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Ann Thorac Surg 2001;72:894
© 2001 The Society of Thoracic Surgeons

Invited commentary

Jeffrey M. Piehler, MDa

a Division of Thoracic and Cardiovascular Surgery, University of Kansas Medical Center, 3901 Rainbow Blvd, Suite 1232, Kansas City, KS 66160, USA

e-mail: jpiehler@kumc.edu

Depending upon a variety of host and inoculum factors, pulmonary infection from Aspergillus species forms a spectrum from innocuous colonization of preexisting cavities through rapidly progressive, life-threatening, acute invasive aspergillosis, usually occurring in the setting of immunocompromise. Intermediate between these two extremes is the entity of chronic necrotizing pulmonary aspergillosis (CNPA). CNPA is a slowly progressive, necrotizing pneumonic process which can result in both scar and cavity formation, with cavities containing both fungus and necrotic lung. This type of infection, termed semiinvasive aspergillosis by some authors to distinguish it from the acute form of the disease, usually arises in the setting of at least mild host immunologic compromise, as with diabetes mellitus or steroid use, or of some structural abnormality to the lung parenchyma, as with chronic obstructive lung disease. As one observes the radiographic progression of the disease, the pulmonary infiltrate, usually in the upper lobes, consolidates, frequently cavitates, and is often associated with pleural reaction. . . . [Full Text of this Article]


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Surgical outcome of pulmonary resection in chronic necrotizing pulmonary aspergillosis
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Ann. Thorac. Surg. 2001 72: 889-893. [Abstract] [Full Text] [PDF]





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