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This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Alert me to new issues of the journal Add to Personal Folders Download to citation manager Author home page(s): Bruce R. Rosengard Permission Requests Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Rosengard, B. R. Search for Related Content PubMed Articles by Rosengard, B. R. Related Collections Transplantation - heart Related Article

Ann Thorac Surg 2001;72:745-746
© 2001 The Society of Thoracic Surgeons

Invited commentary

^a Division of Cardiothoracic Surgery, University of Pennsylvania Health System, 6 Silverstein, 3400 Spruce St, Philadelphia, PA 19104, USA

e-mail: brosengard@mail.med.upenn.edu

Naturally occurring hematopoietic chimerism was first documented by Ray Owen in bovine dizygotic twins, which share a placental circulation [1]. Billingham, Brent, and Medawar found that these non-identical twins would accept reciprocal skin grafts, which was the first demonstration that hematopoietic chimerism was related to transplantation tolerance [2, 3]. In a Nobel Prize winning study, they modeled this experiment of nature by injecting neonatal mice with allogeneic splenocytes and found that chimeras could accept . . . [Full Text of this Article]

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