Ann Thorac Surg 2007;83:1915
© 2007 The Society of Thoracic Surgeons
Key References
Mediastinal Germ Cell Tumors
Kenneth A. Kesler, MDa,*,
Lawrence H. Einhorn, MDb
a Department of Surgery, Indiana University School of Medicine, Indianapolis, Indiana
b Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana
* Address correspondence to Dr Kesler, Indiana University School of Medicine, Department of Surgery, Thoracic Division, 545 Barnhill Dr, Emerson Hall #215, Indianapolis, IN 46202 (Email: kkesler{at}iupui.edu).
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Review Papers
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- 1 Strollo D, Rosado de Christenson M, and Jett J. Primary mediastinal tumors part I. Tumors of the anterior mediastinum. Chest 1997;112:511–22.
- 2 Nichols CR. Mediastinal germ cell tumors: clinical features and biologic correlates. Chest 1991;99:472–9.
- 3 Strollo D, Rosado-de-Christenson M. Primary mediastinal malignant germ cell neoplasms: imaging features. Chest Surg Clin N Am 2002;12:645–58.
- 4 Houldsworth J. Genetics and biology of male germ cell tumors. Chest Surg Clin N Am 2002;12:629–43.
- 5 Donadio A, Bosl G. The future of therapy for nonseminomatous germ cell tumors. Chest Surg Clin N Am 2002;12:769–89.
- 6 Wood D. Mediastinal germ cell tumors. Semin Thorac Cardiovasc Surg 2000;12:278–89.
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Pathologic Spectrum and Biologic Behavior
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- 7 Moran C, Suster S. Primary germ cell tumors of the mediastinum I. Analysis of 322 cases with special emphasis on teratomatous lesions and a proposal for histopathologic classification and clinical staging. Cancer 1997;80:681–90.
- 8 Moran C, Suster S, Koss M. Primary germ cell tumors of the mediastinum III. Yolk sac tumor, embryonal carcinoma, choriocarcinoma, and combined nonteratomatous germ cell tumors of the mediastinum-a clinicopathologic and immunohistochemical study of 64 cases. Cancer 1997;80:699–707.
- 9 Moran C, Suster S, Przygodzki R, et al. Primary germ cell tumors of the mediastinum II. Mediastinal seminomas-a clinicopathologic and immunohistochemical study of 120 cases. Cancer 1997;80:691–8.
- 10 Weidner N. Germ-cell tumors of the mediastinum. Semin Diagn Pathol 1999;16:42–50.
- 11 Reuter V. The pre and post chemotherapy pathologic spectrum of germ cell tumors. Chest Surg Clin N Am 2002;12:673–94.
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Mature and Immature Teratoma
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- 12 Allen MS. Presentation and management of benign mediastinal teratomas. Chest Surg Clin N Am 2002;12:659–64.
- 13 Moeller KH, Rosado-de-Christenson ML, Templeton PA. Mediastinal mature teratoma imaging features. Am J Roetgenol 1997;169:985–90.
- 14 Allen MS. Benign mediastinal germ cell tumors in Wood DE, Thomas CR Jr, eds. Mediastinal tumors. Berlin: Springer-Verlag, 1995;37–42.
- 15 Lewis B, Hurt R, Payne W, et al. Benign teratomas of the mediastinum. J Thorac Cardiovasc Surg 1983;86:727–31.
- 16 Dulmet E, Macchiarini P, Suc B, et al. Germ cell tumors of the mediastinum: a 30 year experience. Cancer 1993;72:1894–901.
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Seminomatous Germ Cell Tumors
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- 17 Bokemeyer C, Nichols C, Droz J, et al. Extragonadal germ cell tumors of the mediastinum and retroperitoneum: results from an international analysis. J Clin Oncol 2002;20:1864–73.
- 18 Fizazi K, Culine J, Droz M, et al. Initial management of primary mediastinal seminoma: radiotherapy or cisplatin-based chemotherapy? Eur J Cancer 1998;34:347–52.
- 19 Duchesne G, Stenning S, Aass N, et al. Radiotherapy after chemotherapy for metastatic seminoma-a diminishing role. Eur J Cancer 1997;33:829–35.
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Non-Seminomatous Germ Cell Tumors
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Chemotherapy
- 20 Hinton S, Catalano P, Einhorn L, et al. Cisplatin, etoposide and either bleomycin or ifosfamide in the treatment of disseminated germ cell tumors: final analysis of an intergroup trial. Cancer 2003;97:1869–75.
- 21 Bajorin D, Nichols C, Margolin K, et al. Phase III randomized trial of conventional-dose chemotherapy with or without high-dose chemotherapy and autologous hematopoietic stem-cell rescue as first-line treatment for patients with poor-prognosis metastatic germ cell tumors. J Clin Oncol 2007;25:239–40.
- 22 Hartmann J, Einhorn L, Nichols C, et al. Second-line chemotherapy in patients with relapsed extragonadal non-seminomatous germ cell tumors: results of an international multicenter analysis. J Clin Oncol 2001;19:1641–8.
- 23 De Giorgi U, Demirer T, Wandt H, et al. Second-line high-dose chemotherapy in patients with mediastinal and retroperitoneal primary non-seminomatous germ cell tumors: the EBMT experience. Ann Oncol 2005;16:146–51.
- 24 Walsh GL, Taylor GD, Nesbitt JC, et al. Intensive chemotherapy and radical resections for primary nonseminomatous mediastinal germ cell tumors. Ann Thorac Surg 2000;69:337–43.
Surgery and Outcomes
- 25 Bokemeyer C, Nichols C, Droz J, et al. Extragonadal germ cell tumors of the mediastinum and retroperitoneum: results from an international analysis. J Clin Oncol 2002;20:1864–73.
- 26 Wright C, Kesler K. Surgical techniques and outcomes for primary nonseminomatous germ cell tumors. Chest Surg Clin N Am 2002;12:707–15.
- 27 Kesler K, Rieger K, Ganjoo K, et al. Primary mediastinal nonseminomatous germ cell tumors: the influence of postchemotherapy pathology on long-term survival after surgery. J Thorac Cardiovasc Surg 1999;18:692–700.
- 28 Vuky J, Bains M, Bacik J, et al. Role of postchemotherapy adjunctive surgery in the management of patients with nonseminoma arising from the mediastinum. J Clin Oncol 2001:19:682–8.
- 29 Fizazi K, Culine S, Droz J, et al. Primary mediastinal nonseminomatous germ cell tumors: results of modern therapy including cisplatin-based chemotherapy. J Clin Oncol 1998;16:725–32.
- 30 Goss P, Schwertfeger L, Blackstein M, et al. Extragonadal germ cell tumors: a 14-year Toronto experience. Cancer 1994;73:1971–9.
- 31 Schneider B, Kesler K, Brooks J, et al. Outcome of patients with residual germ cell or non-germ cell malignancy after resection of primary mediastinal nonseminomatous germ cell cancer. J Clin Oncol 2004;2:1195–200.
- 32 Andrade R, Kesler K, Wilson J, et al. Short and long-term outcomes after large pulmonary resection for germ cell tumors following bleomycin-combination chemotherapy. Ann Thorac Surg 2004;78:1224–9.
- 33 Afifi H, Bosl G, Burt M. Mediastinal growing teratoma syndrome. Ann Thorac Surg 1997;64:359–62.
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Review Papers
Pathologic Spectrum and Biologic...