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Ann Thorac Surg 1999;68:1466
© 1999 The Society of Thoracic Surgeons

Supplement: Outcomes ’99: Scientific Abstracts

Assessment of changes in neuropsychological functioning after CABG surgery

G. Dupuis, PhD, E. Kennedy, MSc, R. Lindquist, PhD, F.B. Barton, MS, M.L. Terrin, MD, B.J. Hoogwerf, MD, S.M. Czajkowski, PhD, J.A. Herd, MD, for the POST CABG Biobehavioral Study Investigators

Background: As part of a prospective, multicenter study of the health-related quality of life (HQL) and psychosocial functioning of CABG surgery patients, the POST CABG Biobehavioral Study examined the effects of CABG on neuropsychological functioning.

Methods: Three hundred sixty-five patients (242 men and 123 women) were evaluated before CABG, 549 patients (333 men and 216 women) were evaluated 6 months after surgery, and 296 (197 men and 99 women) were evaluated both before and 6 months after surgery. The neuropsychological battery measured verbal ability (Boston Naming Test, Controlled Word Association: verbal fluency); attention/concentration (WAIS-R digit); logical verbal memory (Weschler Memory Scale A & B); visual memory (Wechsler Visual Reproduction Test) and memory for faces (facial recognition: Benton).

Results: Improvements were found between baseline and 6 months by analysis of mean change in tests of verbal ability (Controlled Word Association, Letter 1, p < .001), attention/concentration (WAIS-R digit, p < .001) and logical memory (Wechsler A & B, p < .001). No scores on any of the neuropsychological measures were observed to decline at the 6 month postoperative follow-up evaluation. Scores for patients tested at 6 months only were similar to those tested at baseline and 6 months, and there were no important differences in the comparison of scores for these two patient groups after adjusting for medical and demographic variables.

Conclusions: In the cohort of patients assessed before and 6 months after CABG surgery, verbal fluency, logical verbal memory, and attention/concentration appear to improve, and no declines in neuropsychological functioning were observed on the battery of tests administered 6 months postoperatively.





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