ATS
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Abstract Freely available
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to Personal Folders
Right arrow Download to citation manager
Right arrow Author home page(s):
Nobuyoshi Shimizu
Right arrow Permission Requests
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Nagahiro, I.
Right arrow Articles by Shimizu, N.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Nagahiro, I.
Right arrow Articles by Shimizu, N.
Related Collections
Right arrow Lung - other

Ann Thorac Surg 2001;72:362-365
© 2001 The Society of Thoracic Surgeons

Original article: general thoracic

Pulmonary function, postoperative pain, and serum cytokine level after lobectomy: a comparison of VATS and conventional procedure

Itaru Nagahiro, MDa, Akio Andou, MDa, Motoi Aoe, MDa, Yoshifumi Sano, MDa, Hiroshi Date, MDa, Nobuyoshi Shimizu, MDa

a Department of Surgery II, Okayama University Medical School, Okayama, Japan

Accepted for publication May 1, 2001.

Address reprint requests to Dr Nagahiro, Department of Surgery II, Okayama University Medical School, 2-5-1 Shikata-cho, Okayama 700-8558, Japan
e-mail: nagahiro{at}nigeka2.hospital.okayama-u.ac.jp


   Abstract
Top
 Abstract
Introduction
 Patients and methods
 Results
 Comment
 Acknowledgments
 References
 
Background. Although lobectomy by the video-assisted thoracic surgical (VATS) approach is assumed to be less invasive than lobectomy by the standard posterolateral thoracotomy (PLT) approach, it has not been scientifically proven.

Methods. Twenty-two consecutive, nonrandomized patients, underwent either a VATS approach (n = 13) or a posterolateral thoracotomy approach (n = 9) to perform pulmonary lobectomy for peripheral lung cancers in clinical stage I. Pain and serum cytokines were measured until postoperative day (POD) 14. Pulmonary function tests were performed on POD 7 and POD 14.

Results. Postoperative pain was significantly less in the VATS group on PODs 0, 1, 7, and 14. Recovery of pulmonary function was statistically better in the VATS group. Negative correlations between the recovery rates of pulmonary function and postoperative pain were observed on POD 7. The serum interleukin-6 level in the PLT group was significantly elevated on POD 0 compared with the VATS group (posterolateral thoracotomy: 21.6 ± 24.3 pg/mL; VATS: 4.1 ± 7.9 pg/mL, p = 0.03).

Conclusions. Lobectomy by the VATS approach generates less pain and cytokine production, and preserves better pulmonary function in the early postoperative phase.


   Introduction
Top
 Abstract
 Introduction
Patients and methods
 Results
 Comment
 Acknowledgments
 References
 
Lobectomy by the video-assisted thoracic surgical (VATS) approach is a well-established and widespread therapeutic method for treating small peripheral lung cancer [1–3]. In the past few years, the VATS procedure has been perceived to be less invasive than the conventional open thoracotomy with respect to less pain, better preservation of pulmonary function, and less impairment of the shoulder girdle [4–6]. Although there is a consensus on the benefits of the VATS procedure in general, few studies have looked at the procedure when used for lobectomy.

It is known that patients with surgical injury or infection exhibit alterations in hemodynamic, metabolic, and immune responses that are largely orchestrated by endogenous mediators referred to as cytokines [7]. Elective surgery provokes an increase in the circulating cytokine levels, especially with regard to interleukin (IL)-6, and the magnitude of the elevation is related directly to the degree of tissue injury [8]. Few studies have investigated cytokine production when comparing VATS lobectomy with conventional lobectomy.

The purpose of this study was to estimate and compare the operative stress of the VATS lobectomy and standard lobectomy through posterolateral thoracotomy (PLT), and to investigate the hypothesis that the VATS lobectomy is less invasive than the conventional PLT lobectomy.


   Patients and methods
Top
 Abstract
 Introduction
 Patients and methods
Results
 Comment
 Acknowledgments
 References
 
Patient cohorts
A series of 22 consecutive patients requiring single lobectomy for clinical stage I peripheral lung cancer between June 1999 and April 2000 were included in the study. A signed and written, informed consent was obtained from each patient, and the study was approved by the Okayama University Medical School Review Board, Okayama, Japan.

