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Ann Thorac Surg 1996;62:932-935
© 1996 The Society of Thoracic Surgeons
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Much morbidity and mortality is a direct consequence of the interaction between the patient and operated valve(s), although patient variables (eg, age, degree of coronary arterial disease, follow-up care) may be more responsible for outcomes than an operated valve. However, no set of guidelines can identify all possible patient factors that may affect morbidity and mortality. General agreement regarding the following definitions of terms and suggestions for reporting data do not preclude more detailed analyses or constructive recommendations and investigators are encouraged to identify relevant patient factors in addition to factors related to operated valves.
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| Mortality |
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| Definitions of Morbidity |
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Structural valvular deterioration includes operated valve dysfunction or deterioration exclusive of infection or thrombosis as determined by reoperation, autopsy, or clinical investigation. The term structural deterioration refers to changes intrinsic to the valve, such as wear, fracture, poppet escape, calcification, leaflet tear, stent creep, and suture line disruption of components (eg, leaflets, chordae) of an operated valve.
Nonstructural Dysfunction
Nonstructural dysfunction is any abnormality resulting in stenosis or regurgitation at the operated valve that is not intrinsic to the valve itself.
Nonstructural dysfunction refers to nonstructural problems that result in dysfunction of an operated valve exclusive of thrombosis and infection diagnosed by reoperation, autopsy, or clinical investigation. Examples of nonstructural dysfunction include entrapment by pannus, tissue, or suture; paravalvular leak; inappropriate sizing or positioning; residual leak or obstruction from valve implantation or repair; and clinically important hemolytic anemia.
Sudden or progressive operated valvular dysfunction or deterioration may be structural, nonstructural, or both as determined by reoperation, autopsy or clinical investigation.
Valve Thrombosis
Valve thrombosis is any thrombus, in the absence of infection, attached to or near an operated valve that occludes part of the blood flow path or that interferes with function of the valve.
Valve thrombosis may be documented by operation, autopsy, or clinical investigation.
Embolism
Embolism is any embolic event that occurs in the absence of infection after the immediate perioperative period (when anesthesia-induced unconsciousness is completely reversed).
A neurologic event includes any new, temporary, or permanent focal or global neurologic deficit. A transient ischemic attack is a fully reversible neurologic event that lasts less than 24 hours. A reversible ischemic neurologic deficit is a fully reversible neurologic deficit that lasts more than 24 hours and less than 3 weeks. A stroke or permanent neurologic event lasts more than 3 weeks or causes death. Psychomotor deficits determined by specialized testing are not considered neurologic events related to operated valves. Patients who do not awaken or who awaken after operation with a new stroke are excluded in tabulations of valve related morbidity.
A peripheral embolic event is an operative, autopsy, or clinically documented embolus that produces symptoms from complete or partial obstruction of a peripheral (noncerebral) artery. Patients who awake with a myocardial infarction are excluded. Patients in whom a myocardial infarction develops after the perioperative period are also excluded unless a coronary arterial embolus is shown to be the cause of the infarction by operation, autopsy, or clinical investigation. Emboli proven to consist of nonthrombotic material (eg, atherosclerosis, myxoma) are excluded.
Bleeding Event (Formerly Anticoagulant Hemorrhage)
A bleeding event is any episode of major internal or external bleeding that causes death, hospitalization, or permanent injury (eg, vision loss) or requires transfusion.
The complication "bleeding event" applies to all patients whether or not they are taking anticoagulants or antiplatelet drugs, because bleeding events can occur in patients who are not anticoagulated. Embolic stroke complicated by bleeding is classified as a neurologic event under "embolism" and is not included as a separate bleeding event.
The warfarin anticoagulant status closest to the time that the patient suffers valve thrombosis, embolism, or bleeding event should be reported in international normalized ratio units. Whether or not patients were receiving a platelet inhibitory drug (eg, aspirin, dipyridamole) should also be reported.
Operated Valvular Endocarditis
Operated valvular endocarditis is any infection involving an operated valve.
The diagnosis of operated valvular endocarditis is based on customary clinical criteria including an appropriate combination of positive blood cultures, clinical signs, and/or histologic confirmation of endocarditis at reoperation or autopsy. Morbidity associated with active infection, such as valve thrombosis, thrombotic embolus, bleeding event, or paravalvular leak, is included under this category and is not included in other categories of morbidity.
| Consequences of Morbid Events |
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The reasons for reoperation should be reported and may include reasons other than valve-related morbidity, such as recall, excessive noise, or incidental or prophylactic removal. Enzymatic or catheter-aided therapy of valve-related morbidity is not considered reoperation, but the morbid event that prompted the intervention should be reported.
