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Ann Thorac Surg 2001;71:397
© 2001 The Society of Thoracic Surgeons

Correspondence

Reversibility of anorexigenic valvulopathy

Tsung O. Cheng, MDa

a Division of Cardiology, George Washington University Medical Center, 2150 Pennsylvania Ave, NW, Washington, DC 20037, USA

To the Editor

I read with interest the case report of cardiac allograft valvulopathy from a donor with antemortem use of fenfluramine-phentermine for the preceding 8 months [1]. Despite removal of the heart from the causative environment, the allograft valvulopathy progressed. This case is contrary to the recent reports that dexfenfluramine-induced valvulopathy may regress after cessation of its use [2, 3]. Does it mean that the mitral valve in a transplanted, and therefore denervated, heart reacts differently from a native valve to cessation of the use of fenfluramine-phentermine?

References

  1. Prasad A., Mehra M., Park M., Scott R., Uber P.A., McFadden P.M. Cardiac allograft valvulopathy: a case of donor-anorexigen-induced valvular disease. Ann Thorac Surg 1999;68:1840-1841.[Abstract/Free Full Text]
  2. Shively B.K., Rolden C.A., Gill F.A., Najarian T., Loar S.B. Prevalence and determinants of valvulopathy in patients treated with dexfenfluramine. Circulation 1999;100:2161-2167.[Abstract/Free Full Text]
  3. Hensrud D.D., Connolly H.M., Grogan M., Miller F.A., Bailey K.R., Jensen M.D. Echocardiographic improvement over time after cessastion of use of fenfluramine and phentermine. Mayo Clin Proc 1999;74:1191-1197.[Medline]

Related Article

Reversibility of anorexigenic valvulopathy: Reply
Mandeep R. Mehra
Ann. Thorac. Surg. 2001 71: 397. [Extract] [Full Text] [PDF]




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