ATS
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Ann Thorac Surg 2008;85:1564-1569. doi:10.1016/j.athoracsur.2008.02.014
© 2008 The Society of Thoracic Surgeons
This Article
Right arrow Abstract Freely available
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to Personal Folders
Right arrow Download to citation manager
Right arrow Author home page(s):
Paul Herijgers
Right arrow Permission Requests
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Hill, E. E.
Right arrow Articles by Herijgers, P.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Hill, E. E.
Right arrow Articles by Herijgers, P.
Related Collections
Right arrow Valve disease
Right arrowRelated Article

Original Articles: Adult Cardiac

Outcome of Patients Requiring Valve Surgery During Active Infective Endocarditis

Evelyn E. Hill, MDa, Marie-Christine Herregods, MD, PhDb, Steven Vanderschueren, MD, PhDa, Piet Claus, PhDb, Willy E. Peetermans, MD, PhDa, Paul Herijgers, MD, PhDc,*

a Department of Internal Medicine–Infectious Diseases, K.U. Leuven, University Hospital Gasthuisberg, Leuven, Belgium
b Department of Cardiology, K.U. Leuven, University Hospital Gasthuisberg, Leuven, Belgium
c Department of Cardiac Surgery, K.U. Leuven, University Hospital Gasthuisberg, Leuven, Belgium

Accepted for publication February 1, 2008.

* Address correspondence to Dr Herijgers, Department of Cardiac Surgery, K.U. Leuven, University Hospital Gasthuisberg, Herestraat 49, B-3000 Leuven, Belgium (Email: paul.herijgers{at}med.kuleuven.be).


   Abstract
Top
 Abstract
Introduction
 Patients and Methods
 Results
 Comment
 References
 
Background: The optimal timing of cardiac operations in patients with infective endocarditis continues to be debated. This observational study analyzed the profile and outcome of patients with active infective endocarditis undergoing operations.

Methods: Between June 2000 and June 2006, 95 surgically treated patients with definite infective endocarditis by the modified Duke criteria were included.

Results: Fifty-eight patients were operated on within the first 7 days after diagnosis of infective endocarditis and 37 at more than 7 days after diagnosis up to immediately after completion of antibiotic treatment. Staphylococci predominated and were significantly associated with embolism, abscess, and septic shock. The most frequent indication for operation was severe regurgitation with heart failure. The 6-month mortality was 15%. Early operation showed a trend towards increased mortality vs late operation. In univariable analysis, factors associated with 6-month mortality included staphylococci and septic shock. Multivariable analysis revealed that septic shock predicted 6-month mortality. Despite early operation in patients experiencing septic shock, 57% died. No patients without heart failure died after undergoing (early or late) procedures for severe regurgitation.

Conclusions: The prognosis in surgically treated patients was determined by the occurrence of septic shock. The outcome in patients who underwent late operations was favorable compared with the early group. This difference was probably not due to the timing of the surgical intervention but to the severity of infective endocarditis. In patients with severe regurgitation without heart failure, early operation may offer benefit in length of hospitalization and prevention of development of new heart failure.


   Introduction
Top
 Abstract
 Introduction
Patients and Methods
 Results
 Comment
 References
 
The percentage of surgical intervention in patients with infective endocarditis (IE) in previous series varied from 18% to 63%, depending of the hospital setting. Increasingly, clinicians tend to proceed to operation [1–7]. The favorable outcome of valve surgery for IE in previous series has contributed considerably to this evolving trend [1, 2], although this was recently challenged [8].

The timing of operation is still a matter of debate. Surgical intervention is optimally performed before severe hemodynamic disability or spread of the infection to perivalvular tissue [9]. Previous studies have shown that patients for whom early operation would be associated with a better outcome included patients with staphylococcal prosthetic valve endocarditis (PVE) [10–12]; however, other studies did not confirm that early valve replacement was associated with improved overall outcome in patients with Staphylococcus aureus PVE [13].

Most previous studies defined early or urgent cardiac operation as a procedure performed before termination of antibiotic treatment [14, 15]. In this study we wanted to differentiate more in this nonhomogenous patient group. We therefore defined early operation as surgical intervention within 7 days after diagnosis of IE and late operation as an intervention occurring more than 7 days after diagnosis of IE up to immediately after completion of antibiotic therapy. This 6-year observational cohort study aimed to investigate the profile and outcome of patients undergoing valvular operation for active IE.


