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Ann Thorac Surg 2008;86:1320. doi:10.1016/j.athoracsur.2008.07.065
© 2008 The Society of Thoracic Surgeons
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Original Articles: Pediatric Cardiac

Invited Commentary

Patricia A. Thistlethwaite, MD, PhD

Division of Cardiothoracic Surgery, University of California, San Diego, San Diego, CA 92103-8892

(Email: pthistlethwaite@ucsd.edu).

The first 20% of the full text of this article appears below.

Understanding the origins and roles of cardiac progenitor cells is important for determining the pathogenesis of congenital heart diseases. In addition, use of populations of cardiac myocyte progenitors has potential for cell-based repair strategies for acquired adult heart disease.

In the last several years, there has been a surge in the understanding of cardiogenesis at the molecular level. It is now recognized that cardiac muscle cells are derived from the mesoderm, which emerges from the primitive streak during gastrulation. These cells subsequently migrate and form the primitive heart tube, which is shaped by looping and by expansion of the myocardium, ultimately leading to the formation of recognizable cardiac chambers. Several reports suggest that a hierarchal progression of stem cells . . . [Full Text of this Article]


Related Article

Dynamics of Human Myocardial Progenitor Cell Populations in the Neonatal Period
Gabriel Amir, Xiaoyuan Ma, V. Mohan Reddy, Frank L. Hanley, Olaf Reinhartz, Chandra Ramamoorthy, and R. Kirk Riemer
Ann. Thorac. Surg. 2008 86: 1311-1319. [Abstract] [Full Text] [PDF]





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