Valve-Related Mortality
Valve-related mortality is death caused by structural valvular deterioration, nonstructural dysfunction, valve thrombosis, embolism, bleeding event, operated valvular endocarditis, or death related to reoperation of an operated valve. Sudden, unexplained, unexpected deaths of patients with an operated valve are included as valve-related mortality. Deaths caused by heart failure in patients with advanced myocardial disease and satisfactorily functioning cardiac valves are not included. Specific causes of valve-related deaths should be designated and reported.
Sudden Unexpected, Unexplained Death
The cause of these deaths is unknown and the relationship to an operated valve is also unknown. Therefore these deaths should be reported as a separate category of valve-related mortality if the cause cannot be determined by clinical data or autopsy.
Cardiac Death
Cardiac death includes all deaths due to cardiac causes. This category includes valve-related deaths (including sudden unexplained deaths) and nonvalve-related cardiac deaths (eg, congestive heart failure, acute myocardial infarction, documented fatal arrhythmias).
Total Deaths
Total deaths are all deaths due to any cause after a valve operation.
Permanent Valve-Related Impairment
Permanent valve-related impairment is any permanent neurologic or other functional deficit caused by structural valvular deterioration, nonstructural dysfunction, valve thrombosis, thrombotic embolism, bleeding event, operated valvular endocarditis, or reoperation.
| Data Collection |
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Additional Pertinent Material
In addition each report should specify:
| Data Analysis and Reporting |
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As with cardiac surgery, statistical science is a dynamic discipline and the methods used may vary between statisticians. However, in all reports, the conclusions, predictions, and inferences made should be supported by the collected data and appropriate analysis of the data.
Percentages (Not Time-Related)
Some morbid events that occur within a short time frame (such as the interval between operation and 30 days or hospital discharge) may be reported as a simple percentage, ie, the number of events divided by the number of patients (eg, percent operative mortality). Percentages should be presented with confidence intervals [6] and may be compared by
2 analysis or Fisher's exact test [7]. Logistic regression [8] is available for evaluating the simultaneous influence of several risk factors on a dichotomous outcome variable (percentage), and is often used to establish a risk model, ie, a mathematical formula that incorporates such factors.
Time-Related Events
Most valve-related events should be reported in a time-related manner, with operation designated as time zero. Kaplan-Meier [9] or other life-table techniques [10] provide actuarial estimates of morbid events and should be reported with the standard error of the estimate or with appropriate (usually 67% or 95%) confidence limits. The number of patients remaining at risk should be indicated at appropriate intervals, and curves should not be extrapolated beyond time frames containing very few patients. Although comparisons between subsets of patients can be made, actuarial methods are not predictive beyond the time of the last actuarial estimate and cannot be adapted to multivariate analysis. These methods are called nonparametric or distribution-free because they do not assume a particular statistical distribution or model.
The Cox proportional hazard model [11] produces time-dependent analysis of valve-related events and provides a multivariable, stepwise regression method to identify risk factors associated with specific valve-related morbid events during specific time intervals. The Cox method is a semiparametric (model partly specified) approach, which makes no assumption about the shape of the underlying hazard function but identifies risk factors and estimates multipliers of the baseline hazard, which are the relative risks associated with the risk factors. Several methods are available for assessing the assumption of proportional hazards [12]. The results of a multivariable analysis should be accompanied by a list of the variables considered and a tabular presentation of the numeric results.
A fully parametric method (model completely specified) of calculating a hazard function of valve-related morbid events defines the instantaneous risk of an event at any time after operation [1316]. Such methods permit univariate and multivariate analysis, provide predictive information beyond the time of the last event, indicate whether the risk is constant, and provide confidence limits.
