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Correspondence

Successful Long-Term Outcome in Locally Advanced Masaoka IVA Thymoma With Induction Chemotherapy Followed by Complete Resection and Adjuvant Radiotherapy

Jefferson Medical College of Thomas Jefferson University, 1025 Walnut St, Suite 607 College, Philadelphia, PA 19107

(Email: herbert.cohn{at}jefferson.edu).

To the Editor:

I reviewed with interest the article by Wright and colleagues [1]. I would like to add to their series a patient that I operated on 8 years ago.

She was referred for treatment as an inoperable malignant thymoma. After conducting a multidisciplinary evaluation, which included, myself, a medical oncologist, we recommended a course of combined chemotherapy, surgical resection, and postoperative radiation therapy. After her ovaries were harvested, for future in-vitro fertilization, she received four cycles of cyclophoshamide, cisplatin, and prednisone. She was then deemed suitable for resection. At operation a malignant thymoma, lymphocytic predominant, that was invasive of pericardium, phrenic nerve, lingula of lung, with multiple pleural implants was completely resected. She received adjuvant radiation therapy to a total dose of 52.8 Gy. The pathologic specimen showed extensive central degenerative changes secondary to the preoperative therapy. Two years later she underwent in vitro fertilization and had an uncomplicated pregnancy with delivery of a normal baby. At most recent follow-up this year she remains tumor free. I congratulate the authors on their success with this challenging group of patients, and concur that multimodality therapy is certainly indicated with an anticipated favorable outcome in the majority.

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1. Wright CD, Choi NC, Wain JC, Mathisen DJ, Lynch TJ, Fidias P. Induction chemoradiotherapy followed by resection for locally advanced Masaoka stage III and IVA thymic tumors Ann Thorac Surg 2008;85:385-389.[Abstract/Free Full Text]

This article has been cited by other articles:

				C. D. Wright Reply Ann. Thorac. Surg., November 1, 2008; 86(5): 1725 - 1725. [Full Text] [PDF]

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Personal Folders Download to citation manager Author home page(s): Herbert E. Cohn Permission Requests Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Cohn, H. E. Search for Related Content PubMed PubMed Citation Articles by Cohn, H. E. Related Collections Mediastinum Related Article