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Ann Thorac Surg 2002;73:179
© 2002 The Society of Thoracic Surgeons

Invited commentary

^a Department of Surgery, Course of Interventional Medicine (E1), Osaka University Graduate, School of Medicine, Osaka 565-0871, Japan

e-mail: matsuda@surg1.med.osaka-u.ac.jp

It is a privilege to review and comment on this interesting article. The experimental study presented by Dr Suematsu and coworkers demonstrates the beneficial effects of chronic administration of Nipradilol, a nitric oxide-releasing beta-adrenergic blocker, on myocardial injury following ischemic injury using an isolated rat heart model. The authors have postulated that chronic pretreatment with Nipradilol may attenuate the ischemic myocardial injury by enhancing coronary endothelial nitric oxide (NO) production and reducing lipid-peroxidation, and the results were . . . [Full Text of this Article]

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Long-term treatment with nipradilol, a nitric oxide–releasing ß-adrenergic blocker, enhances postischemic recovery and limits infarct size

Yoshihiro Suematsu, Toshiya Ohtsuka, Hitoshi Horimoto, Katsuhide Maeda, Yasunari Nakai, Shigetoshi Mieno, and Shinichi Takamoto
Ann. Thorac. Surg. 2002 73: 173-179. [Abstract] [Full Text] [PDF]