Linearized Rates
Some of the above methods have been extended to consider repeated events in the same patient, although the software is not widely available. A simple and widely used approach uses "linearized" rates (events per 100 patient-years or percent per year, calculated as the number of events divided by the total patient-years) to summarize the incidence of multiple events in individual patients. These rates should be considered only approximate unless the hazard function for the complication under study is constant during the entire time interval considered (which is often not true with regard to the early postoperative period), and unless the risk of recurrent events is the same as for initial events (which is often not the case). Linearized rates should be reported with confidence limits, which can be based on the Poisson distribution [17] or on likelihood ratio methods for comparing the means of exponential distributions [11, 18]. Linearized rates can be compared using the likelihood ratio test [15, 16, 19] or a test based on the F statistic [11, 16].
Cumulative Incidence
The hazard function for a given morbid event represents a potential risk; its realization as an actual occurrence is influenced by the competing risks of other events, such as death or explantation, which may terminate the valve's experience before the event being analyzed can occur. The usual actuarial estimates [9, 10] assume that such terminating events are eliminated; it may be useful to determine the actual probability of occurrence, often called the cumulative incidence, which is less than that estimated by the usual actuarial method [4].
| Acknowledgments |
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| Footnotes |
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Address reprint requests to The Society of Thoracic Surgeons, 401 N Michigan Ave, Chicago, IL 60611.
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E. Lansac, I. Di Centa, N. Bonnet, P. Leprince, A. Rama, C. Acar, A. Pavie, and I. Gandjbakhch Aortic prosthetic ring annuloplasty: a useful adjunct to a standardized aortic valve-sparing procedure? Eur. J. Cardiothorac. Surg., April 1, 2006; 29(4): 537 - 544. [Abstract] [Full Text] [PDF] |
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M. Josa, M. Castella, C. Pare, J. L. Bedini, R. Cartana, C. A. Mestres, J. L. Pomar, and J. Mulet Hemolysis in Mechanical Bileaflet Prostheses: Experience With the Bicarbon Valve Ann. Thorac. Surg., April 1, 2006; 81(4): 1291 - 1296. [Abstract] [Full Text] [PDF] |
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F. B. Vanky, E. Hakanson, E. Tamas, and R. Svedjeholm Risk Factors for Postoperative Heart Failure in Patients Operated on for Aortic Stenosis Ann. Thorac. Surg., April 1, 2006; 81(4): 1297 - 1304. [Abstract] [Full Text] [PDF] |
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B.-C. Chang, S.-H. Lim, G. Yi, Y. S. Hong, S. Lee, K.-J. Yoo, M. S. Kang, and B. K. Cho Long-Term Clinical Results of Tricuspid Valve Replacement Ann. Thorac. Surg., April 1, 2006; 81(4): 1317 - 1324. [Abstract] [Full Text] [PDF] |
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V. Chan, W.R. E. Jamieson, A. G. Fleisher, D. Denmark, F. Chan, and E. Germann Valve Replacement Surgery in End-Stage Renal Failure: Mechanical Prostheses Versus Bioprostheses. Ann. Thorac. Surg., March 1, 2006; 81(3): 857 - 862. [Abstract] [Full Text] [PDF] |
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J. P.A. Puvimanasinghe, J. J.M. Takkenberg, M. J.C. Eijkemans, L. A. van Herwerden, W.R. E. Jamieson, G. L. Grunkemeier, J. D. F. Habbema, and A. J.J.C. Bogers Comparison of Carpentier-Edwards pericardial and supraannular bioprostheses in aortic valve replacement Eur. J. Cardiothorac. Surg., March 1, 2006; 29(3): 374 - 379. [Abstract] [Full Text] [PDF] |
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S. O. Shebani, S. McGuirk, M. Baghai, J. Stickley, J. V. De Giovanni, F. A. Bu'Lock, D. J. Barron, and W. J. Brawn Right ventricular outflow tract reconstruction using Contegra(R) valved conduit: natural history and conduit performance under pressure Eur. J. Cardiothorac. Surg., March 1, 2006; 29(3): 397 - 405. [Abstract] [Full Text] [PDF] |