Thirteen patients whose peripheral lung cancer had a maximum diameter less than or equal to 3 cm (T1) and no hilar or mediastinal lymph node swelling (N0) on chest computed tomographic scan were operated on by VATS lobectomy. The maximum tumor dimension was more significant in predicting mediastinal lymph node metastasis than the lymph node size on computed tomographic scan [9]. At our institution, patients whose lung cancer had a diameter greater than 3 cm (T2), regardless of mediastinal lymph node status on computed tomographic scan, were normally recommended to undergo mediastinoscopy and preoperative chemoradiotherapy before lobectomy when biopsy revealed positive nodes for cancer cells. In the present study, 9 patients with peripheral lung cancer staged as T2 N0 chose not to undergo mediastinoscopy and preoperative chemoradiotherapy. There has been controversy over the adequacy of mediastinal lymph node dissection by VATS. Therefore, to accomplish more complete mediastinal lymph node dissection, conventional lobectomy with mediastinal lymph node dissection through posterolateral thoracotomy was used to treat T2 N0 disease instead of VATS lobectomy in the 9 patients, and they served as the control group.

In the VATS lobectomy, a 7-cm long skin incision was made at the fourth intercostal space in the anterior axillary line as a minithoracotomy. Two other 2- to 3-cm long incisions for ports were made at the sixth intercostal space in the posterior axillary line and at the seventh intercostal space in the midaxillary line. No ribs were resected. A metal chest retractor was not used in the minithoracotomy, but instead, a silicon rubber instrument usually used in laparoscopic surgery (Lap Protector, Hakko Co, Ltd, Tokyo, Japan) was applied to open the wound and prevent chest wall closure. In the conventional PLT approach, an incision approximately 20-cm long was made, the latissimus dorsi muscle and the serratus anterior muscle were divided, and a thoracotomy was performed at the fourth or fifth intercostal space. One or two ribs adjacent to the thoracotomy were resected at the posterior segment. A metal chest retractor was used to open the wound and spread the intercostal space.

All patients in both groups received epidural tube insertion just before the operation, and were then intubated with a double lumen tracheal tube for anesthesia. All patients received epidural administration of 0.125% bupivacaine during the operations. Continuous epidural infusion of 0.125% bupivacaine (4 mL/hr) was used postoperatively until chest drainage tubes were removed. Diclofenac suppository was predominantly used for postoperative pain control in addition to the epidural anesthesia, and intramuscular administration of pentazocine was used if the pain was uncontrollable by suppository.

Measurements
Pain was quantitated by an 11-point pain scale (0 = no pain, 10 = maximal imaginable pain) [10] on PODs 0, 1, 2, 4, 7, and 14. Blood samples were drawn preoperatively and on the same PODs as the pain measurement, centrifuged at 3000 G for 5 minutes, and then stored in deep refrigeration at –70°C until serum cytokines measurements were performed. Serum cytokines consisting of IL-6, -8, -10, and tumor necrosis factor-{alpha} (TNF-{alpha}) were measured using ELISA. Chest tubes were removed by POD 7 in all patients, and pulmonary function tests were performed in the usual manner on PODs 7 and 14 by portable spirometer (Autospiro AS-303, Minato Medical Science Co Ltd, Osaka, Japan). Recovery rates of forced vital capacity (FVC), vital capacity, and forced expiratory volume in one second (FEV1) were expressed by the percent of predicted values that were calculated by numbers of resected pulmonary segments: Predicted value (mL) = preoperative value (mL) x (19 - the number of resected segment)/19. The number of segments in each lobe was defined as follows: right upper lobe: 3, right middle lobe: 2, right lower lobe: 5, left upper lobe: 5, left lower lobe: 4.

Statistics
The {chi}2 test, Mann-Whitney U test, and Student’s t test were used to compare the characteristics of both groups and paired data. Analysis of variance was used for continuous data. Probability of less than 0.05 was considered significant. All data were expressed as mean ± the standard deviation of the mean.


   Results
Top
 Abstract
 Introduction
 Patients and methods
 Results
Comment
 Acknowledgments
 References
 
Patient characteristics and anatomic distribution of the primary lung cancers (ie, lobectomies performed) are shown in Tables 1 and 2. Gender, age, histologic type of tumor, operation time, amount of intraoperative bleeding, duration of chest drainage, duration of epidural anesthesia, pulmonary function, and method of lobectomy performed were not different between the groups. All tumors in the VATS group were pathologic stage I, but one tumor was stage II for hilar lymph node metastasis, and two tumors were stage IIIA for mediastinal lymph node metastasis in the PLT group.


