Ann Thorac Surg 2009;88:205. doi:10.1016/j.athoracsur.2009.05.015
© 2009 The Society of Thoracic Surgeons
Original Articles: General Thoracic
Invited Commentary
Eddie Hoover, MD
Department of Surgery (112), Buffalo VAMC, 3495 Bailey Ave, Buffalo, NY 14215
(Email: eddie.hoover{at}med.va.gov).
The question posed by Riquet and colleagues [1] and the basis for this article was the role of surgical intervention in patients with isolated, intrathoracic hilar/mediastinal lymph node metastases from extrathoracic malignancies. Of 565 such patients reviewed, 37 had a history of extrathoracic malignancies, and 11 were excluded when a biopsy specimen showed unrelated pathology. Of the remaining 26 patients, operations were done for diagnostic purposes in 15 patients who had breast, prostate, kidney, and laryngeal cancers, and melanoma. That left 11 patients with six different extrathoracic primaries who underwent lymphadenectomy as a curative procedure. Multiple stations were removed in 5 patients and single stations in 6, with genitourinary tract lesions accounting for the most cases.
The authors correctly point out that the mechanism of spread of disease into the thorax from extrathoracic tumors is poorly understood for the most part, except for pelvic and renal lesions. Their 5-year survival rate was 41.6%, but 6 of the 11 died after an average of 21.6 months. This difference could be explained by selection bias, because the resected patients had more limited disease. In fact, the only long-term survivors, at 134 and 110 months, were 2 patients with testicular cancers, both of which were noted to have "evolved into mature tissue" after resection. The patient with breast cancer survived for 61 months, but it is quite possible that the same outcome could have been obtained with chemotherapy.
Perhaps the major concern with this article is that the authors compared 11 patients who met criteria and who had resectable disease with 15 patients who did not, which is not a valid comparison. They concluded that, "these metastatic lesions may be isolated and that resection can be done safely with benefits to selected patients." It is not possible to make a strong case for surgical intervention because the authors have not established that patients with resectable disease could not have had the same survival without an operation by using other forms of adjuvant therapy.
To begin with, the number for the entire group is too small. The authors cover the literature well for these rare lesions, but unfortunately, the information provided here cannot be generalized over a broad spectrum of extrathoracic lesions. Not enough patients were included, and the successful cases reported are largely anecdotal, or even worse, if one considers the skew imposed by the 2 patients with testicular cancer. Therefore, the original intent of elucidating the role of surgical intervention in these patients, unfortunately, remains unanswered. Surgeons should exercise extreme caution when recommending a surgical procedure and decide each case on its merits.
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References
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- Riquet M, Berna P, Brian E, et al. Intrathoracic lymph node metastases from extrathoracic carcinoma: the place for surgery Ann Thorac Surg 2009;88:200-205.[Abstract/Free Full Text]
Related Article
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Intrathoracic Lymph Node Metastases From Extrathoracic Carcinoma: The Place for Surgery
- Marc Riquet, Pascal Berna, Emmanuel Brian, Alain Badia, Claudia Vlas, Patrick Bagan, and Françoise Le Pimpec Barthes
Ann. Thorac. Surg. 2009 88: 200-205.
[Abstract]
[Full Text]
[PDF]
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