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Original Articles: Cardiovascular

Invited commentary

Institut de Myologie - INSERM U582, Groupe Hospitalier Pitié-Salpêtrière, 47, Boulevard de l’Hôpital, Paris 75651 Cedex 13, France

(Email: y.fromes@myologie.chups.jussieu.fr).

The first 20% of the full text of this article appears below.

Cardiopulmonary bypass (CPB) has improved a great deal since its early applications; however, a postperfusion syndrome, mainly translated as an acute respiratory distress syndrome, still occurs in some patients. Basically, the inflammatory response to extracorporeal circulation seems to be responsible for impairment of lung function. Blood contact with nonendothelial cell surfaces in the perfusion circuit and the wound activates plasma proteins and cellular blood elements.

All surgery triggers an acute inflammatory response, but persistent exposure of heparinized blood to nonendothelial cell . . . [Full Text of this Article]

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