Ann Thorac Surg 1996;61:1061
© 1996 The Society of Thoracic Surgeons
Discussion
Discussion
See also page 1055.
DR HARVEY I. PASS (Bethesda, MD): Did you document whether pentoxifylline inhibited TNF production by your graft, which may play a great part in the results? Also, would you plan on comparing the efficacy of pentoxifylline versus antibody against TNF or TNF receptor blockade?
DR YAMASHITA:Pentoxifylline has an anti-TNF effect, but, unfortunately, we did not assess TNF levels. Therefore, we cannot comment in detail about its anti-TNF effect.
DR IRVING L. KRON (Charlottesville, VA): This is a very well done study. I have one question for you. Are you blocking the lung injury or are you blocking the effects of the Euro-Collins solution? We have demonstrated in our laboratory, as have other laboratories, that Euro-Collins solution has a deleterious effect on the pulmonary vascular endothelium. Could you speculate whether you would see this type of improvement if you used a solution such as low-potassium dextran as your preservation solution?
DR YAMASHITA:Of course, we are aware of your work. I cannot answer your question specifically because we did not use a low-potassium dextran solution. However, this is a severe ischemia-reperfusion model with all flow and ventilation directed to the allograft. My suspicion is that under these conditions, the results with low-potassium dextran would not be greatly different than those we observed with modified Euro-Collins solution.
Related Article
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Pentoxifylline in Flush Solution Improves Early Lung Allograft Function
- Motohiro Yamashita, Ralph A. Schmid, Kan Okabayashi, Koei Ando, Jun Kobayashi, Joel D. Cooper, and G. Alexander Patterson
Ann. Thorac. Surg. 1996 61: 1055-1061.
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[Full Text]
