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Ann Thorac Surg 2001;71:1865
© 2001 The Society of Thoracic Surgeons

Invited commentary

Norman B. Ratliff, MDa

a Department of Anatomic Pathology, The Cleveland Clinic Foundation, 9500 Euclid Ave, Cleveland, OH 44195, USA

e-mail: ratlifn@cesmtp.ccf.org

It has become clear over time, primarily because of the pioneering work of the late Russell Ross and colleagues, that the response to injury, any kind of injury, of the arterial and even venous intima is relatively monomorphic, consisting of the migration of smooth muscle cells into the intima, the proliferation of smooth muscle cells in the intima, and the synthesis and secretion by those same smooth muscle cells of matrix proteins and collagen. This entire process—migration, proliferation, and synthesis—results in intimal thickening, which, by . . . [Full Text of this Article]


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Ann. Thorac. Surg. 2001 71: 1856-1864. [Abstract] [Full Text] [PDF]





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