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Aortic root replacement after previous surgical intervention on the aortic valve, aortic root, or ascending aorta. J. Thorac. Cardiovasc. Surg., March 1, 2006; 131(3): 601 - 608. |
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L. Englberger, H. V. Schaff, W.R. E. Jamieson, E. D. Kennard, K. A. Im, R. Holubkov, T. P. Carrel, and for the AVERT Investigators Importance of implant technique on risk of major paravalvular leak (PVL) after St. Jude mechanical heart valve replacement: a report from the Artificial Valve Endocarditis Reduction Trial (AVERT) Eur. J. Cardiothorac. Surg., December 1, 2005; 28(6): 838 - 843. [Abstract] [Full Text] [PDF] |
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X.-M. Zhou, W. Zhuang, J.-G. Hu, J.-M. Li, J.-F. Yu, and L. Jiang Low-Dose Anticoagulation in Chinese Patients with Mechanical Heart Valves Asian Cardiovasc Thorac Ann, December 1, 2005; 13(4): 341 - 344. [Abstract] [Full Text] [PDF] |
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U. Ozyurda, A. R. Akar, O. Uymaz, M. Oguz, M. Ozkan, C. Yildirim, A. Aslan, and R. Tasoz Early clinical experience with the On-X prosthetic heart valve Interactive CardioVascular and Thoracic Surgery, December 1, 2005; 4(6): 588 - 594. [Abstract] [Full Text] [PDF] |
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J. P.A. Puvimanasinghe, J. J.M. Takkenberg, M. J.C. Eijkemans, E. W. Steyerberg, L. A. van Herwerden, G. L. Grunkemeier, J. D. F. Habbema, and A. J.J.C. Bogers Prognosis After Aortic Valve Replacement With the Carpentier-Edwards Pericardial Valve: Use of Microsimulation Ann. Thorac. Surg., September 1, 2005; 80(3): 825 - 831. [Abstract] [Full Text] [PDF] |
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F. Filsoufi, A. C. Anyanwu, S. P. Salzberg, T. Frankel, L. H. Cohn, and D. H. Adams Long-Term Outcomes of Tricuspid Valve Replacement in the Current Era Ann. Thorac. Surg., September 1, 2005; 80(3): 845 - 850. [Abstract] [Full Text] [PDF] |
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K. Kallenbach, M. Karck, D. Pak, R. Salcher, N. Khaladj, R. Leyh, C. Hagl, and A. Haverich Decade of Aortic Valve Sparing Reimplantation: Are We Pushing the Limits Too Far? Circulation, August 30, 2005; 112(9_suppl): I-253 - I-259. [Abstract] [Full Text] [PDF] |
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C. J. Barreiro, N. D. Patel, T. P. Fitton, J. A. Williams, P. N. Bonde, V. Chan, D. E. Alejo, V. L. Gott, and W. A. Baumgartner Aortic Valve Replacement and Concomitant Mitral Valve Regurgitation in the Elderly: Impact on Survival and Functional Outcome Circulation, August 30, 2005; 112(9_suppl): I-443 - I-447. [Abstract] [Full Text] [PDF] |
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Z. A. Halees, M. A. Shahid, A. A. Sanei, A. Sallehuddin, and C. Duran Up to 16 years follow-up of aortic valve reconstruction with pericardium: a stentless readily available cheap valve? Eur. J. Cardiothorac. Surg., August 1, 2005; 28(2): 200 - 205. [Abstract] [Full Text] [PDF] |
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L. S. De Santo, G. Romano, A. D. Corte, F. Tizzano, A. Petraio, C. Amarelli, M. De Feo, G. Dialetto, M. Scardone, and M. Cotrufo Mitral mechanical replacement in young rheumatic women: Analysis of long-term survival, valve-related complications, and pregnancy outcomes over a 3707-patient-year follow-up J. Thorac. Cardiovasc. Surg., July 1, 2005; 130(1): 13 - 19. [Abstract] [Full Text] [PDF] |
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U. K. Chowdhury, A. S. Kumar, B. Airan, D. Mittal, K. G. Subramaniam, R. Prakash, S. Seth, R. Singh, and P. Venugopal Mitral Valve Replacement With and Without Chordal Preservation in a Rheumatic Population: Serial Echocardiographic Assessment of Left Ventricular Size and Function Ann. Thorac. Surg., June 1, 2005; 79(6): 1926 - 1933. [Abstract] [Full Text] [PDF] |