   Patients and Methods
Top
 Abstract
 Introduction
 Patients and Methods
Results
 Comment
 References
 
Patient Selection
Between June 2000 and June 2006, we prospectively collected 256 consecutive patients, aged older than 16 years, with definite IE according to the modified Duke's criteria [16], in a tertiary referral center. The present report studied 95 surgically treated patients with left-sided IE. These patients underwent cardiac operation according to predefined criteria for surgical intervention [17]. All patients were treated according to the American Heart Association guidelines [18] and were seen by a cardiologist, cardiac surgeon, and infectious diseases physician. When the microorganism had not been identified at admission, patients with native valve IE received antimicrobial therapy with flucloxacillin, ampicillin, and gentamicin, and patients with prosthetic valve IE (PVE) received antimicrobial therapy with vancomycin, gentamicin, and rifampicin. The Ethics Committee approved this study and waived the need for individual patient consent.

We excluded 2 patients with postponed cardiac operation due to cerebral bleeding and 3 patients with perioperatively detected IE. One patient who initially decided to refuse operation was excluded. The study excluded 26 patients who were referred to our center more than 7 days after initiation of adequate antibiotic therapy.

Data Collection
All data were prospectively collected in a database following a predefined protocol and independently reviewed by 3 experts [7].

Cardiac Operation
Cardiac surgical interventions were performed according to predefined criteria [17]. Indications included severe valvular regurgitation with and without heart failure, abscess or perivalvular extension, failure of conservative medical treatment, and large vegetations exceeding 10 mm with high risk of embolization or (recurrent) embolization during antibiotic treatment.

Complications before and after surgical intervention and IE-related outcome up to 6 months follow-up were registered.

Definitions
Nosocomial IE was defined as IE occurring more than 72 hours after admission to the hospital or IE acquired in association with a significant invasive procedure performed during a recent hospitalization within 8 weeks before this hospitalization [2].

Prosthetic valve endocarditis was classified as early PVE within 12 months after cardiac operation and late PVE after 12 months [11].

Early cardiac operation was defined as surgical intervention within the first 7 days after diagnosis of IE and late cardiac operation as a procedure more than 7 days after diagnosis of IE up to immediately after completion of antibiotic treatment. The definition of "early" operation in most published studies was "valve replacement during the course of antimicrobial therapy." However, the early operation groups consisted of patients who were operated on within the first week of antimicrobial therapy up to the end of antibiotic therapy. The clinical profile of patients requiring cardiac operation within the first week of antimicrobial therapy might have differed from patients in whom intervention was performed in the last week before the end of antimicrobial therapy. Therefore, we aimed to divide this heterogenous group and decided to choose a cutoff of 7 days. If IE is associated with destructive and aggressive microorganisms, complications occur mainly early during the course of IE compared with low-virulent pathogens.

Statistical Analysis
Continuous data are presented as medians and interquartile ranges (IQR), unless stated otherwise. Continuous variables were compared with the Mann-Whitney U test and categoric variables with the {chi}2 test or the Fisher exact test. To assess linearity, the quadratic age effect was introduced in the model and was not statistically significant. Variables that tended to be significantly associated with early operation or death in univariable analysis were included in the multivariable logistic regression analysis. Multivariable logistic regression analysis was performed to identify independent factors for early operation and death. The significance level used in univariable and multivariable analysis was p < 0.05. All the reported p values were two-sided. Statistical analysis was performed with the SPSS 12.0 software (SPSS Inc, Chicago, IL).


   Results
Top
 Abstract
 Introduction
 Patients and Methods
 Results
Comment
 References
 
Clinical Characteristics
The study included 95 IE patients, with a median age of 65 years (IQR, 54 to 73 years) and a male/female ratio of nearly 3/2. Of the 95 patients, 59 were referred to our hospital. Prosthetic valves were involved in 23 patients, of whom 11 underwent early operation and 12 late procedures. Nosocomial IE was present in 18 patients. The most frequent comorbid conditions were chronic obstructive pulmonary disease (COPD) in 11 patients and diabetes mellitus in 8 patients.

Staphylococci predominated and were the causative microorganisms in 35 patients. Methicillin-resistant Staphylococcus aureus (MRSA) was present in 4 patients. Streptococci were reported in 23 patients, followed by enterococci in 20 patients. Fifteen patients had culture-negative IE, and 2 patients had other microorganisms, namely, 1 with Pseudomonas aeruginosa and 1 with Escherichia coli. The mitral valve was affected in 56 patients and the aortic valve in 46 patients. Seven patients had multiple valve involvement (aortic and mitral).

