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Ann Thorac Surg 2006;82:2186
© 2006 The Society of Thoracic Surgeons

Original Articles: Cardiovascular

Invited commentary

Y. John Gu, MD, PhD

University Medical Center Groningen, University of Groningen, Hanzeplein 1, Groningen, 9700 RB the Netherlands

(Email: y.j.gu@med.rug.nl).

The first 20% of the full text of this article appears below.

Systemic stress hormone response to cardiopulmonary bypass has been acknowledged for decades since the initial phase of open-heart surgery. Classically this response is reflected by an increase in plasma levels of cortisol, vasopressin, epinephrine, or norepinephrine. In addition, changes in the hypothalamic-pituitary-adrenal axis and the renin-angiotensin-aldosterone system have also been investigated and documented during and after cardiopulmonary bypass. In the present study, Hoda and coworkers [1] introduced leptin, a relatively newly defined molecule known to be released primarily by adipocytes and involved actively in the acute stress response, regulation of the hypothalamic-pituitary-adrenal axis, glucose and insulin . . . [Full Text of this Article]


Related Article

Systemic Stress Hormone Response in Patients Undergoing Open Heart Surgery With or Without Cardiopulmonary Bypass
M. Raschid Hoda, Habib El-Achkar, Edgar Schmitz, Thomas Scheffold, Herbert O. Vetter, and Raffaele De Simone
Ann. Thorac. Surg. 2006 82: 2179-2186. [Abstract] [Full Text] [PDF]





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