ATS
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to Personal Folders
Right arrow Download to citation manager
Right arrow Author home page(s):
Tomas Vanek
Zbynek Straka
Right arrow Permission Requests
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Vanek, T.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Vanek, T.
Related Collections
Right arrow Coronary disease
Right arrowRelated Article

Ann Thorac Surg 2006;82:1950-1951
© 2006 The Society of Thoracic Surgeons

Correspondence

Aprotinin Reduces Troponin I Levels in OPCABG

Tomas Vanek, MD, PhD, Martin Jares, MD, Zbynek Straka, MD, PhD, MSM0021620817 Study Group

Department of Cardiac Surgery, 3rd Medical School of Charles University, Srobarova 50, 100 34 Prague 10, Czech Republic

(Email: vanek{at}fnkv.cz).

To the Editor:

We congratulate Poston and colleagues [1] on their interesting article dispelling a little of the concerns or fears of an increase in graft failure in off-pump coronary artery bypass grafting (OPCABG) when aprotinin is used to reduce blood loss. Last year we published the results of a prospective, randomized, double-blind study comparing hemostatic effects of tranexamic acid versus aprotinin versus placebo in OPCABG [2]. In addition, and for safety evaluation reasons, the time course of myocardial enzymes in the very early postoperative period was assessed. We found no statistically significant intergroup differences at any time (preoperatively, 8 hours, and 24 hours postoperatively) within the time course of creatine phosphokinase (CK) levels, isoenzyme MB (CK-MB) levels and the relative index of CK-MB and CK, but troponin I levels differed between our study groups 8 hours postoperatively (p = 0.015) (Table 1).


View this table:
[in this window]
[in a new window]
  		Table 1. Time Course of Troponin I Levels (µg/L) in Off-Pump Coronary Artery Bypass Grafting a
 
Post hoc tests showed above all the most significant difference between the aprotinin treated group and the placebo group (p < 0.001) due to the lowest mean values of troponin I in the aprotinin group. Twenty-four hours postoperatively the mean levels of troponin I remained lowest in the aprotinin treated group and highest in the placebo group, but these differences were already without statistical significance. We assume that our findings concerning the time course of troponin I levels support the conclusions of Poston and colleagues [1] that aprotinin shows not only hemostatic, but also antithrombotic (and probably vein graft endothelium preservation) mechanism during OPCABG.


   References
Top
 References
 

  1. Poston RS, White Ch, Gu J, et al. Aprotinin shows both hemostatic and antithrombotic effects during off-pump coronary artery bypass grafting Ann Thorac Surg 2006;81:104-111.[Abstract/Free Full Text]
  2. Vanek T, Jares M, Fajt R, et al. Fibrinolytic inhibitors in off-pump coronary surgery: a prospective, randomized, double-blind TAP study (tranexamic acid, aprotinin, placebo) Eur J Cardio-thorac Surg 2005;28:563-568.[Abstract/Free Full Text]

Related Article

Reply
Robert Poston and Ozeki Toshinaga
Ann. Thorac. Surg. 2006 82: 1951-1952. [Extract] [Full Text] [PDF]



This article has been cited by other articles:


Home page
 Ann. Thorac. Surg.Home page
R. Poston and O. Toshinaga
Reply
Ann. Thorac. Surg., November 1, 2006; 82(5): 1951 - 1952.
[Full Text] [PDF]

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to Personal Folders
Right arrow Download to citation manager
Right arrow Author home page(s):
Tomas Vanek
Zbynek Straka
Right arrow Permission Requests
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Vanek, T.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Vanek, T.
Related Collections
Right arrow Coronary disease
Right arrowRelated Article

HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
ANN THORAC SURG ASIAN CARDIOVASC THORAC ANN EUR J CARDIOTHORAC SURG
J THORAC CARDIOVASC SURG ICVTS ALL CTSNet JOURNALS