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Ann Thorac Surg 2002;73:1235
© 2002 The Society of Thoracic Surgeons

Invited commentary

Robert C. Gorman, MD, Joseph H. Gorman, MD

Department of Surgery, Hospital of the University of Pennsylvania, 3400 Spruce St, Philadelphia, PA 19104, USA

e-mail: gormanr@uphs.upenn.edu

Myocardial stunning is defined as a reversible contractile impairment that is induced by a period of ischemia followed by reperfusion [1]. The mechanism of myocardial stunning remains incompletely elucidated. A better understanding of this phenomenon has important implication for myocardial protection, organ preservation, reperfusion of myocardial infarctions and ventricular remodeling.

Apoptosis is an energy dependent form of cell death that is distinct from necrosis. Initially, it was believed that apoptosis did not occur in terminally differentiated cells such as cardiac myocytes [2]. The discovery . . . [Full Text of this Article]


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Role of apoptosis in myocardial stunning after open heart surgery
Joachim P. Schmitt, Josef Schröder, Heribert Schunkert, Dietrich E. Birnbaum, and Hermann Aebert
Ann. Thorac. Surg. 2002 73: 1229-1235. [Abstract] [Full Text] [PDF]



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J. P. Schmitt and H. Aebert
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Ann. Thorac. Surg., January 1, 2004; 77(1): 382 - 382.
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