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Ann Thorac Surg 2005;79:1467
© 2005 The Society of Thoracic Surgeons

Correspondence

Creatine Kinase

Michelle Petrou, MBBS

Faculty of Clinical Sciences, Royal Free and University College London London, WC1E 6BT, UK

Marialena Gregoriades, MRCP, Vassilios Vassiliou, MBBS

Department of Renal Medicine, Middlesex Hospital, University College London Hospitals, London, W1N 8AA, UK

(E-mail: vassiliou{at}doctors.org.uk).

To the Editor:

We noticed in the article by Palatianos and colleagues [1] that the authors used the term creatinine kinase to refer to an enzyme used as a marker of myocardial damage. We believe they actually were referring to the enzyme creatine kinase. Creatine kinase catalyzes the reversible phosphorylation of creatine to phosphorylcreatine and is indeed a marker of cardiac injury. On the contrary, the conversion of creatinine requires no enzymatic input, and the enzyme creatinine kinase does not exist.

Use of the incorrect expression creatinine kinase has grown in recent years, and to assess this rise, we performed a MEDLINE search on June 6, 2004, using the term creatinine kinase. The results showed a significant and steady increase (Table 1). We take this opportunity to bring to the attention of readers and others authors the fact that use of the term creatinine kinase is incorrect.


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  		Table 1. Entries for "Creatinine Kinase" in Last Four Decades
 


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  1. Palatianos GM, Balentine G, Papadakis EG, et al. Neutrophil depletion reduces myocardial reperfusion morbidity Ann Thorac Surg 2004;77:956-961.[Abstract/Free Full Text]




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