View this table:
[in this window]
[in a new window]
  		Table 1. Characteristics of the VATS Lobectomy and Standard Lobectomy Groups

 

View this table:
[in this window]
[in a new window]
  		Table 2. Anatomic Distribution of the Primary Lung Cancers and Lobectomies Performed

 
The amounts of postoperative analgesics (except for epidural administration) used by POD 14 were compared, and the patients in the PLT group needed significantly larger amounts of analgesics postoperatively (Diclofenac suppository; PLT: 406 ± 212 mg, VATS: 202 ± 238 mg, p = 0.034, Pentazocine; PLT: 13.1 ± 16.9 mg, VATS: 1.4 ± 4.5 mg, p = 0.042). The postoperative pain measurements in the VATS group were significantly less than in the PLT group (Fig 1). Serum IL-6 level, a pro-inflammatory cytokine, was significantly higher in the PLT group on POD 0 than in the VATS group (Fig 2). Other serum cytokine levels did not differ between the groups during the postoperative period. When the correlation between pain and serum cytokine level was examined in all cases, a significant correlation was observed in IL-10 levels (r = 0.245, p = 0.003). The recovery rates of FVC, FEV1, and vital capacity were significantly better and faster in the VATS group (FVC on POD7: PLT 71.4% ± 15.8% vs VATS 87.4% ± 11.7%, p = 0.011; FVC on POD14: PLT 76.5% ± 15.6% vs VATS 97.3% ± 13.8%, p = 0.005; FEV1 on POD14: PLT 80.6% ± 13.7% vs VATS 95.4% ± 15.7%, p = 0.039; vital capacity on POD7: PLT 67.7% ± 21.8% vs VATS 86.8% ± 13.6%, p = 0.019). When the correlation between pain and pulmonary function was examined in all cases, a significant correlation was observed on POD 7 (Fig 3). However, the correlation no longer existed on POD 14.



View larger version (14K):
[in this window]
[in a new window]
  		Fig 1. Operative approach for lobectomy and postoperative pain measured by eleven-point pain scale. Data are shown as mean ± standard deviation of the mean. *p less than 0.05; **p less than 0.01. (POD = postoperative day; VATS = video-assisted thoracic surgery.)

 


View larger version (16K):
[in this window]
[in a new window]
  		Fig 2. Operative approach for lobectomy and interleukin-6 levels. Data are shown as mean ± standard deviation of the mean. (IL-6 = interleukin-6; POD = postoperative day; VATS = video-assisted thoracic surgery.)

 


View larger version (21K):
[in this window]
[in a new window]
  		Fig 3. Correlation between postoperative pain and pulmonary function recovery rate. Pain was measured by an 11-point pain scale. (FEV1.0 = forced expiratory volume in one second; FVC = forced vital capacity; VATS = video-assisted thoracic surgery; VC = vital capacity.)

 

   Comment
Top
 Abstract
 Introduction
 Patients and methods
 Results
 Comment
Acknowledgments
 References
 
As we expected, postoperative pain and recovery of pulmonary function were both superior in the VATS group for 2 weeks postoperatively in this study. Giudicelli and colleagues [11] compared lobectomy by the VATS approach and muscle-sparing thoracotomy without rib resection, and they found that there was no difference in FVC and FEV1 between the groups, and the difference in pain lasted for only 4 days postoperatively. In the present study, one or two ribs were resected posteriorly and a metal chest retractor was used to spread the intercostal space in the PLT group, while no ribs were resected and no rib spread technique was used in the VATS group. This may have enhanced the differences between the groups, resulting in a long-lasting difference in pain and a more obvious difference in pulmonary function. This may indicate the benefits of both the VATS procedure and muscle-sparing thoracotomy because these muscles and ribs are preserved.

An interesting finding in this study was the correlation between pain and pulmonary function recovery. The correlation was easily anticipated; however, it existed only in the early postoperative phase and disappeared after a week. This might indicate that adequate analgesia is necessary to reach sufficient pulmonary function recovery in the first postoperative week. To elicit better pulmonary function recovery in the early postoperative period, VATS lobectomy is advantageous because of the decreased postoperative pain. On the other hand, although the differences between the groups in postoperative pain, FVC, and FEV1 still remained on POD 14, the correlation between pain and pulmonary function no longer existed in this study. These differences in pulmonary function on POD 14 would have been caused mainly by the impairment of respiratory muscles, including serratus anterior, latissimus dorsi, and rib cage in the PLT group, not by the pain.

The IL-6 response to injury was uniquely consistent and was also related to the magnitude of the insult [8]. In the present study, the IL-6 levels in the PLT group on POD 0 were significantly higher than in the VATS group. This objectively supports the hypothesis that the operative insults of the VATS lobectomy are less than the PLT lobectomy. In addition, serum IL-10 level and postoperative pain had a significant correlation in this study. The correlation between pain and cytokines was also recently studied. A number of cytokines are released from a variety of immune cells and can induce powerful hyperalgesia [12]. Although, so far, there is no evidence that cytokines directly affect the excitability of sensory fibers, it is clear that messages can be relayed to the brain through activation of vagal afferents, and cutaneous nerves can be activated by cytokines [13]. Whether these afferent pathways will create hyperalgesia through common central neurocircuitries and neurochemistries remains to be explained.