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C. H. Kang, H. Ahn, K. H. Kim, and K.-B. Kim Long-Term Result of 1144 CarboMedics Mechanical Valve Implantations Ann. Thorac. Surg., June 1, 2005; 79(6): 1939 - 1944. [Abstract] [Full Text] [PDF] |
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M. Tamim, T. Bove, Y. Van Belleghem, K. Francois, Y. Taeymans, and G. J Van Nooten Stentless vs. Stented Aortic Valve Replacement: Left Ventricular Mass Regression Asian Cardiovasc Thorac Ann, June 1, 2005; 13(2): 112 - 118. [Abstract] [Full Text] [PDF] |
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M. Tamim, T. Bove, Y. Van Belleghem, F. Caes, K. Francois, and G. J Van Nooten Aortic Valve Replacement with Toronto SPV in Elderly Patients: 10-Year Results Asian Cardiovasc Thorac Ann, June 1, 2005; 13(2): 143 - 148. [Abstract] [Full Text] [PDF] |
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J. I. Aramendi, C.-A. Mestres, J. Martinez-Leon, V. Campos, G. Munoz, and C. Navas Triflusal versus oral anticoagulation for primary prevention of thromboembolism after bioprosthetic valve replacement (trac): prospective, randomized, co-operative trial Eur. J. Cardiothorac. Surg., May 1, 2005; 27(5): 854 - 860. [Abstract] [Full Text] [PDF] |
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G. De Cicco, R. Lorusso, A. Colli, F. Nicolini, C. Fragnito, T. Grimaldi, B. Borrello, A. M. Budillon, T. Gherli, and C. Beghi Aortic Valve Periprosthetic Leakage: Anatomic Observations and Surgical Results Ann. Thorac. Surg., May 1, 2005; 79(5): 1480 - 1485. [Abstract] [Full Text] [PDF] |
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F. Dagenais, P. Cartier, P. Voisine, D. Desaulniers, J. Perron, R. Baillot, G. Raymond, J. Metras, D. Doyle, and P. Mathieu Which biologic valve should we select for the 45- to 65-year-old age group requiring aortic valve replacement? J. Thorac. Cardiovasc. Surg., May 1, 2005; 129(5): 1041 - 1049. [Abstract] [Full Text] [PDF] |
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M. F. O'Brien, M. A.H. Gardner, B. Garlick, H. Jalali, J. A. Gordon, S. L. Whitehouse, W. E. Strugnell, and R. Slaughter CryoLife-O'Brien Stentless Valve: 10-Year Results of 402 Implants Ann. Thorac. Surg., March 1, 2005; 79(3): 757 - 766. [Abstract] [Full Text] [PDF] |
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F. W. Mohr, S. Lehmann, V. Falk, S. Metz, C. Walther, N. Doll, A. Rastan, J. Gummert, and T. Walther Clinical Experience With Stentless Mitral Valve Replacement Ann. Thorac. Surg., March 1, 2005; 79(3): 772 - 775. [Abstract] [Full Text] [PDF] |
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R. Tominaga, K. Kurisu, Y. Ochiai, Y. Tomita, M. Masuda, S. Morita, and H. Yasui A 10-Year Experience With the Carbomedics Cardiac Prosthesis Ann. Thorac. Surg., March 1, 2005; 79(3): 784 - 789. [Abstract] [Full Text] [PDF] |
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D. D. Potter, T. M. Sundt III, K. J. Zehr, J. A. Dearani, R. C. Daly, C. J. Mullany, C. G.A. McGregor, F. J. Puga, H. V. Schaff, and T. A. Orszulak Operative risk of reoperative aortic valve replacement J. Thorac. Cardiovasc. Surg., January 1, 2005; 129(1): 94 - 103. [Abstract] [Full Text] [PDF] |
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H.-Q. T. Ho, V.-P. Nguyen, K.-P. Phan, and N.-V. Pham Mitral Valve Repair with Aortic Valve Replacement in Rheumatic Heart Disease Asian Cardiovasc Thorac Ann, December 1, 2004; 12(4): 341 - 345. [Abstract] [Full Text] [PDF] |
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J P A Puvimanasinghe, J J M Takkenberg, M B Edwards, M J C Eijkemans, E W Steyerberg, L A van Herwerden, K M Taylor, G L Grunkemeier, J D F Habbema, and A J J C Bogers Comparison of outcomes after aortic valve replacement with a mechanical valve or a bioprosthesis using microsimulation Heart, October 1, 2004; 90(10): 1172 - 1178. [Abstract] [Full Text] [PDF] |
