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Ann Thorac Surg 2001;72:843-844
© 2001 The Society of Thoracic Surgeons

Invited commentary

Steven E. Anderson, PhDa

a Human Physiology, University of California–Davis, 4147A Tupper Hall, Davis, CA 95616, USA

e-mail: seanderson@ucdavis.edu

This paper is one of numerous recently published which underscores our incomplete understanding of the roles of Na and the Na/H exchanger (NHE1) in myocardial injury induced by ischemia/reperfusion. The hypothesis tested here arises from ample evidence that untreated ischemia leads to increases in cytosolic H, Na, and Ca concentrations with the first two ions linked by NHE1 and the latter two by sarcolemmal Na/Ca exchange. There is also ample evidence that in . . . [Full Text of this Article]


Related Article

Effects of NHE-1 inhibition on cardioprotection and impact on protection by K/Mg cardioplegia
Yoshiya Toyoda, Shaher Khan, Weimin Chen, Robert A. Parker, Sidney Levitsky, and James D. McCully
Ann. Thorac. Surg. 2001 72: 836-843. [Abstract] [Full Text] [PDF]






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