It is important that a patient who has undergone pulmonary resection coughs vigorously to discharge more sputum in the early postoperative phase. This is advantageous in avoiding postoperative pneumonia, which is sometimes fatal for elderly patients or patients with poor pulmonary function. In this respect, the VATS lobectomy is advantageous for such patients with respect to minimizing postoperative pain and increasing preservation of pulmonary function in the early postoperative phase. Although lobectomy by the VATS procedure has been controversial because the adequacy of cancer excision by VATS has been questioned [14], some reports have shown that the survival of patients undergoing VATS lobectomy with mediastinal lymph node dissection was comparable to or better than the survival expected for lung cancer patients undergoing thoracotomy [1–3]. Therefore, the VATS lobectomy would be a better choice for high-risk patients with small peripheral lung cancer.


   Acknowledgments
Top
 Abstract
 Introduction
 Patients and methods
 Results
 Comment
 Acknowledgments
References
 
We are indebted to Satsuki Kametaka and the resident surgeons in our department for their conscientious contribution to this study. We also thank Dawn Schuessler for secretarial support.


   References
Top
 Abstract
 Introduction
 Patients and methods
 Results
 Comment
 Acknowledgments
 References
 

  1. Lewis R.J., Caccavale R.J., Bocage J.P., Widmann M.D. Video-assisted thoracic surgical non-rib spreading simultaneously stapled lobectomy. Chest 1999;116:1119-1124.[Abstract/Free Full Text]
  2. McKenna R.J., Wolf R.K., Brenner M., Fischel R.J., Wurnig P. Is lobectomy by video-assisted thoracic surgery an adequate cancer operation?. Ann Thorac Surg 1998;66:1903-1908.[Abstract/Free Full Text]
  3. Kaseda S., Aoki T., Hangai N., Shimizu K. Better pulmonary function and prognosis with video-assisted thoracic surgery than with thoracotomy. Ann Thorac Surg 2000;70:1644-1646.[Abstract/Free Full Text]
  4. Landreneau R.J., Hazelrigg S.R., Mack M.J., et al. Postoperative pain-related morbidity: video-assisted thoracic surgery versus thoracotomy. Ann Thorac Surg 1993;56:1285-1289.[Abstract]
  5. Tschernko E.M., Hofer S., Bieglmayer C., Wisser W., Haider W. Early postoperative stress. Video-assisted wedge resection/lobectomy vs conventional axillary thoracotomy. Chest 1996;109:1636-1642.[Abstract/Free Full Text]
  6. Demmy T., Curtis J. Minimally invasive lobectomy directed toward frail and high-risk patients: a case-control study. Ann Thorac Surg 1999;68:194-200.[Abstract/Free Full Text]
  7. Lin E., Calvano S.E., Lowry S.F. Inflammatory cytokines and cell response in surgery. Surgery 2000;127:117-126.[Medline]
  8. Biffl W.L., Moore E.E., Moore F.A., Peterson V.M. Interleukin-6 in the injured patient. Marker of injury or mediator of inflammation?. Ann Surg 1996;224:647-664.[Medline]
  9. Takamochi K., Nagai K., Suzuki K., Yoshida J., Ohde Y., Nishiwaki Y. Clinical predictors of N2 disease in non-small cell lung cancer. Chest 2000;117:1577-1582.[Abstract/Free Full Text]
  10. Deloach L.J., Higgins M.S., Caplan A.B., Stiff J.L. The visual analog scale in the immediate postoperative period: intrasubject variability and correlation with a numeric scale. Anesth Analg 1998;86:102-106.[Abstract]
  11. Giudicelli R., Thomas P., Lonjon T., et al. Video-assisted minithoracotomy versus muscle-sparing thoracotomy for performing lobectomy. Ann Thorac Surg 1994;58:712-718.[Abstract]
  12. Dray A. Inflammatory mediators of pain. Br J Anaesth 1995;75:125-131.[Abstract/Free Full Text]
  13. Watkins L.R., Maier S.F., Goehler L.E. Immune activation: the role of pro-inflammatory cytokines in inflammation, illness responses and pathological pain states. Pain 1995;63:289-302.[Medline]
  14. Kirby T.J., Mack M.J., Landreneau R.J., Rice T.W. Lobectomy; video-assisted thoracic surgery versus muscle sparing thoracotomy. J Thorac Cardiovasc Surg 1995;109:997-1002.[Abstract]



This article has been cited by other articles:


Home page
 J. Thorac. Cardiovasc. Surg.Home page
N. R. Villamizar, M. D. Darrabie, W. R. Burfeind, R. P. Petersen, M. W. Onaitis, E. Toloza, D. H. Harpole, and T. A. D'Amico
Thoracoscopic lobectomy is associated with lower morbidity compared with thoracotomy.
J. Thorac. Cardiovasc. Surg., August 1, 2009; 138(2): 419 - 425.
[Abstract] [Full Text] [PDF]

Home page
 Asian Cardiovasc. Thorac. Ann.Home page
C. S. Ng, I. Y. Wan, and A. P. Yim
Impact of Video-Assisted Thoracoscopic Major Lung Resection on Immune Function
Asian Cardiovasc Thorac Ann, August 1, 2009; 17(4): 426 - 432.
[Abstract] [Full Text] [PDF]

Home page
 ICVTSHome page
H. Igai, M. Takahashi, K. Ohata, A. Yamashina, T. Matsuoka, K. Kameyama, T. Nakagawa, and N. Okumura
Surgical treatment for non-small cell lung cancer in octogenarians - the usefulness of video-assisted thoracic surgery
Interactive CardioVascular and Thoracic Surgery, August 1, 2009; 9(2): 274 - 277.
[Abstract] [Full Text] [PDF]

Home page
 Ann. Thorac. Surg.Home page
C. W. Seder, K. Hanna, V. Lucia, J. Boura, S. W. Kim, R. J. Welsh, and G. W. Chmielewski
The safe transition from open to thoracoscopic lobectomy: a 5-year experience.
Ann. Thorac. Surg., July 1, 2009; 88(1): 216 - 226.
[Abstract] [Full Text] [PDF]

Home page
 J. Thorac. Cardiovasc. Surg.Home page
M. Shapiro, T. S. Weiser, J. P. Wisnivesky, C. Chin, M. Arustamyan, and S. J. Swanson
Thoracoscopic segmentectomy compares favorably with thoracoscopic lobectomy for patients with small stage I lung cancer.
J. Thorac. Cardiovasc. Surg., June 1, 2009; 137(6): 1388 - 1393.
[Abstract] [Full Text] [PDF]

Home page
 JCOHome page
T. D. Yan, D. Black, P. G. Bannon, and B. C. McCaughan
Systematic Review and Meta-Analysis of Randomized and Nonrandomized Trials on Safety and Efficacy of Video-Assisted Thoracic Surgery Lobectomy for Early-Stage Non-Small-Cell Lung Cancer
J. Clin. Oncol., May 20, 2009; 27(15): 2553 - 2562.
[Abstract] [Full Text] [PDF]

Home page
 ICVTSHome page
T. Karasaki, J. Nakajima, T. Murakawa, T. Fukami, Y. Yoshida, M. Kusakabe, H. Ohtsu, and S. Takamoto
Video-assisted thoracic surgery lobectomy preserves more latissimus dorsi muscle than conventional surgery
Interactive CardioVascular and Thoracic Surgery, March 1, 2009; 8(3): 316 - 320.
[Abstract] [Full Text] [PDF]

Home page
 Ann. Thorac. Surg.Home page
T. A. Lawal, J.-H. Gosemann, J. F. Kuebler, S. Gluer, and B. M. Ure
Thoracoscopy Versus Thoracotomy Improves Midterm Musculoskeletal Status and Cosmesis in Infants and Children
Ann. Thorac. Surg., January 1, 2009; 87(1): 224 - 228.
[Abstract] [Full Text] [PDF]

Home page
 Ann. Thorac. Surg.Home page
R. O. Jones, G. Casali, and W. S. Walker
Does Failed Video-Assisted Lobectomy for Lung Cancer Prejudice Immediate and Long-Term Outcomes?
Ann. Thorac. Surg., July 1, 2008; 86(1): 235 - 239.
[Abstract] [Full Text] [PDF]

Home page
 Ann. Thorac. Surg.Home page
F. Gharagozloo, M. Margolis, and B. Tempesta
Robot-Assisted Thoracoscopic Lobectomy for Early-Stage Lung Cancer
Ann. Thorac. Surg., June 1, 2008; 85(6): 1880 - 1886.
[Abstract] [Full Text] [PDF]

Home page
 Ann. Thorac. Surg.Home page
J. P. Shaw, F. R. Dembitzer, J. P. Wisnivesky, V. R. Litle, T. S. Weiser, J. Yun, C. Chin, and S. J. Swanson
Video-Assisted Thoracoscopic Lobectomy: State of the Art and Future Directions
Ann. Thorac. Surg., February 1, 2008; 85(2): S705 - S709.
[Abstract] [Full Text] [PDF]

