HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Personal Folders Download to citation manager Permission Requests Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Stafford-Smith, M. Search for Related Content PubMed PubMed Citation Articles by Stafford-Smith, M. Related Collections Extracorporeal circulation Related Article

Ann Thorac Surg 2006;82:1488
© 2006 The Society of Thoracic Surgeons

---

Original Articles: Cardiovascular

Invited commentary

Department of Anesthesiology, Duke University Medical Center, Box 3094 DUMC, Durham, NC 27710

(Email: staff002{at}mc.duke.edu).

A recent publication of conclusions from the Second International Consensus Conference of the Acute Dialysis Quality Initiative (ADQI) Group includes a review of the 12 leading acute renal failure animal models [1]. Notably, a single renal insult from ischemia, toxins, or inflammation characterizes almost all of these models, and none involve cardiopulmonary bypass. The same authors acknowledge the disappointing and sometimes misleading contribution of these animal models to the investigation of human acute renal injury and renal protection in the critically ill, including cardiac surgical patients.

In this context, new acute renal injury models involving multiple sources of insult, including bypass, are particularly interesting [2], including most recently that by Singal and colleagues [3]. The hope is that these models may resemble more closely the multiple sources and variable infliction of insults already known to characterize the pathophysiology of cardiac surgery–related acute renal dysfunction and that this new methodology may improve the value of animal models in the search for useful human interventions. Notably, these new bypass models may be even more relevant when aging or baseline renal-impaired animals are subjected to similar conditions.

	References

Top References

 

1. Bellomo R, Ronco C, Kellum JA, Mehta RL, Palevsky P, Acute Dialysis Quality Initiative workgroup Acute renal failure—definition, outcome measures, animal models, fluid therapy and information technology needs: the Second International Consensus Conference of the Acute Dialysis Quality Initiative (ADQI) Group Crit Care 2004;8:R204-R212.[Medline]
2. Sulzer C, de Lange F, Yates R, Phillips-Bute B, Stafford-Smith M, Mackensen GB. Renal dysfunction after deep hypothermic circulatory arrest in the rat Anesth Analg 2006 2006;102:SCA41.
3. Singal RK, Docking LM, Girling LG, et al. Biologically variable bypass reduces enzymuria after deep hypothermic circulatory arrest Ann Thorac Surg 2006;82:1480-1488.[Abstract/Free Full Text]

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Personal Folders Download to citation manager Permission Requests Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Stafford-Smith, M. Search for Related Content PubMed PubMed Citation Articles by Stafford-Smith, M. Related Collections Extracorporeal circulation Related Article