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Ann Thorac Surg 1974;17:63-98
© 1974 The Society of Thoracic Surgeons

Articles

Deep Hypothermia in Cardiovascular Surgery

Edward A. Rittenhouse, M.D., Hitoshi Mohri, M.D.*, David H. Dillard, M.D, K. Alvin Merendino, M.D.

Department of Surgery and the First Surgical Service of the University Hospital, University of Washington School of Medicine, Seattle, Wash

* Address reprint requests to Dr. Mohri, Department of Surgery, University of Washington School of Medicine, Seattle, Wash. 98195


   Abstract
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 Abstract
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Recent experimental studies and clinical application of deep hypothermia for cardiovascular surgery are reviewed. At most institutions, surface hypothermia alone or in combination with limited cardiopulmonary bypass has been employed. Circulatory dynamics were well maintained following prolonged cardiac arrest at 20°C. Some degree of acidosis usually developed after the arrest period but was gradually corrected during rewarming. Total circulatory occlusion could be maintained for at least one hour at 20°C. without evidence of cerebral damage in infants. Many complex congenital cardiac anomalies, including transposition of the great arteries, total anomalous pulmonary venous return, ventricular septal defect, and tetralogy of Fallot, have been successfully corrected in the first few weeks of life. Less encouraging results have been achieved in patients with infradiaphragmatic total anomalous pulmonary venous return, complete atrioventricular canal, or pulmonary atresia.


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Basic studies of hypothermia were aided by Grants PGHS-POI-HL13517, Unit 7; NICHDH.D. 02274; and grants from the American Heart Association and Washington State Heart Association.


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