Home page
 Ann. Thorac. Surg.Home page
R. M. Flores and N. Alam
Video-Assisted Thoracic Surgery Lobectomy (VATS), Open Thoracotomy, and the Robot for Lung Cancer
Ann. Thorac. Surg., February 1, 2008; 85(2): S710 - S715.
[Abstract] [Full Text] [PDF]

Home page
 Ann. Thorac. Surg.Home page
T. A. D'Amico
Thoracoscopic Segmentectomy: Technical Considerations and Outcomes
Ann. Thorac. Surg., February 1, 2008; 85(2): S716 - S718.
[Full Text] [PDF]

Home page
 Ann. Thorac. Surg.Home page
T. L. Demmy and C. Nwogu
Is Video-Assisted Thoracic Surgery Lobectomy Better? Quality of Life Considerations
Ann. Thorac. Surg., February 1, 2008; 85(2): S719 - S728.
[Abstract] [Full Text] [PDF]

Home page
 ICVTSHome page
M. Salati, A. Brunelli, F. Xiume, M. Refai, V. Sciarra, A. Soccetti, and A. Sabbatini
Uniportal video-assisted thoracic surgery for primary spontaneous pneumothorax: clinical and economic analysis in comparison to the traditional approach
Interactive CardioVascular and Thoracic Surgery, February 1, 2008; 7(1): 63 - 66.
[Abstract] [Full Text] [PDF]

Home page
 Eur. J. Cardiothorac. Surg.Home page
D. Gossot, R. R. Izquierdo, P. Girard, J.-B. Stern, and P. Magdeleinat
Thoracoscopic resection of bulky intrathoracic benign lesions
Eur. J. Cardiothorac. Surg., December 1, 2007; 32(6): 848 - 851.
[Abstract] [Full Text] [PDF]

Home page
 Ann. Thorac. Surg.Home page
K. Ueda, T. Tanaka, M. Jinbo, T. Yagi, T.-S. Li, and K. Hamano
Sutureless Pneumostasis Using Polyglycolic Acid Mesh as Artificial Pleura During Video-Assisted Major Pulmonary Resection
Ann. Thorac. Surg., December 1, 2007; 84(6): 1858 - 1861.
[Abstract] [Full Text] [PDF]

Home page
 JCOHome page
S. J. Swanson, J. E. Herndon II, T. A. D'Amico, T. L. Demmy, R. J. McKenna Jr, M. R. Green, and D. J. Sugarbaker
Video-Assisted Thoracic Surgery Lobectomy: Report of CALGB 39802 A Prospective, Multi-Institution Feasibility Study
J. Clin. Oncol., November 1, 2007; 25(31): 4993 - 4997.
[Abstract] [Full Text] [PDF]

Home page
 Ann. Thorac. Surg.Home page
B. Z. Atkins, D. H. Harpole Jr, J. H. Mangum, E. M. Toloza, T. A. D'Amico, and W. R. Burfeind Jr
Pulmonary Segmentectomy by Thoracotomy or Thoracoscopy: Reduced Hospital Length of Stay With a Minimally-Invasive Approach
Ann. Thorac. Surg., October 1, 2007; 84(4): 1107 - 1113.
[Abstract] [Full Text] [PDF]

Home page
 Ann. Thorac. Surg.Home page
K. Nakanishi
Video-Assisted Thoracic Surgery Lobectomy With Bronchoplasty for Lung Cancer: Initial Experience and Techniques
Ann. Thorac. Surg., July 1, 2007; 84(1): 191 - 195.
[Abstract] [Full Text] [PDF]

Home page
 Ann. Thorac. Surg.Home page
T. C. Mineo, V. Ambrogi, D. Mineo, and E. Pompeo
Transxiphoid Hand-Assisted Videothoracoscopic Surgery
Ann. Thorac. Surg., June 1, 2007; 83(6): 1978 - 1984.
[Abstract] [Full Text] [PDF]

Home page
 Ann. Thorac. Surg.Home page
R. P. Petersen, D. Pham, W. R. Burfeind, S. I. Hanish, E. M. Toloza, D. H. Harpole Jr, and T. A. D'Amico
Thoracoscopic Lobectomy Facilitates the Delivery of Chemotherapy after Resection for Lung Cancer
Ann. Thorac. Surg., April 1, 2007; 83(4): 1245 - 1250.
[Abstract] [Full Text] [PDF]

Home page
 Ann. Thorac. Surg.Home page
M. E. Friscia, J. Zhu, J. W. Kolff, Z. Chen, L. R. Kaiser, C. S. Deutschman, and J. B. Shrager
Cytokine Response is Lower After Lung Volume Reduction Through Bilateral Thoracoscopy Versus Sternotomy
Ann. Thorac. Surg., January 1, 2007; 83(1): 252 - 256.
[Abstract] [Full Text] [PDF]