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T. Walther, S. Lehmann, V. Falk, S. Metz, N. Doll, A. Rastan, M. Viehweg, M. Richter, J. Gummert, and F. W. Mohr Prospectively Randomized Evaluation of Stented Xenograft Hemodynamic Function in the Aortic Position Circulation, September 14, 2004; 110(11_suppl_1): II-74 - II-78. [Abstract] [Full Text] [PDF] |
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V. DiGregorio, K. J. Zehr, T. A. Orszulak, C. J. Mullany, R. C. Daly, J. A. Dearani, and H. V. Schaff Results of mitral surgery in octogenarians with isolated nonrheumatic mitral regurgitation Ann. Thorac. Surg., September 1, 2004; 78(3): 807 - 813. [Abstract] [Full Text] [PDF] |
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R. G. Masters, M. Haddad, A. L. Pipe, J. P. Veinot, and T. Mesana Clinical outcomes with the Hancock II bioprosthetic valve Ann. Thorac. Surg., September 1, 2004; 78(3): 832 - 836. [Abstract] [Full Text] [PDF] |
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S. A. LeMaire, A. L. Jamison, S. A. Carter, S. Wen, S. Alankar, and J. S. Coselli Deployment of balloon expandable stents during open repair of thoracoabdominal aortic aneurysms: a new strategy for managing renal and mesenteric artery lesions Eur. J. Cardiothorac. Surg., September 1, 2004; 26(3): 599 - 607. [Abstract] [Full Text] [PDF] |
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R. Vink, R. A. Kraaijenhagen, and M. Levi Reply J. Am. Coll. Cardiol., September 1, 2004; 44(5): 1144 - 1145. [Full Text] [PDF] |
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T. Sioris, T. E. David, J. Ivanov, S. Armstrong, and C. M. Feindel Clinical outcomes after separate and composite replacement of the aortic valve and ascending aorta J. Thorac. Cardiovasc. Surg., August 1, 2004; 128(2): 260 - 265. [Abstract] [Full Text] [PDF] |
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G. Gao, Y. Wu, G. L. Grunkemeier, A. P. Furnary, and A. Starr Durability of pericardial versus porcine aortic valves J. Am. Coll. Cardiol., July 21, 2004; 44(2): 384 - 388. [Abstract] [Full Text] [PDF] |
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S. W. Jamieson and M. M. Madani The choice of valve protheses J. Am. Coll. Cardiol., July 21, 2004; 44(2): 389 - 390. [Full Text] [PDF] |
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D. D. Potter, T. M. Sundt III, K. J. Zehr, J. A. Dearani, R. C. Daly, C. J. Mullany, C. G. A. McGregor, F. J. Puga, H. V. Schaff, and T. A. Orszulak Risk of repeat mitral valve replacement for failed mitral valve prostheses Ann. Thorac. Surg., July 1, 2004; 78(1): 67 - 72. [Abstract] [Full Text] [PDF] |
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N. A G Solomon, R. C H Lim, P. Nand, and K. J Graham Tricuspid Valve Replacement: Bioprosthetic or Mechanical Valve? Asian Cardiovasc Thorac Ann, June 1, 2004; 12(2): 143 - 148. [Abstract] [Full Text] [PDF] |
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A. G. Fleisher, R. J. Lafaro, and R. A. Moggio Immediate structural valve deterioration of 27-mm Carpentier-Edwards aortic pericardial bioprosthesis Ann. Thorac. Surg., April 1, 2004; 77(4): 1443 - 1445. [Abstract] [Full Text] [PDF] |
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Y. Wu, R. Gregorio, A. Renzulli, F. Onorati, M. De Feo, G. Grunkemeier, and M. Cotrufo Mechanical heart valves: Are two leaflets better than one? J. Thorac. Cardiovasc. Surg., April 1, 2004; 127(4): 1171 - 1179. [Abstract] [Full Text] [PDF] |
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J.-M. De Smet, B. Rondelet, J.-L. Jansens, M. Antoine, D. De Canniere, and J.-L. Le Clerc Assessment Based on EuroSCORE of Ministernotomy for Aortic Valve Replacement Asian Cardiovasc Thorac Ann, March 1, 2004; 12(1): 53 - 57. [Abstract] [Full Text] [PDF] |
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M. Ruel, A. Kulik, F. D. Rubens, P. Bedard, R. G. Masters, A. L. Pipe, and T. G. Mesana Late incidence and determinants of reoperation in patients with prosthetic heart valves Eur. J. Cardiothorac. Surg., March 1, 2004; 25(3): 364 - 370. [Abstract] [Full Text] [PDF] |
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