ATS
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Add to Personal Folders
Right arrow Download to citation manager
Right arrow Author home page(s):
Jason A. Williams
William A. Baumgartner
Right arrow Permission Requests
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Williams, J. A.
Right arrow Articles by Baumgartner, W. A.
Right arrow Search for Related Content
PubMed
Right arrow Articles by Williams, J. A.
Right arrow Articles by Baumgartner, W. A.
Related Collections
Right arrowRelated Article

Ann Thorac Surg 2007;83:725-726
© 2007 The Society of Thoracic Surgeons

Correspondence

Reply

Jason A. Williams, MD, William A. Baumgartner, MD

Division of Cardiac Surgery, The Johns Hopkins Hospital, 600 North Wolfe St, Blalock 618, Baltimore, MD 21287

(Email: wbaumgar{at}csurg.jhmi.jhu.edu).

To the Editor:

We would like to thank Drs Veinot and Ruel [1] for bringing up the issue of valproic acid as a cause of increased surgical bleeding. We are aware of this potential complication and appreciate their comments.

In our canine model, we did not see any significant bleeding [2]. However, clearly when we develop a safety trial for this drug and cardiopulmonary bypass, we will list this as one of the potential complicating factors in our informed consent. We also plan to ask our hematology colleagues as to whether there is a better hematology screening method when this drug is given immediately prior to operation. As the authors point out, it is unclear whether this potential bleeding complication is dose related or if it is idiosyncratic.

Once again we appreciate the authors’ comments.


   References
Top
 References
 

  1. Veinot JP, Ruel M. Valproic acid and bleeding: Caution required (letter) Ann Thorac Surg 2007;83:725.[Free Full Text]
  2. Williams JA, Barreiro CJ, Nwakanma LU, et al. Valproic acid prevents brain injury in a canine model of hypothermic circulatory arrest: a promising new approach to neuroprotection during cardiac surgery Ann Thorac Surg 2006;81:2235-2242.[Abstract/Free Full Text]

Related Article

Valproic Acid and Bleeding: Caution Required
John P. Veinot and Marc Ruel
Ann. Thorac. Surg. 2007 83: 725. [Extract] [Full Text] [PDF]




This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Add to Personal Folders
Right arrow Download to citation manager
Right arrow Author home page(s):
Jason A. Williams
William A. Baumgartner
Right arrow Permission Requests
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Williams, J. A.
Right arrow Articles by Baumgartner, W. A.
Right arrow Search for Related Content
PubMed
Right arrow Articles by Williams, J. A.
Right arrow Articles by Baumgartner, W. A.
Related Collections
Right arrowRelated Article

HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
ANN THORAC SURG ASIAN CARDIOVASC THORAC ANN EUR J CARDIOTHORAC SURG
J THORAC CARDIOVASC SURG ICVTS ALL CTSNet JOURNALS