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Ann Thorac Surg 2004;77:729-730
© 2004 The Society of Thoracic Surgeons


How to do it

Posterior mitral valve restoration for ischemic regurgitation

Pino Fundarò, MDa*, Marco Pocar, MD, PhDa, Andrea Moneta, MDa, Francesco Donatelli, MDa, Adalberto Grossi, MDa

a Divisione e Cattedra di Cardiochirurgia, IRCCS Ospedale Maggiore e Università degli Studi di Milano, Milan, Italy

Accepted for publication April 14, 2003.

* Address reprint requests to Dr Fundarò, Corso Vercelli, 35, 20144, Milan, Italy
e-mail: pinofundaro{at}yahoo.it


    Abstract
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 Abstract
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Chronic ischemic mitral regurgitation is traditionally a complex lesion to repair. Only restrictive annuloplasty has become an accepted strategy to avoid valve replacement, but results are unsatisfactory in some subgroups of patients. We describe an original technique that addresses the pathophysiologic mechanisms responsible for one of the most common subtypes of ischemic mitral regurgitation, ie, asymmetric tethering of the mitral leaflets after inferior myocardial infarction. The technique includes partial detachment of the posterior leaflet from the mitral annulus, annular plication, and posterior cusp plasty.


    Introduction
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Chronic ischemic mitral regurgitation (IMR) is a functional disorder secondary to postinfarction left ventricular (LV) remodeling. Among the pathophysiologic mechanisms encompassed by IMR, two are prevalent: asymmetric apical displacement of the posterior papillary muscle in case of previous inferior myocardial infarction (MI) and global LV dilation with tethering of both leaflets toward the LV apex, generally following extensive anteroseptal MI.

Since November 2000, the technique described has been performed in 9 patients and mainly addresses the first pathophysiologic mechanism attempting to correct posterior leaflet tethering.


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The operation is performed through a median sternotomy on cardiopulmonary bypass with bicaval and aortic cannulation. Antegrade and retrograde cold blood cardioplegic arrest is routinely employed at our Institution.

The mitral valve is approached through a standard left atriotomy. Three stay sutures are first placed in the mitral annulus, at the two commissures and at the posterior leaflet midpoint, to optimize exposure and allow accurate valve assessment. By definition, no structural lesions of the leaflets and chordae are present in pure IMR. A scarred atrophic posterior papillary muscle may be observed (3 out of 9 patients, in our experience). Posterior annular dilation of varying degree is usually present. The portion of the posterior mitral leaflet attached to the postero-medial papillary muscle appears stretched toward the LV apex and may be difficult to mobilize. An incision is performed to detach the tethered segment of the posterior leaflet from the mitral annulus and extended to include the central portion of the posterior leaflet (Figure 1A, B). The secondary chordae are transected to increase posterior leaflet mobility, whereas basal chordae are preserved to avoid weakening of the atrio-ventricular junction. The detached portion of the mitral annulus is plicated with interrupted sutures and the resulting defect in the posterior leaflet closed with a running suture (Figure 1C). It should be noticed that, as a consequence of the adjacent plication, the defect at the base of the posterior leaflet is oriented in a radial direction. The plicated annulus is reinforced with a short Gore-Tex strip or posterior annuloplasty band (Figure 1D). Transesophageal echocardiography is routinely performed after discontinuation of cardiopulmonary bypass and showed mild or no regurgitation in all patients.



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Fig 1. (A) Incision line at the base of the posterior mitral leaflet. (B) Detached posterior leaflet everted anteriorly. (C) Annular plication with interrupted sutures and resulting defect at the leaflet's base. (D) Defect closed with a running suture and reinforcement of the plicated annulus. Notice how x and y are initially situated near the midpoint of the incision (B), but correspond to the ends of the plicated tissues after the surgical reconstruction (C).

 

    Comment
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 Comment
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Traditionally, chronic IMR is a complex lesion to repair and valve replacement is still widely performed to treat this condition. IMR is related to displacement of one or both papillary muscles and/or mitral annular dilation. Leaflet tethering usually prevails in the posterior portion and results in asymmetric and restricted motion of the posterior mitral leaflet during systole and anterior leaflet "pseudoprolapse" [1, 2]. Although not unvariably atrophied, the posterior papillary muscle is generally displaced toward the apex at echocardiography in patients with post-MI regional LV inferior wall dyskinesia or extensive akinesia [1].

