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This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Alert me to new issues of the journal Add to Personal Folders Download to citation manager Author home page(s): Xu Yu Jin Ravi Pillai Permission Requests Google Scholar Articles by Jin, X. Y. Articles by Pillai, R. PubMed Articles by Jin, X. Y. Articles by Pillai, R. Related Collections Myocardial protection Related Article

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Original Articles: Cardiovascular

Invited Commentary

Department of Cardiothoracic Surgery, John Radcliffe Hospital, Oxford, OX3 9DU United Kingdom

(Email: xy.jin@orh.nhs.uk).

The first 20% of the full text of this article appears below.

To translate compelling science into patient benefits is always a challenging process in modern medicine. The development of effective protection of the hypertrophic hearts during aortic valve replacement (AVR) has been just one of the examples. Although the cardioplegia regime, delivery route, and temperature have reached a general consensus, the clinical benefits of adding "hot shot" at the end of the AVR procedure remain an ongoing debate. The benefits of hot shot to metabolic recovery had been reported during coronary artery bypass surgery [1]. However, the randomized clinical trials reported by Edwards and colleagues [2] and by Falcoz and colleagues [3] in the AVR setting were unable to detect significant differences in cardiac enzyme release early after surgery, when the terminal hot shot was added by antegrade . . . [Full Text of this Article]

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