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Ann Thorac Surg 2008;86:1725. doi:10.1016/j.athoracsur.2008.06.008
© 2008 The Society of Thoracic Surgeons
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Correspondence

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Cameron D. Wright, MD

Massachusetts General Hospital, Department of Thoracic Surgery, Blake 1570, 55 Fruit St, Boston, MA 02114

(Email: wright.cameron{at}mgh.harvard.edu).

To the Editor:

I thank Cohn [1] for commenting on our article regarding the treatment of locally advanced thymic tumors. I am gratified to hear that his patient who was treated in a multimodality fashion is well in long-term follow-up. What remains to be seen is which type of induction therapy is warranted in patients with these advanced tumors, chemotherapy alone or concurrent chemoradiotherapy. As mentioned, both in our article and in the accompanying editorial by Huang and colleagues [2], only long-term follow-up of prospective trials will give us information as to what type of induction strategy is best, and perhaps there might be specific thymic tumors that are better treated one way and others the opposite way [3]. What is most important is the recognition of an advanced tumor preoperatively, and referral for induction therapy to maximize the chance of a complete resection.


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  1. Cohn HE. Successful long-term outcome in locally advanced Masaoka IVA thymoma with induction chemotherapy followed by complete resection and adjuvant radiotherapy(letter) Ann Thorac Surg 2008;86:1725.[Free Full Text]
  2. Huang J, Riely GJ, Rosenzweig KE, Rusch VW. Multimodality therapy for locally advanced thymomas: state of the art or investigational therapy? Ann Thorac Surg 2008;85:365-367.[Free Full Text]
  3. Wright CD, Choi NC, Wain JC, Mathisen DJ, Lynch TJ, Fidias P. Induction chemoradiotherapy followed by resection for locally advanced Masaoka stage III and IVA thymic tumors Ann Thorac Surg 2008;85:385-389.[Abstract/Free Full Text]

Related Article

Successful Long-Term Outcome in Locally Advanced Masaoka IVA Thymoma With Induction Chemotherapy Followed by Complete Resection and Adjuvant Radiotherapy
Herbert E. Cohn
Ann. Thorac. Surg. 2008 86: 1725. [Extract] [Full Text] [PDF]




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