Surgical Characteristics
Operations were done in 36 patients because of severe regurgitation with heart failure, in 26 because of severe regurgitation without heart failure, in 13 because of abscess or perivalvular extension, in 11 due to large vegetations exceeding 10 mm with high risk of embolization or (recurrent) embolization during antibiotic treatment, and in 9 due to failure of conservative medical treatment. The median time from diagnosis to operation was 5 days (IQR, 2 to 14 days). Early operations were done in 58 patients, late operations in 37, and emergency operations (≤ 24 hours after diagnosis) in 16.

Twenty-two aortic root repairs were performed. In 17 patients, a Bentall procedure was done with the proximal suture line often low in the outflow tract to exclude all abscesses; and in 5 patients, the aortic root was reconstructed with pericardial patches. During operation, 52 mechanical valves, 42 biologic valves, and 14 homografts were inserted. Three tricuspid and 14 mitral valve repairs were performed. The biologic valves included 20 CE-Pericardial (Carpentier-Edwards, Irvine, CA), 9 Mosaic (Medtronic, Minneapolis, MN), 7 St. Jude Epic (St. Jude Medical, St. Paul, MN), 3 Mitroflow (Sorin Group, Burnaby, BC, Canada), 1 Freestyle (Medtronic), 1 Labcor (Labcor Laboratories, Belo Horizonte-MG, Brazil) and 1 Shelhigh prosthetic valve (Shelhigh Inc, Union, NJ). The mechanical valves included 39 St. Jude HP or Regent (St. Jude Medical), 11 CarboMedics Reduced (Sorin), and 2 Omnicarbon (MedicalCV, Grove Heights, MN). Rings used during valve repair included 14 CarboMedics Annuloflo and 1 Classic Carpentier. For mechanical valves and stented bioprosthesis, we used mattress sutures with pledgets and for Shelhigh conduits and homografts we used single nonpledget sutures.

The median aortic cross-clamp time was 96 minutes (IQR, 71 to 120 minutes). The median cardiopulmonary bypass time was 135 minutes (IQR, 97 to 168 minutes). A significant association was found between the presence of an abscess and the aortic cross-clamp time (p < 0.001) as well with the cardiopulmonary bypass time (p < 0.001). There was no significant association between preoperative septic shock and the aortic cross-clamp time (p = 0.1) or with the cardiopulmonary bypass time (p = 0.2). Two patients required a balloon pump.

Complications
One or more major preoperative complication, including congestive heart failure, septic shock, or cardiogenic shock, was present in 40 patients; and one or more major postoperative complication, including congestive heart failure, septic shock, cardiogenic shock, or surgical reintervention, was observed in 23 patients. An abscess was present in 36 patients. Tables 1 and 2 Go summarize preoperatively and postoperatively diagnosed complications, respectively. Some complications were significantly associated with the causative pathogen. These data are presented in Table 3. In particular, the rate of embolism was highest in staphylococcal IE (p = 0.007). Abscess formation was also significantly associated with staphylococcal IE (p < 0.001), as was an association with septic shock (p = 0.001). Congestive heart failure was most frequently present in the group of other microorganisms (p = 0.004).


View this table:
[in this window]
[in a new window]

  		Table 1 Preoperatively Diagnosed Complications
 

View this table:
[in this window]
[in a new window]

  		Table 2 Postoperatively Diagnosed Complications
 

View this table:
[in this window]
[in a new window]

  		Table 3 Complications According to the Causative Microorganism
 
Outcome
The 6-month mortality rate was 15% (14 of 95). Table 4 presents mortality rates according to clinical characteristics. Mortality was significantly higher in IE caused by staphylococci than from the other pathogens (p = 0.02). No patients with culture-negative IE died. The mortality rate did not differ significantly between the 8 of 59 patients (14%) who were referred to this hospital and the 6 of 36 patients (17%) who were immediately admitted to this hospital (p = 0.7). There was no significant difference in mortality rate between the indications for cardiac operation (p = 0.2); notably, no patients with severe regurgitation without heart failure died. Both patients who required a balloon pump died. A significant association was found between death and the aortic cross-clamp time (p = 0.049) and a nearly significant association with the cardiopulmonary bypass time (p = 0.051).