Current conservative surgical approaches to IMR mainly focus on annular reduction, with or without implantation of a prosthetic ring [36]. However, because persisting regurgitation of varying degree is frequently observed with annuloplasty alone, a more sophisticated surgical approach to IMR appears indicated [2, 7].

In this respect, a strictly anatomic correction would imply surgical restoration of LV geometry to abolish functional IMR. It has been stated that the most important goal in repairing the valve is to reduce and fix the mitral annular dimension in the antero–posterior (septal–lateral in anatomic terms) axis [2, 8], which may be obtained by implanting stiffer rings [3]. However, these impair or completely abolish annular dynamic motion, which appears important for better preservation of LV function, especially in patients with ischemic cardiomyopathy [4].

In conclusion the procedure has been developed to restore a normal distance between the mitral valve attachments, ie, the annulus and papillary muscle tip, and modifies the anatomy at the valvular level to correct a functional disorder produced primarily by a LV lesion. More specifically, annular geometry is restored with a near-to-normal ratio between the antero–posterior and intercommissural diameters (3:4, according to Carpentier). Plication reduces the circumference of the posterior annulus and "repositions" the tethered portion of the mitral valve more anteriorly. The posterior leaflet is extended on the antero–posterior axis and reduced on the intercommissural axis, allowing better coaptation in the segment adjacent to annular plication. Finally, no occurrence of systolic anterior motion was observed. Further investigation and follow-up are warranted to validate preliminary results.


    References
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 Abstract
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 Technique
 Comment
 References
 

  1. Kumanohoso T., Otsuji Y., Yoshifuku S., et al. Mechanism of higher incidence of ischemic mitral regurgitation in patients with inferior myocardial infarction: quantitative analysis of left ventricular and mitral valve geometry in 103 patients with prior myocardial infarction. J Thorac Cardiovasc Surg 2003;125:135-143.[Abstract/Free Full Text]
  2. Miller D.C. Ischemic mitral regurgitation redux—To repair or to replace?. J Thorac Cardiovasc Surg 2001;122:1059-1062.[Free Full Text]
  3. Bolling S.F., Pagani F.D., Deeb G.M., Bach D.S. Intermediate-term outcome of mitral reconstruction in cardiomyopathy. J Thorac Cardiovasc Surg 1998;115:381-388.[Abstract/Free Full Text]
  4. Radovanovic N., Mihajlovic B., Selestiansky J., et al. Reductive annuloplasty of double orifices in patients with primary dilated cardiomyopathy. Ann Thorac Surg 2002;73:751-755.[Abstract/Free Full Text]
  5. Grossi E.A., Goldberg J.D., LaPietra A., et al. Ischemic mitral valve reconstruction and replacement: comparison of long-term survival and complications. J Thorac Cardiovasc Surg 2001;122:1107-1124.[Abstract/Free Full Text]
  6. Gillinov A.M., Wierup P.N., Blackstone E.H., et al. Is repair preferable to replacement for ischemic mitral regurgitation?. J Thorac Cardiovasc Surg 2001;122:1125-1141.[Abstract/Free Full Text]
  7. Messas E., Guerrero J.L., Handschumacher M.D., et al. Chordal cutting. A new therapeutic approach for ischemic mitral regurgitation. Circulation 2001;104:1958-1963.[Abstract/Free Full Text]
  8. Timek T.A., Lai D.T., Tibayan F., et al. Septal-lateral annular cinching abolishes acute ischemic mitral regurgitation. J Thorac Cardiovasc Surg 2002;23:881-888.



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This Article
Right arrow Abstract Freely available
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
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Right arrow Citation Map
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Right arrow Add to Personal Folders
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Right arrow Author home page(s):
Pino Fundarò
Marco Pocar
Andrea Moneta
Francesco Donatelli
Adalberto Grossi
Right arrow Permission Requests
Citing Articles
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Right arrow Articles by Fundarò, P.
Right arrow Articles by Grossi, A.
Right arrow Search for Related Content
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Right arrow PubMed Citation
Right arrow Articles by Fundarò, P.
Right arrow Articles by Grossi, A.
Related Collections
Right arrow Valve disease


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