ATS
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to Personal Folders
Right arrow Download to citation manager
Right arrow Author home page(s):
David J. Chambers
Right arrow Permission Requests
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Chambers, D. J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Chambers, D. J.
Related Collections
Right arrow Myocardial protection
Right arrowRelated Article

Ann Thorac Surg 2007;84:133
© 2007 The Society of Thoracic Surgeons

Original Articles: Cardiovascular

Invited commentary

David J. Chambers, PhD

Cardiac Surgical Research, The Rayne Institute (King’s College London), Guy’s and St. Thomas’ NHS Foundation Trust, St. Thomas’ Hospital, London, SE1 7EH United Kingdom

(Email: david.chambers@kcl.ac.uk).

The first 20% of the full text of this article appears below.

The article by Barillas and colleagues [1] is the latest in an elegant series of studies from this group relating to the effects of ischemia-reperfusion on hypertrophied hearts. The study was conducted on neonatal rabbits that were subjected to aortic banding for 6 weeks to achieve early decompensated hypertrophy, which was shown to reduce tolerance to ischemia-reperfusion. This reduced tolerance is associated with impairment in insulin-induced glucose uptake and seems to be linked to defects in insulin signaling pathway (rather than in glucose transport). The authors hypothesize that glucose synthase kinase-3ß (GSK-3ß; a key intermediate in this pathway) has become activated due to a reciprocal reduction in activity of the . . . [Full Text of this Article]


Related Article

Inhibition of Glycogen Synthase Kinase-3ß Improves Tolerance to Ischemia in Hypertrophied Hearts
Rodrigo Barillas, Ingeborg Friehs, Hung Cao-Danh, Joseph F. Martinez, and Pedro J. del Nido
Ann. Thorac. Surg. 2007 84: 126-133. [Abstract] [Full Text] [PDF]





HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
ANN THORAC SURG ASIAN CARDIOVASC THORAC ANN EUR J CARDIOTHORAC SURG
J THORAC CARDIOVASC SURG ICVTS ALL CTSNet JOURNALS
Copyright © 2007 by The Society of Thoracic Surgeons.