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Ann Thorac Surg 1999;67:1311
© 1999 The Society of Thoracic Surgeons

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Invited Commentary

^a Cardiothoracic Surgery, Wayne State University School of Medicine and Detroit Medical Center, Harper Professional Building, S-228, 3990 John R. St, Detroit, MI 48201, USA

Invited commentary

Early on, our laboratory was interested in studying the benefits of vascular delay methods for the latissimus dorsi muscle as related to skeletal muscle cardiac assist [1–4]. In three of those early studies [1, 3, 4], the vascular delay techniques used were similar to those reported in the paper by Ali and associates, and we found superior results using vascular delay. Subsequently, using vascular delay techniques that were different from those in the current study, we also found superior performance when prolonged vascular delay methods were used with skeletal muscle ventricles [5]. In a follow-up study, we found that although the performance with prolonged vascular delay in testing the mechanical performance of skeletal muscle ventricles was initially better, over time, the performance of the various groups tested became similar, despite the method of vascular delay [5, 6]. In the current study, they also show superior performance in the vascular delay group, and in the vascular delay group plus electrical stimulation, compared with their control group using a cardiomyoplasty model with cardiac dysfunction. One potential criticism of their study, however, is that the hemodynamic studies were made at one point, and that was only 15 ± 2 days after the cardiomyoplasty procedure. If all animals were followed for an additional 5 or 6 weeks, the hemodynamic performance during latissimus dorsi stimulation may have turned out to be similar for each of the groups. This is an important question that will need to be answered in future studies before one can state that their method of vascular delay is better than the current methods of vascular delay being used.

References

1. Mannion J., Hammond R.L., Stephenson L.W. Hydraulic pouches of canine latissimus dorsi: potential for left ventricular assistance. J Thorac Cardiovasc Surg 1986;91:534-544.[Abstract]
2. Mannion J.D., Velchik M., Acker M.A., Hammond R.L., Alavi A., Stephenson L.W. Transmural blood flow to multi-layered latissimus dorsi skeletal muscle ventricles during circulatory assistance. Trans Amer Soc Artif Intern Organs 1986;32:454-460.
3. Mannion J.D., Acker M.A., Hammond R.L., Faltemeyer W., Duckett S., Stephenson L.W. Power output of skeletal muscle ventricles in circulation: short-term studies. Circulation 1987;76:155-162.[Abstract/Free Full Text]
4. Mannion J.D., Velchik M., Hammond R.L., et al. Effects of collateral blood vessel ligation and electrical conditioning on blood flow in dog latissimus dorsi muscle. J Surg Res 1989;47:332-340.[Medline]
5. Pochettino A., Spanta A.D., Hammond R.L., et al. Skeletal muscle ventricles for total heart replacement. Ann Surg 1990;212:345-352.[Medline]
6. Pochettino A., Lu H., Hammond R.L., et al. Skeletal muscle ventricles in circulation with improved thromboresistance: up to 28 weeks experience. Ann Thorac Surg 1992;53:1025-1032.[Abstract]

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Alert me to new issues of the journal Add to Personal Folders Download to citation manager Author home page(s): Larry W. Stephenson Permission Requests Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Stephenson, L. W. Search for Related Content PubMed Articles by Stephenson, L. W. Related Collections Related Article