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Ann Thorac Surg 2005;79:1096
© 2005 The Society of Thoracic Surgeons

Correspondence

Markers of Endothelial Activation During Cardiopulmonary Bypass: Reply

Vibeke Videm, MD, PhD

Department of Immunology and Transfusion Medicine, St. Olav's Hospital, N-7006 Trondheim, Norway

(E-mail: vibeke.videm{at}ntnu.no).

To the Editor:

My coauthors and I thank Dr Misawa for his interesting comments. Clearly, not every substance released from endothelial cells on activation is useful as a clinical marker in relation to cardiopulmonary bypass. Furthermore, there are still many gaps in our current knowledge about endothelial markers. More research is warranted on the relationship between surface-bound and soluble endothelial markers, the trapping of these substances in the extracorporeal circuit, and marker degradation and half-life. If our ultimate goal is to use markers of endothelial activation to predict postoperative organ damage and try to intervene early, any candidate marker must also prove its relationship to clinical outcome in a sufficiently large study.


Related Article

Markers of Endothelial Activation During Cardiopulmonary Bypass
Yoshio Misawa
Ann. Thorac. Surg. 2005 79: 1096. [Extract] [Full Text] [PDF]




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