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Division of Cardiovascular Surgery, Toronto General Hospital, 4N-470, 200 Elizabeth St, Toronto, Ontario, M5G 2C4 Canada
(Email: andrewsycheng88@gmail.com; terry.yau@uhn.on.ca).
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Cell transplantation has undergone intense investigation as a novel therapy for congestive heart failure. There has been concurrent interest in tissue-engineering approaches, largely with the application of cell-seeded biodegradable patches on the epicardial surface of the dilating heart. These constructs have often been associated with enhanced donor cell retention, significant angiogenesis, and reduced infarct expansion, although the relative importance of the donor cells versus the passive mechanical properties of the scaffold has yet to be
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