Home page
 Eur. J. Cardiothorac. Surg.Home page
G. Varela, A. Brunelli, G. Rocco, R. Marasco, M. F. Jimenez, V. Sciarra, J. L. Aranda, and T. Gatani
Predicted versus observed FEV1 in the immediate postoperative period after pulmonary lobectomy.
Eur. J. Cardiothorac. Surg., October 1, 2006; 30(4): 644 - 648.
[Abstract] [Full Text] [PDF]

Home page
 Eur. J. Cardiothorac. Surg.Home page
K. Ueda, M. Sudoh, M. Jinbo, T.-S. Li, K. Suga, and K. Hamano
Physiological rehabilitation after video-assisted lung lobectomy for cancer: a prospective study of measuring daily exercise and oxygenation capacity.
Eur. J. Cardiothorac. Surg., September 1, 2006; 30(3): 533 - 537.
[Abstract] [Full Text] [PDF]

Home page
 Ann. Thorac. Surg.Home page
T. Shiraishi, T. Shirakusa, M. Hiratsuka, S. Yamamoto, and A. Iwasaki
Video-assisted thoracoscopic surgery lobectomy for c-T1N0M0 primary lung cancer: its impact on locoregional control.
Ann. Thorac. Surg., September 1, 2006; 82(3): 1021 - 1026.
[Abstract] [Full Text] [PDF]

Home page
 Ann. Thorac. Surg.Home page
R. P. Petersen, D. Pham, E. M. Toloza, W. R. Burfeind, D. H. Harpole Jr, S. I. Hanish, and T. A. D'Amico
Thoracoscopic lobectomy: a safe and effective strategy for patients receiving induction therapy for non-small cell lung cancer.
Ann. Thorac. Surg., July 1, 2006; 82(1): 214 - 218.
[Abstract] [Full Text] [PDF]

Home page
 Ann. Thorac. Surg.Home page
T. Shiraishi, K. Kawahara, T. Shirakusa, S. Yamamoto, and T. Maekawa
Risk Analysis in Resection of Thoracic Esophageal Cancer in the Era of Endoscopic Surgery
Ann. Thorac. Surg., March 1, 2006; 81(3): 1083 - 1089.
[Abstract] [Full Text] [PDF]

Home page
 ChestHome page
M. E. Froudarakis, M. Klimathianaki, and M. Pougounias
Systemic inflammatory reaction after thoracoscopic talc poudrage.
Chest, February 1, 2006; 129(2): 356 - 361.
[Abstract] [Full Text] [PDF]

Home page
 Br J AnaesthHome page
A. Vogt, D. S. Stieger, C. Theurillat, and M. Curatolo
Single-injection thoracic paravertebral block for postoperative pain treatment after thoracoscopic surgery
Br. J. Anaesth., December 1, 2005; 95(6): 816 - 821.
[Abstract] [Full Text] [PDF]

Home page
 ChestHome page
M. Okada, T. Sakamoto, T. Yuki, T. Mimura, K. Miyoshi, and N. Tsubota
Hybrid Surgical Approach of Video-Assisted Minithoracotomy for Lung Cancer: Significance of Direct Visualization on Quality of Surgery
Chest, October 1, 2005; 128(4): 2696 - 2701.
[Abstract] [Full Text] [PDF]

Home page
 Eur. J. Cardiothorac. Surg.Home page
R. S. Jutley, M. W. Khalil, and G. Rocco
Uniportal vs standard three-port VATS technique for spontaneous pneumothorax: comparison of post-operative pain and residual paraesthesia
Eur. J. Cardiothorac. Surg., July 1, 2005; 28(1): 43 - 46.
[Abstract] [Full Text] [PDF]

Home page
 Eur. J. Cardiothorac. Surg.Home page
M. Jinbo, K. Ueda, Y. Kaneda, M. Sudo, T.-S. Li, and K. Hamano
Video-assisted transcatheter lung perfusion regional chemotherapy
Eur. J. Cardiothorac. Surg., June 1, 2005; 27(6): 1079 - 1082.
[Abstract] [Full Text] [PDF]

Home page
 Ann. Thorac. Surg.Home page
H. Kawai, Y. Tayasu, A. Saitoh, K. Ooyama, Y. Tanaka, Y. Minamiya, and J. Ogawa
Nocturnal Hypoxemia After Lobectomy for Lung Cancer
Ann. Thorac. Surg., April 1, 2005; 79(4): 1162 - 1166.
[Abstract] [Full Text] [PDF]

