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Key References

Gene Therapy in Thoracic Oncology

University of Texas MD Anderson Cancer Center, Department of Thoracic and Cardiovascular Surgery, Houston, Texas

^_* Address correspondence to Dr Roth, University of Texas MD Anderson Cancer Center, Department of Thoracic and Cardiovascular Surgery, PO Box 301402, Unit 445, Houston, TX 77230-1402 (Email: jroth{at}mdanderson.org).

	Gene Therapy for Lung Cancer

Top Introduction Gene Therapy for Lung... Gene Therapy for Esophageal... Gene Therapy for Mesothelioma

 

1 Nguyen DM, Spitz FR, Yen N, Cristiano RJ, Roth JA. Gene therapy for lung cancer: Enhancement of tumor suppression by a combination of sequential systemic cisplatin and adenovirus-mediated p53 gene transfer. J Thorac Cardiovasc Surg 1996;112:1372–6.

2 Claudio PP, Howard CM, Pacilio C, et al. Mutations in the retinoblastoma-related gene RB2/p130 in lung tumors and suppression of tumor growth in vivo by retrovirus-mediated gene transfer. Cancer Res 2000;60:372–82.

3 Inoue A, Narumi K, Matsubara N, et al. Administration of wild-type p53 adenoviral vector synergistically enhances the cytotoxicity of anti-cancer drugs in human lung cancer cells irrespective of the status of p53 gene. Cancer Lett 2000;157:105–12.

4 Heike Y, Takahashi M, Kanegae Y, Sato Y, Saito I, Saijo N. Interleukin-2 gene transduction into freshly isolated lung adenocarcinoma cells with adenoviral vectors. Hum Gene Ther 1997;8:1–14.

5 Dubinett SM, Miller PW, Sharma S, Batra RK. Gene therapy for lung cancer. Hematol Oncol Clin North Am 1998;12:569–94.

6 Albelda SM. Gene therapy for lung cancer and mesothelioma. Chest 1997;111:S144–9.

7 Miller PW, Sharma S, Stolina M, et al. Dendritic cells augment granulocyte-macrophage colony-stimulating factor (GM-CSF)/herpes simplex virus thymidine kinase-mediated gene therapy of lung cancer. Cancer Gene Ther 1998;5:380–9.

8 Moon C, Oh Y, Roth JA. Current status of gene therapy for lung cancer and head and neck cancer. Clinic Cancer Res 2003;9:5055–67.

9 Batra RK, Olsen JC, Pickles RJ, Hoganson DK, Boucher RC. Transduction of non-small cell lung cancer cells by adenoviral and retroviral vectors. Am J Respir Cell Mol Biol 1998;18:402–10.

10 Frederiksen KS, Petri A, Abrahamsen N, Poulsen HS. Gene therapy for lung cancer. Lung Cancer 1999;23:191–207.

11 Gopalan B, Ito I, Branch CD, Stephens C, Roth JA, Ramesh R. Nanoparticle based systemic gene therapy for lung cancer: molecular mechanisms and strategies to suppress nanoparticle-mediated inflammatory response. Technol Cancer Res Treat 2004;3:647–57.

12 Guo HL, Epperly MW, Bernarding M, et al. Manganese superoxide dismutase-plasmid/liposome (MnSOD-PL) intratracheal gene therapy reduction of irradiation-induced inflammatory cytokines does not protect orthotopic Lewis lung carcinomas. In Vivo 2003;17:13–21.

13 Lee JC, Park KH, Han SJ, et al. Inhibitory effect of adenovirus-uteroglobin transduction on the growth of lung cancer cell lines. Cancer Gene Ther 2003;10:287–93.

14 Scheule RK. Gene therapy for lung cancer—an application for cationic lipid-mediated gene delivery? J Natl Cancer Inst 1998;90:1118–9.

15 Antonia SJ, Sotomayor E. Gene therapy for lung cancer. Curr Opin Oncol 2000;12:138–42.

16 Haura EB, Sotomayor E, Antonia SJ. Gene therapy for lung cancer. Mol Biotechnol 2003;25:139–48.

17 Ruttinger D, Winter H, van den Engel NK, et al. Immunotherapy of lung cancer: an update. Onkologie 2006;29:33–8.

18 Cui R, Takahashi K, Takahashi F, Tanabe KK, Fukuchi Y. Endostatin gene transfer in murine lung carcinoma cells induces vascular endothelial growth factor secretion resulting in up-regulation of in vivo tumorigenecity. Cancer Lett 2006;232:262–71.

