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Ann Thorac Surg 2008;85:1685. doi:10.1016/j.athoracsur.2008.02.091
© 2008 The Society of Thoracic Surgeons
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Original Articles: Adult Cardiac

Invited Commentary

Niels P. van der Kaaij, MD, Ad J.J.C. Bogers, MD, PhD

Department of Cardiothoracic Surgery, Erasmus MC Rotterdam, Dr Molewaterplein 50, Rotterdam 3015 GE, the Netherlands

(Email: npvdkaaij@gmail.com; a.j.j.c.bogers@erasmusmc.nl).

The first 20% of the full text of this article appears below.

The present study by Cha and colleagues [1] was performed to establish that toll-like receptor 4 (TLR4) exerts its influence on post-ischemic myocardial function through tumor necrosis factor-alpha (TNF-{alpha}) and interleukin (IL)-1β production. The authors state in the introduction that the effect of TLR4 signaling on cardiac function and the contribution of TLR4 to the production of TNF-{alpha} and IL-1β remain to be determined. They also proclaim that the influence of TNF-{alpha} and IL-1β on cardiac function is unclear. Unfortunately, however, scrutinizing the available literature results in useful additional data providing a more sound rationale for this study. . . . [Full Text of this Article]


Related Article

Cytokines Link Toll-Like Receptor 4 Signaling to Cardiac Dysfunction After Global Myocardial Ischemia
John Cha, Zhiping Wang, Lihua Ao, Ning Zou, Charles A. Dinarello, Anirban Banerjee, David A. Fullerton, and Xianzhong Meng
Ann. Thorac. Surg. 2008 85: 1678-1685. [Abstract] [Full Text] [PDF]





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