Home page
 Eur. J. Cardiothorac. Surg.Home page
J. Bodner, H. Wykypiel, G. Wetscher, and T. Schmid
First experiences with the da VinciTM operating robot in thoracic surgery
Eur. J. Cardiothorac. Surg., May 1, 2004; 25(5): 844 - 851.
[Abstract] [Full Text] [PDF]

Home page
 ChestHome page
T. Ohtsuka, H. Nomori, H. Horio, T. Naruke, and K. Suemasu
Is Major Pulmonary Resection by Video-Assisted Thoracic Surgery an Adequate Procedure in Clinical Stage I Lung Cancer?
Chest, May 1, 2004; 125(5): 1742 - 1746.
[Abstract] [Full Text] [PDF]

Home page
 Ann. Thorac. Surg.Home page
K. Ueda, Y. Kaneda, H. Sakano, T. Tanaka, T.-S. Li, and K. Hamano
Obstacles for shortening hospitalization after video-assisted pulmonary resection for lung cancer
Ann. Thorac. Surg., December 1, 2003; 76(6): 1816 - 1820.
[Abstract] [Full Text] [PDF]

Home page
 Ann. Thorac. Surg.Home page
F. Gharagozloo, B. Tempesta, M. Margolis, and E. P. Alexander
Video-assisted thoracic surgery lobectomy for Stage I lung cancer
Ann. Thorac. Surg., October 1, 2003; 76(4): 1009 - 1015.
[Abstract] [Full Text] [PDF]

Home page
 ThoraxHome page
R Booton, M Jones, and N Thatcher
Lung cancer * 7: Management of lung cancer in elderly patients
Thorax, August 1, 2003; 58(8): 711 - 720.
[Full Text] [PDF]

Home page
 Ann. Thorac. Surg.Home page
G. M. Wright, C.P. Clarke, and J. M. Paiva
Hand-assisted thoracoscopic surgery
Ann. Thorac. Surg., May 1, 2003; 75(5): 1665 - 1667.
[Abstract] [Full Text] [PDF]

Home page
 Ann. Thorac. Surg.Home page
R. G. Soto and E. S. Fu
Acute pain management for patients undergoing thoracotomy
Ann. Thorac. Surg., April 1, 2003; 75(4): 1349 - 1357.
[Abstract] [Full Text] [PDF]

Home page
 Eur. J. Cardiothorac. Surg.Home page
W. W.L. Li, R. L.M. Lee, T.W. Lee, C. S.H. Ng, A. D.L. Sihoe, I. Y.P. Wan, A. A. Arifi, and A. P.C. Yim
The impact of thoracic surgical access on early shoulder function: video-assisted thoracic surgery versus posterolateral thoracotomy
Eur. J. Cardiothorac. Surg., March 1, 2003; 23(3): 390 - 396.
[Abstract] [Full Text] [PDF]

Home page
 Eur. J. Cardiothorac. Surg.Home page
W. S. Walker, M. Codispoti, S. Y. Soon, S. Stamenkovic, F. Carnochan, and G. Pugh
Long-term outcomes following VATS lobectomy for non-small cell bronchogenic carcinoma
Eur. J. Cardiothorac. Surg., March 1, 2003; 23(3): 397 - 402.
[Abstract] [Full Text] [PDF]

Home page
 Ann. Thorac. Surg.Home page
A. P.C. Yim
VATS major pulmonary resection revisited--controversies, techniques, and results
Ann. Thorac. Surg., August 1, 2002; 74(2): 615 - 623.
[Abstract] [Full Text] [PDF]

Home page
 Eur. J. Cardiothorac. Surg.Home page
P. Magdeleinat, M. Alifano, A. Petino, J.-P. Le Rochais, E. Dulmet, F. Galateau, P. Icard, and J.-F. Regnard
Solitary fibrous tumors of the pleura: clinical characteristics, surgical treatment and outcome
Eur. J. Cardiothorac. Surg., June 1, 2002; 21(6): 1087 - 1093.
[Abstract] [Full Text] [PDF]

This Article
Right arrow Abstract Freely available
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to Personal Folders
Right arrow Download to citation manager
Right arrow Author home page(s):
Nobuyoshi Shimizu
Right arrow Permission Requests
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Nagahiro, I.
Right arrow Articles by Shimizu, N.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Nagahiro, I.
Right arrow Articles by Shimizu, N.
Related Collections
Right arrow Lung - other

HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
ANN THORAC SURG ASIAN CARDIOVASC THORAC ANN EUR J CARDIOTHORAC SURG
J THORAC CARDIOVASC SURG ICVTS ALL CTSNet JOURNALS