19 Escudier B, Andre F, Baldeyrou P, Le Cesne A, Le Chevalier T, Tursz T. Gene therapy and lung cancer: today and tomorrow. Revue des Maladies Respiratoires 2000;17:363–70.

20 Suzuki E, Kapoor V, Jassar AS, Haas A, Kaiser LR, Albelda SM. Augmentation of immuno-gene therapy for lung cancer using chemotherapy. Mol Ther 2004;9:S215–6.

21 Vattemi E, Claudio PP. Current status of gene therapy for lung cancer. Drugs Future 2005;30:1017–30.

22 Wilderman MJ, Kim S, Gillespie CT, et al. Blockade of TNF-alpha decreases both inflammation and efficacy of intrapulmonary Ad.IFN beta immunotherapy in an orthotopic model of bronchogenic lung cancer. Mol Ther 2006;13:910–7.

23 Nemunaitis J, Swisher SG, Timmons T, et al. Adenovirus-mediated p53 gene transfer in sequence with cisplatin to tumors of patients with non-small-cell lung cancer. J Clin Oncol 2000;18:609–22.

24 Ramesh R, Saeki T, Templeton NS, et al. Successful treatment of primary and disseminated human lung cancers by systemic delivery of tumor suppressor genes using an improved liposome vector. Mol Ther 2001;3:337–50.

25 Roth JA, Nguyen D, Lawrence DD, et al. Retrovirus-mediated wild-type p53 gene transfer to tumors of patients with lung cancer. Nat Med 1996;2:985–91.

26 Swisher SG, Roth JA, Nemunaitis J, et al. Adenovirus-mediated p53 gene transfer in advanced non-small cell lung cancer. J Natl Cancer Inst 1999;91:763–71.

27 Weill D, Mack M, Roth J, et al. Adenoviral-mediated p53 gene transfer to non-small cell lung cancer through endobronchial injection. Chest 2000;118:966–70.

28 Saeki T, Mhashilkar A, Swanson X, et al. Inhibition of human lung cancer growth following adenovirus-mediated mda-7 gene expression in vivo. Oncogene 2002;21:4558–66.

29 Ji L, Nishizaki M, Gao B. Expression of several genes in the human chromosome 3p21.3 homozygous deletion region by an adenovirus vector results in tumor suppressor activities in vitro and in vivo. Cancer Res 2002;62:2715–20.

30 Oida Y, Gopalan B, Miyahara R. Sulindac enhances Ad-mda7/IL-24 mediated apoptosis: a novel therapeutic strategy for human lung cancer. Mol Cancer Ther 2005;4:291–304.

31 Ito I, Ji L, Tanaka F, et al. Liposomal vector mediated delivery of the 3p FUS1 gene demonstrates potent antitumor activity against human lung cancer in vivo. Cancer Gene Ther 2004;11:733–9.

32 Roth JA. Adenovirus p53 gene therapy. Expert Opin Biol Ther 2006;6:55–61.

33 Pataer A, Fanale MA, Roth JA, Swisher SG, Hunt KK. Induction of apoptosis in human lung cancer cells following treatment with amifostine and an adenoviral vector containing wild-type p53. Cancer Gene Ther 2006;13:806–14.

34 Antonia SJ, Mirza N, Fricke I, et al. Combination of p53 cancer vaccine with chemotherapy in patients with extensive stage small cell lung cancer. Clin Cancer Res 2006;12:878–87.

35 Shimada H, Matsubara H, Shiratori T, et al. Phase I/II adenoviral p53 gene therapy for chemoradiation resistant advanced esophageal squamous cell carcinoma. Cancer Sci 2006;97:554–61.

36 Fujiwara T, Tanaka N, Kanazawa S, et al. Multicenter phase I study of repeated intratumoral delivery of adenoviral p53 in patients with advanced non-small-cell lung cancer. J Clin Oncol 2006;24:1689–99.

