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Ann Thorac Surg 2002;73:S366
© 2002 The Society of Thoracic Surgeons

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SUPPLEMENT: OUTCOMES 2001: SCIENTIFIC ABSTRACTS

Neurological outcome and S100 after coronary artery bypass grafting and abdominal aortic surgery

^a Department of Anaesthetics, Royal Infirmary of Edinburgh, Edinburgh, United Kingdom

Introduction. This pilot study aimed to compare short-term neurological outcome and levels of S100ß in the jugular bulb (S100) between patients undergoing coronary artery bypass grafting (CABG) [n = 40] and abdominal aortic (AA) [n = 7] surgery and to determine whether they could be predicted by demographic or perioperative factors.

Methods. The study was approved by the institution’s ethics committee and patients gave informed consent. Paired jugular bulb and arterial blood samples were aspirated 6 hours after surgery. A scored neurological examination (NS) was performed before and 7 days after surgery. Predictor variables that correlated (p < 0.05) with the postoperative NS or S100 were entered as covariates along with operation type as a factor, into general factorial analysis of variance models.

Results. There was no difference in postoperative NS (p = 0.32) or S100 (p = 0.40) between the surgical groups. S100 did not correlate with postoperative NS (r = -0.03, p = 0.85). Preoperative NS (r = 0.89) and jugular bulb oxygen tension (PjO₂)(r = 0.42) correlated with postoperative NS (p < 0.01). Age (r = 0.55), body surface area (r = -0.57), and jugular bulb saturation (SjO₂) (r = -0.72) correlated with S100 (p < 0.05).

Conclusions. The study is too small to exclude true differences in NS or S100 between the surgical groups Why PjO₂, but not SjO₂, predicts short-term neurological outcome requires further investigation. After surgery, S100 appears to be influenced not only by age but also cerebral perfusion and, possibly, pump flow rate during cardiopulmonary bypass.

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Alert me to new issues of the journal Add to Personal Folders Download to citation manager Permission Requests Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Alston, R.P. Articles by Millar, S.M. Search for Related Content PubMed Articles by Alston, R.P. Articles by Millar, S.M. Related Collections Coronary disease