View this table:
[in this window]
[in a new window]

  		Table 4 Mortality According to Clinical Characteristics
 
When the factor timing of cardiac operation was studied as a continuous variable, there was a nearly significant association with death (p = 0.09). When the timing of cardiac surgery was analyzed as a categoric variable with a cutoff of 7 days between early and late surgery, again a nearly significant association with death was found (p = 0.07). The highest mortality rate was 21% and was observed in the patients (12 of 58) who had early operations vs 5% in the late group (2 of 37; Fig 1). The mortality rate was 19% (3 of 16) in the true emergencies (≤ 24 hours) and 21% (9 of 42) in the remaining early patients. No patients died during the operation.


Figure 1
View larger version (11K):
[in this window]
[in a new window]

  		Fig 1. Six-month survival in patients with early (dashed line) and late operation (solid line).

 
Variables that were analyzed for studying predictors of 6-month mortality included age, sex, PVE, nosocomial origin, comorbid conditions (diabetes mellitus, chronic obstructive pulmonary disease, cancer and immunosuppression), the causative microorganism, the timing of cardiac operation, and the complications, including cardiogenic shock, septic shock, embolism, heart failure, the presence of an abscess, severe regurgitation (≥ 3/4), and prosthetic valve dehiscence. In univariable analysis, factors associated with 6-month mortality in surgically treated patients were staphylococci (p = 0.006) and septic shock (p < 0.001, Table 5). Multivariable logistic regression revealed that septic shock (odds ratio, 11.9; 95% confidence interval, 2.4 to 59.1; p = 0.002) was independently associated with 6-month mortality. All patients who experienced preoperative septic shock belonged to the early operation group, of whom 4 of 7 (57%) died.


View this table:
[in this window]
[in a new window]

  		Table 5 Clinical Characteristics Associated With 6-Month Mortality
 

   Comment
Top
 Abstract
 Introduction
 Patients and Methods
 Results
 Comment
References
 
The principal dilemma is whether to operate early to limit the risk of emboli and of severe cardiac insufficiency, or to delay surgical intervention until resolution of the infection to reduce the risk of operation and of relapse of IE. Previous studies compared early valve replacement vs medical treatment. The definition of "early" operation varied between the studies from "valve replacement during the course of antimicrobial therapy" to "surgery during the initial hospitalization for IE" [5, 10, 13]. Moreover, the early operation group consisted of patients who were operated on within the first week of antimicrobial therapy up to the end of antibiotic therapy. The clinical profile of patients requiring cardiac operation within the first week of antimicrobial therapy probably differed from patients who underwent operations in the last week before the end of antimicrobial therapy. Revilla and colleagues [15] found no significant difference in mortality between urgently (before antibiotic treatment has ended) and electively (at completion of antibiotic treatment) operated on patients. They stated, however, that patients with IE who needed an operation before antibiotic treatment had ended had a poor clinical course.

The present study aimed to investigate the clinical profile and predictors of outcome of patients requiring cardiac operation and studied the impact of timing of cardiac surgical intervention on 6-month mortality. The study included 95 surgically treated IE patients, and their overall 6-month mortality rate was 15%. According to our results, diabetes mellitus did not influence prognosis. In contrast, Chu and colleagues [19] identified diabetes mellitus as an independent risk factor for death; however, their data were from a study that included medically and surgically treated patients. Despite a higher mortality rate of prosthetic than of native valve endocarditis, the presence of a prosthetic valve did not appear to be a predictor of death. Staphylococci were the predominant causative microorganisms and were associated with the highest mortality rate. Only in univariate analysis was there a significant association between staphylococci and death. However, staphylococcal IE was associated with embolism, abscess formation, and septic shock, concluding that staphylococci are indirectly predictors of an unfavorable clinical course and outcome.

When we evaluated the impact of timing of cardiac surgery on mortality, we found a nearly significant association by univariate analysis; however, this difference might have been significant if more patients had been involved in this study. The prognosis in patients who were operated on more than 7 days after diagnosis of IE was relatively favorable because only 5% died. In contrast, in patients in whom the intervention was performed within 7 days of diagnosis of IE, the mortality rate was more than a fourfold higher. Likely, this difference was not due to the timing of the cardiac operation itself but to the severity of the disease.

Congestive heart failure, the most common indication for operation in this study, was not significantly associated with death. As well, Revilla and colleagues [15] found that congestive heart failure, also the main cause of urgent operation, was not significantly associated with death in patients with an early procedure. Their explanation for this finding was that heart failure is caused by a localized problem at the valve that can be treated successfully by surgical intervention.

