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Ann Thorac Surg 2005;80:303
© 2005 The Society of Thoracic Surgeons
a Cardiothoracic Surgery, Brody School of Medicine, East Carolina University, Greenville, NC 27858
b Department of Cardiac Surgery, Austin Hospital, HSB-5, Studley Rd, Heidelberg, Melbourne, Victoria, Australia 3084
(Email: motens@mail.ecu.edu; brian.buxton@austin.org.au).
| The first 20% of the full text of this article appears below. |
Heparin-induced thrombocytopenia (HIT) is a potential life threatening complication of heparin therapy, in particular unfractitionated heparin. Heparin is the mainstay of anticoagulation used for cardiopulmonary bypass thanks to its ease of use, rapid monitoring, short half-life, reversibility, and low cost. As many as 50% of patients have measurable heparin-platelet factor 4 antibody titers develop after cardiac surgery using unfractitionated heparin, but only 1% to 3% have observed HIT (a clinicopathologic diagnosis based on clinical findings, fall in platelet count, and measurable heparin-platelet factor
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Ann. Thorac. Surg. 2005 80: 299-303.
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