heart during aortic occlusion Ann Surg 1962;155:25.[Medline]
  5. Katz LN, Feinberg H. The relation of cardiac effort to myocardial oxygen consumption and coronary flow Circ Res 1958;6:656.[Abstract/Free Full Text]
  6. Kelman GR. Calculation of certain indices of cardiopulmonary function using a digital computer Resp Physiol 1966;1:335.[Medline]
  7. Kelman GR, Nunn JF. Nomograms for correction of blood pO2, pCO2, pH and base excess for time and temperature J Appl Physiol 1966;21:1484.[Free Full Text]
  8. Sanmarco ME, Marquez LA, Hall C, et al. Myocardial contractility following cardiopulmonary bypass with and without myocardial ischemia Ann Thorac Surg 1969;8:237.[Free Full Text]
  9. Shappell SD, Murray JA, Nasser MG, et al. Acute change in hemoglobin affinity for oxygen during angina pectoris N Engl J Med 1970;282:1219.[Medline]
  10. Valeri CR. Oxygen transport function of preserved red cells Clin Haematol 1974;3:649.
  11. Valeri CR, Zaroulis CG. Rejuvenation and freezing of outdated stored human red cells N Engl J Med 1972;287:1307.[Medline]
  12. Valeri CR, Zaroulis CG, Marchionni L, et al. A simple method for measuring oxygen content in blood J Lab Clin Med 1972;79:1035.[Medline]
  13. Weisel RD, Berger RL, Hechtman HB. Current concepts: measurement of cardiac output by thermodilution N Engl J Med 1975;292:682.[Medline]
  14. Weisel RD, Vito L, Dennis RC, et al. Clinical applications of thermodilution cardiac output determinations Am J Surg 1975;129:449.[Medline]
  15. Willman VL, Howard HS, Cooper T, et al. Ventricular function after hypothermic cardiac arrest Arch Surg 1961;82:120.[Medline]
  16. Willerson JT, Powell WJ, Guiney Jr T, et al. Improvement in myocardial function and coronary blood flow in ischemic myocardium after mannitol J Clin Invest 1972;51:2989.[Medline]
  17. Young JA, Lichtman MA, Cohen J. Reduced red cell 2,3 diphosphoglycerate and adenosine triphosphate, hypophosphatemia, and increased hemoglobin-oxygen affinity after cardiac surgery Circulation 1973;47:1313.[Abstract/Free Full Text]



This article has been cited by other articles:


Home page
 StrokeHome page
H. Kimura, N. Hamasaki, M. Yamamoto, and M. Tomonaga
Circulation of Red Blood Cells Having High Levels of 2,3-Bisphosphoglycerate Protects Rat Brain From Ischemic Metabolic Changes During Hemodilution
Stroke, August 1, 1995; 26(8): 1431 - 1437.
[Abstract] [Full Text]

Home page
 Ann. Thorac. Surg.Home page
C. R. Valeri, M. Yarnoz, J. J. Vecchione, R. C. Dennis, J. Anastasi, D. A. Valeri, L. E. Pivacek, H. B. Hechtman, C. P. Emerson, and R. L. Berger
Improved Oxygen Delivery to the Myocardium during Hypothermia by Perfusion with 2,3 DPG-Enriched Red Blood Cells
Ann. Thorac. Surg., December 1, 1980; 30(6): 527 - 535.
[Abstract] [PDF]

This Article
Right arrow Abstract Freely available
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to Personal Folders
Right arrow Download to citation manager
Right arrow Permission Requests
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Dennis, R. C.
Right arrow Articles by Valeri, C. R.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Dennis, R. C.
Right arrow Articles by Valeri, C. R.