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Ann Thorac Surg 2002;73:1769
© 2002 The Society of Thoracic Surgeons

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Original article: cardiovascular

Invited commentary

^a Department of Cardiac Surgery, Children’s Hospital, Harvard Medical School, Boston, MA 02115, USA

e-mail: pedro.delnido@tch.harvard.edu

	Introduction

 
The growth hormone and insulin-like growth factor I (GH-IGF-I) axis plays an important role in cardiac development and plays a trophic role on the heart. There is a high density of growth hormone receptors in cardiomyocytes, and locally produced IGF-I in response to exogenous growth hormone (GH) has been shown to improve contractility and leads to increased synthesis of contractile myofilaments and hypertrophy.

Growth hormone and insulin-like growth factor I axis has also been implicated . . . [Full Text of this Article]

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