In studying predictors of death in surgically treated patients, we found that septic shock was an independent predictive factor of 6-month mortality. In contrast to congestive heart failure, septic shock represents uncontrolled systemic and disseminated infection. This unfavorable clinical status cannot be resolved by a local cardiac intervention and may explain why septic shock was associated with a high mortality rate. Patients experiencing preoperative septic shock had a very high mortality rate despite undergoing early cardiac operation.

In this series, no patients with the indication for operation of "severe regurgitation without heart failure" died. These results may suggest that early operation in patients with severe regurgitation without heart failure may be beneficial: outcome results were similar to the late surgically treated group, and the length of hospitalization may be shorter than in patients with an elective operation later during or at the end of antimicrobial therapy. Moreover, new heart failure developed during antibiotic therapy in more than one-fifth of patients who underwent a late operation, which might have been avoided by an early cardiac intervention.

Limitations of this study are that it lacked a randomized controlled treatment strategy. This study reported findings of a single tertiary-care referral center, resulting in limitations to the generalization of the results. Owing to the relative low number of patients included in this study and the low mortality rate, some risk factors might not have reached statistical significance.

In conclusion, septic shock predicted 6-month mortality, and even by performing early cardiac intervention in patients with a preoperative septic shock, the mortality rate remained considerable. The prognosis in patients who were operated on late was favorable compared with those who had an early operation, but this difference was probably not due to the timing of the intervention but to the severity of IE.

Only in patients without life-threatening complications, such as severe regurgitation without heart failure, is the discussion about early or late operation meaningful. Our results show that the outcome did not differ between early and late operation in patients with severe regurgitation without heart failure. Therefore in these patients, early operation may offer benefit in length of hospitalization and prevention of development of new heart failure. However, future and larger studies are needed to convincingly pass a verdict in this topic.


   References
Top
 Abstract
 Introduction
 Patients and Methods
 Results
 Comment
 References
 

  1. Hoen B, Alla F, Selton-Suty C, et al. Changing profile of infective endocarditis—results of a 1-year survey in France JAMA 2002;288:75-81.[Abstract/Free Full Text]
  2. Mouly S, Ruimy R, Launay O, et al. The changing clinical aspects of infective endocarditis: Descriptive review of 90 episodes in a french teaching hospital and risk factors for death J Infect 2002;45:246-256.[Medline]
  3. Loupa C, Mavroidi N, Boutsikakis I, et al. Infective endocarditis in Greece: a changing profile. Epidemiological, microbiological and therapeutic data. Clin Microbiol Infect 2004;10:556-561.[Medline]
  4. Cecchi E, Forno D, Imazio M, et al. New trends in the epidemiological and clinical features of infective endocarditis: results of a multicenter prospective study Ital Heart J 2004;5:249-256.[Medline]
  5. Cabell CH, Abrutyn E, Fowler Jr VG, et al. Use of surgery in patients with native valve infective endocarditis: results from the International Collaboration on Endocarditis Merged Database Am Heart J 2005;150:1092-1098.[Medline]
  6. Miro JM, Anguera I, Cabell CH, et al. Staphylococcus aureus native valve infective endocarditis: report of 566 episodes from the International Collaboration on Endocarditis Merged Database Clin Infect Dis 2005;41:507-514.[Medline]
  7. Hill EE, Herijgers P, Claus P, Vanderschueren S, Herregods MC, Peetermans WE. Infective endocarditis: changing epidemiology and predictors of 6-month mortality: a prospective cohort study Eur Heart J 2007;28:196-203.[Abstract/Free Full Text]
  8. Tleyjeh IM, Ghomrawi HM, Steckelberg JM, et al. The impact of valve surgery on 6-month mortality in left-sided infective endocarditis Circulation 2007;115:1721-1728.[Abstract/Free Full Text]
  9. Mylonakis E, Calderwood SB. Medical progress: Infective endocarditis in adults N Engl J Med 2001;345:1318-1330.[Free Full Text]
  10. Habib G, Tribouilloy C, Thuny F, et al. Prosthetic valve endocarditis: who needs surgery?. A multicentre study of 104 cases. Heart 2005;91:954-959.[Abstract/Free Full Text]
  11. Horstkotte D, Follath F, Gutschik E, et al. Guidelines on prevention, diagnosis and treatment of infective endocarditis-Executive summary Eur Heart J 2004;25:267-276.[Free Full Text]
  12. Wang A, Pappas P, Anstrom KJ, et al. The use and effect of surgical therapy for prosthetic valve infective endocarditis: a propensity analysis of a multicenter, international cohort Am Heart J 2005;150:1086-1091.[Medline]
  13. Chirouze C, Cabell CH, Fowler VG, et al. Prognostic factors in 61 cases of Staphylococcus aureus prosthetic valve infective endocarditis from the international collaboration on endocarditis merged database Clin Infect Dis 2004;38:1323-1327.[Medline]
  14. Aksoy O, Sexton DJ, Wang A, et al. Early surgery in patients with infective endocarditis: a propensity score analysis Clin Infect Dis 2007;44:364-372.[Medline]
  15. Revilla A, López J, Vilacosta I, et al. Clinical and prognostic profile of patients with infective endocarditis who need urgent surgery Eur Heart J 2007;28:65-71.[Abstract/Free Full Text]
  16. Li JS, Sexton DJ, Mick N, et al. Proposed modifications to the Duke criteria for the diagnosis of infective endocarditis Clin Infect Dis 2000;30:633-638.[Medline]
  17. Moon MR, Stinson EB, Miller DC. Surgical treatment of endocarditis Prog Cardiovasc Dis 1997;40:239-264.[Medline]
  18. Baddour LM, Wilson WR, Bayer AS, et al. Infective endocarditis: diagnosis, antimicrobial therapy, and management of complications: a statement for healthcare professionals from the Committee on Rheumatic Fever, Endocarditis, and Kawasaki Disease, Council on Cardiovascular Disease in the Young, and the Councils on Clinical Cardiology, Stroke, and Cardiovascular Surgery and Anesthesia, American Heart Association: endorsed by the Infectious Diseases Society of America Circulation 2005;111:3167-3184.[Abstract/Free Full Text]
  19. Chu VH, Cabell CH, Benjamin Jr DK, et al. Early predictors of in-hospital death in infective endocarditis Circulation 2004;109:1745-1749.[Abstract/Free Full Text]

