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Correspondence

YC-1 Induced Constrictions: No Dependency on Other Vasoconstrictor

^a Department of Cardiothoracic and Vascular Surgery, Ulm University Medical Center, Steinhövelstr 9, 89075 Ulm, Germany
^b Department of Cardiothoracic Surgery, University of Regensburg Medical Center, Franz-Josef-Strauss-Allee 11, 93053 Regensburg, Germany

Stephan Hirt, MD^b

^b Department of Cardiothoracic Surgery, University of Regensburg Medical Center, Franz-Josef-Strauss-Allee 11, 93053 Regensburg, Germany

(Email: markus.hoenicka{at}uniklinik-ulm.de).

To the Editor:

We greatly appreciate the invited commentary of Dr Feng [1] regarding our article "Endothelium-Dependent Vasoconstriction in Isolated Vessel Grafts: A Novel Mechanism of Vasospasm?" [2]. Dr Feng's comments are very helpful in putting the mechanism outlined in our study into the greater context of relaxing and vasoconstricting mechanisms in the vessel wall. Unfortunately, Dr Feng misinterpreted 1 critical detail of our study design. This led him to state that the use of norepinephrine-preconstricted vessels distracts from the main theme of the study. We would like to clarify that the vessels that were used to investigate the constricting properties of YC-1 were not preconstricted. Instead, YC-1 was added to the vessels at their resting tensions, and YC-1–induced constrictions did not depend on previous or concomitant constriction with another substance. Therefore the YC-1 dose-response curves of our study provide the information that Dr Feng requests in his comment. Vessels were preconstricted with norepinephrine in only 1 type of experiment that was designed to demonstrate the vasorelaxing properties of YC-1.

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1. Feng J. Invited commentary Ann Thorac Surg 2011;92:1307.[Free Full Text]
2. Hoenicka M, Keyser A, Rupprecht L, Puehler T, Hirt S, Schmid C. Endothelium-dependent vasoconstriction in isolated vessel grafts: a novel mechanism of vasospasm? Ann Thorac Surg 2011;92:1299-1307.[Abstract/Free Full Text]

This article has been cited by other articles:

				J. Feng Reply. Ann. Thorac. Surg., May 1, 2012; 93(5): 1762 - 1762. [Full Text] [PDF]

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Personal Folders Download to citation manager Author home page(s): Stephan Hirt Permission Requests Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Hoenicka, M. Articles by Hirt, S. Search for Related Content PubMed PubMed Citation Articles by Hoenicka, M. Articles by Hirt, S. Related Collections Cardiac - pharmacology Related Article