37 Tolcher AW, Hao D, de Bono J, et al. Phase I, pharmacokinetic, and pharmacodynamic study of intravenously administered Ad5CMV-p53, an adenoviral vector containing the wild-type p53 gene, in patients with advanced cancer. J Clin Oncol 2006;24:2052–8.

38 Wilderman MJ, Sun J, Jassar AS, et al. Intrapulmonary IFN-beta gene therapy using an adenoviral vector is highly effective in a murine orthotopic model of bronchogenic adenocarcinoma of the lung. Cancer Res 2005;65:8379–87.

	Gene Therapy for Esophageal Cancer

Top Introduction Gene Therapy for Lung... Gene Therapy for Esophageal... Gene Therapy for Mesothelioma

 

39 Zhou P, Jiang W, Zhang YJ, et al. Antisense to cyclin D1 inhibits growth and reverses the transformed phenotype of human esophageal cancer-cells. Oncogene 1995;11:571–80.

40 Ishii H, Dumon KR, Vecchione A, et al. Effect of adenoviral transduction of the fragile histidine triad gene into esophageal cancer cells. Cancer Res 2001;61:1578–84.

41 Schrump DS, Chen GA, Consuli U, Jin XM, Roth JA. Inhibition of esophageal cancer proliferation by adenovirally mediated delivery of p16(INK4). Cancer Gene Ther 1996;3:357–64.

42 Epperly MW, Gretton JA, Defilippi SJ, et al. Modulation of radiation-induced cytokine elevation associated with esophagitis and esophageal stricture by manganese superoxide dismutase-plasmid/liposome (SOD2-PL) gene therapy. Radiat Res 2001;155:2–14.

43 Heideman DAM, Snijders PJF, Craanen ME, et al. Selective gene delivery toward gastric and esophageal adenocarcinoma cells via EpCAM-targeted adenoviral vectors. Cancer Gene Ther 2001;8:342–51.

44 Stickle RL, Epperly MW, Klein E, Bray JA, Greenberger JS. Prevention of irradiation-induced esophagitis by plasmid/liposome delivery of the human manganese superoxide dismutase transgene. Radiat Oncol Investig 1999;7:204–17.

45 Epperly MW, Sikora C, Defilippi S, et al. Plasmid/liposome transfer of the human manganese superoxide dismutase transgene prevents ionizing irradiation-induced apoptosis in human esophagus organ explant culture. Int J Canc 2000;90:128–37.

46 Epperly MW, Kagan VE, Sikora CA, et al. Manganese superoxide dismutase-plasmid/liposome (MnSOD-PL) administration protects mice from esophagitis associated with fractionated radiation. Int J Canc 2001;96:221–31.

47 Gu ZP, Wang YJ, Li JG, Zhou YA. VEGF(165) antisense RNA suppresses oncogenic properties of human esophageal squamous cell carcinoma. World J Gastroenterol 2002;8:44–8.

48 Shimada H, Matsubara H, Shiratori T, et al. Phase I/II adenoviral p53 gene therapy for chemoradiation resistant advanced esophageal squamous cell carcinoma. Cancer Sci 2006;97:554–61.

	Gene Therapy for Mesothelioma

Top Introduction Gene Therapy for Lung... Gene Therapy for Esophageal... Gene Therapy for Mesothelioma

 

49 Sterman DH, Recio A, Vachani A, et al. Long-term follow-up of patients with malignant pleural mesothelioma receiving high-dose adenovirus herpes simplex thymidine kinase/ganciclovir suicide gene therapy. Clin Cancer Res 2005;11:7444–53.

50 Kruklitis RJ, Singhal S, DeLong P, Kapoor V, Sterman DH, Kaiser LR, Albelda SM. Immuno-gene therapy with interferon-beta before surgical debulking delays recurrence and improves survival in a murine model of malignant mesothelioma. J Thorac Cardiovasc Surg 2004;127:123–30.

51 Odaka M, Sterman DH, Wiewrodt R, et al. Eradication of intraperitoneal and distant tumor by adenovirus-mediated interferon-beta gene therapy is attributable to induction of systemic immunity. Cancer Res 2001;61:6201–12.

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Personal Folders Download to citation manager Author home page(s): Jack A. Roth Permission Requests Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Roth, J. A. Search for Related Content PubMed PubMed Citation Articles by Roth, J. A. Related Collections Lung - cancer Molecular biology Esophagus - cancer