Related Article

Invited Commentary
Carlos A. Mestres
Ann. Thorac. Surg. 2008 85: 1569-1570. [Extract] [Full Text] [PDF]



This article has been cited by other articles:


Home page
 ICVTSHome page
S. Rekik, I. Trabelsi, I. Maaloul, M. Hentati, A. Hammami, I. Frikha, M. Ben Jemaa, and S. Kammoun
Short- and long-term outcomes of surgery for active infective endocarditis: a Tunisian experience
Interactive CardioVascular and Thoracic Surgery, August 1, 2009; 9(2): 241 - 245.
[Abstract] [Full Text] [PDF]

Home page
 Eur J Heart FailHome page
G. Nadji, D. Rusinaru, J.-P. Remadi, A. Jeu, C. Sorel, and C. Tribouilloy
Heart failure in left-sided native valve infective endocarditis: characteristics, prognosis, and results of surgical treatment
Eur J Heart Fail, July 1, 2009; 11(7): 668 - 675.
[Abstract] [Full Text] [PDF]

Home page
 Eur Heart JHome page
F. Thuny, S. Beurtheret, J. Mancini, V. Gariboldi, J.-P. Casalta, A. Riberi, R. Giorgi, F. Gouriet, L. Tafanelli, J.-F. Avierinos, et al.
The timing of surgery influences mortality and morbidity in adults with severe complicated infective endocarditis: a propensity analysis
Eur. Heart J., March 26, 2009; (2009) ehp089v1.
[Abstract] [Full Text] [PDF]

Home page
 J. Thorac. Cardiovasc. Surg.Home page
A. M. Sheikh, A. M. Elhenawy, M. Maganti, S. Armstrong, T. E. David, and C. M. Feindel
Outcomes of surgical intervention for isolated active mitral valve endocarditis.
J. Thorac. Cardiovasc. Surg., January 1, 2009; 137(1): 110 - 116.
[Abstract] [Full Text] [PDF]

Home page
 Ann. Thorac. Surg.Home page
C. A. Mestres
Invited Commentary
Ann. Thorac. Surg., May 1, 2008; 85(5): 1569 - 1570.
[Full Text] [PDF]

This Article
Right arrow Abstract Freely available
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to Personal Folders
Right arrow Download to citation manager
Right arrow Author home page(s):
Paul Herijgers
Right arrow Permission Requests
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Hill, E. E.
Right arrow Articles by Herijgers, P.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Hill, E. E.
Right arrow Articles by Herijgers, P.
Related Collections
Right arrow Valve disease
Right arrowRelated Article

HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
ANN THORAC SURG ASIAN CARDIOVASC THORAC ANN EUR J CARDIOTHORAC SURG
J THORAC CARDIOVASC SURG ICVTS ALL CTSNet JOURNALS